A5087161723- Reproductive tract infections research
- Pelvic floor disorders treatments
- Cancer-related Molecular Pathways
- Ovarian function and disorders
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Hippo pathway signaling and YAP/TAZ
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Genital Health and Disease
- Urinary Tract Infections Management
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
- Alzheimer's disease research and treatments
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
- Heat shock proteins research
- Sexual function and dysfunction studies
- Reproductive Biology and Fertility
Obstetrics and Gynecology Hospital of Fudan University
2023-2024
Shanghai Jiao Tong University
2014-2024
Academy of Medical Sciences
2024
Academia Sinica
2024
Shanghai Sixth People's Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
International Peace Maternity & Child Health Hospital
2020-2023
Tongren Hospital
2019
Shanghai Ninth People's Hospital
2015-2018
Sentrin/SUMO (small ubiquitin-like modifier)-specific proteases (SENPs) have been implicated in the development of prostate cancer. However, due to low abundance SUMO-modified proteins and high activity SENPs, SUMO substrates affected by SENPs cancer cells are largely unknown. Here, we identified SI2, a novel cell-permeable SENP-specific inhibitor, high-throughput screening. Using SI2 as way inhibiting stably transfected PC3 model, combination with stable isotope labeling amino acids (SILAC)...
Women with polycystic ovarian syndrome (PCOS) often have a history of infertility and poor pregnancy outcome. The character the lower genital tract (LGT) microbiome these patients is still unknown. We collected both vaginal cervical canal swabs from 47 PCOS (diagnosed by Rotterdam Criteria) 50 healthy reproductive-aged controls in this study. Variable regions 3–4 (V3–4) were sequenced analyzed. Operational taxonomic unit (OTU) abundance was noted for all samples. Taxa that discriminated...
The aim of this study was to investigate the oncogenic function and regulatory mechanism stathmin in oral squamous cell carcinoma (OSCC). Two-dimensional electrophoresis liquid chromatography-tandem mass chromatography were applied screen differentiated proteins during carcinogenesis OSCC. Cell Counting Kit-8 (CCK-8) assays, colony formation, migration, flow cytometry, immunofluorescence a xenograft model used detect stathmin. correlation between p53 expression analyzed using...
Despite considerable efficacy of arsenic trioxide (As2O3) in acute promyelocytic leukemia (APL) treatment, other non-APL leukemias, such as chronic myeloid (CML), are less sensitive to As2O3 treatment. However, the underlying mechanism is not well understood. Here we show that relative As2O3-resistant K562 cells have significantly lower ROS levels than As2O3-sensitive NB4 cells. We compared expression several antioxidant enzymes these two cell lines and found peroxiredoxin 1/2/6 catalase...
Abstract We previously found that the lower genital tract (LGT) microbiota of polycystic ovarian syndrome (PCOS) women has altered when compared to healthy reproductive-aged women, however whether this alternation will have an impact on reproductive system function and pregnancy outcomes PCOS patients not yet been identified. Between 2018 2021, we totally enrolled 191 in three independent case-control studies, 209 vaginal cervical swabs, 9 epithelial cells samples were collected from study...
// Jie Ma 1, * , Xiao Tang Wen-wen Sun 1 Ying Liu Yi-ran Tan Hai-long Dong-wang Zhu Min Wang Li-zhen 2 Jiang Li Yao-yao Tu Chen-ping Zhang Zhi-yuan Lai-ping Zhong Department of Oral & Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School Medicine, Shangai, China Pathology, These authors have contributed equally to this work Correspondence to: Zhong, e-mail: zhonglp@hotmail.com Tu, tuyaoyao1117@163.com Keywords: growth differentiation factor 15,...
Our previous phase 3 trial (NCT01542931) failed to demonstrate improved survival when docetaxel, cisplatin and 5‑fluorouracil (TPF) induction chemotherapy was introduced prior surgery postoperative radiotherapy in patients with locally advanced oral squamous cell carcinoma (OSCC). The aim of the present study investigate long‑term predictive value GDF15 expression for potential personalized treatment strategies OSCC. A total 256 stage III/IVA OSCC from our were enrolled study....
Significant lower genital tract (LGT) dysbiosis and an associated rate of clinical pregnancy after in vitro fertilization-frozen embryo transfer (IVF-FET) among polycystic ovary syndrome (PCOS) patients have been previously reported by our group. We aimed to assess whether transvaginal Lactobacillus supplementation can reverse LGT further improve perinatal outcomes PCOS IVF-FET.This is a protocol for multicenter, open-label, randomized controlled trial China. Women diagnosed with who are...
Abstract INTRODUCTION It remains unclear whether the local amyloid‐beta (Aβ) burden in key regions within default mode network (DMN) affects and cognitive functions. METHODS Participants included 1002 individuals from Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F‐florbetapir positron emission tomography resting‐state functional magnetic resonance imaging scanning neuropsychological tests. The correlations between precuneus (PRC) Aβ burden, DMN function, function were...
Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive acute lymphoblastic (ALL) cells. Interestingly, QC inhibits colony formation primary CD34+ progenitor/stem from patients. targets RNA polymerase I, which produces ribosomal (r)RNA, involving protein translation process. Also, treatment prolongs CML-like mice survival K562 tumor growth vivo. conclusion, depletes...