A5026669505- Birth, Development, and Health
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Bariatric Surgery and Outcomes
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Perovskite Materials and Applications
- Reproductive Health and Technologies
- Adipose Tissue and Metabolism
- Organic Light-Emitting Diodes Research
- Air Quality and Health Impacts
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Child and Adolescent Psychosocial and Emotional Development
- Pregnancy and Medication Impact
- Fetal and Pediatric Neurological Disorders
- Sperm and Testicular Function
- Breastfeeding Practices and Influences
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Obstetrics and Gynecology Hospital of Fudan University
2020-2025
Fudan University
2021-2025
Academy of Medical Sciences
2025
Academia Sinica
2025
Zhejiang University
2006-2024
Jiading District Central Hospital
2024
Hunan City University
2024
Zhongda Hospital Southeast University
2015-2024
State Key Laboratory of Biotherapy
2024
On January 20, 2020, a new coronavirus epidemic with human-to-human transmission was officially declared by the Chinese government, which caused significant public panic in China. In light of disease 2019 outbreak, pregnant women may be particularly vulnerable and special need for preventive mental health strategies. Thus far, no reports exist to investigate response outbreak.This study aimed examine impact outbreak on prevalence depressive anxiety symptoms corresponding risk factors among...
To assess whether vaginal secretions and breast milk of women with coronavirus disease 2019 (COVID-19) contain severe acute respiratory syndrome 2 (SARS-CoV-2).Single centre cohort study.Renmin Hospital Wuhan University, Wuhan, Hubei province, China.We studied 13 SARS-CoV-2-infected pregnant diagnosed between 31 January 9 March 2020.We collected clinical data, secretions, stool specimens from during different stages pregnancy neonatal throat anal swabs.We assessed viral presence in...
Background: Mutations in low-density lipoprotein (LDL) receptor ( LDLR ) are one of the main causes familial hypercholesterolemia, which induces atherosclerosis and has a high lifetime risk cardiovascular disease. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system is an effective tool for gene editing to correct mutations thus ameliorate Methods: goal this work was determine whether vivo somatic cell through CRISPR/Cas9 delivered by adeno-associated virus...
Summary Increased fat mass and redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens oestrogens have been observed, the exact mechanism accumulation during remains obscure. In this study, receptor follicle‐stimulating hormone ( FSH ), a gonadotropin that increases sharply persistently with both males females, is functionally expressed human mouse tissues adipocytes. Follicle‐stimulating was found to promote lipid...
Abstract Context Accurate methods for early gestational diabetes mellitus (GDM) (during the first trimester of pregnancy) prediction in Chinese and other populations are lacking. Objectives This work aimed to establish effective models predict GDM. Methods Pregnancy data 73 variables during were extracted from electronic medical record system. Based on a machine learning (ML)-driven feature selection method, 17 selected GDM prediction. To facilitate clinical application, 7 17-variable panel....
As of June 1, 2020, coronavirus disease 2019 (COVID-19) has caused more than 6,000,000 infected persons and 360,000 deaths globally. Previous studies revealed pregnant women with COVID-19 had similar clinical manifestations to nonpregnant women. However, little is known about the outcome neonates born
Reducing cardiovascular disease burden among women remains challenging. Epidemiologic studies have indicated that polycystic ovary syndrome (PCOS), the most common endocrine in of reproductive age, is associated with an increased prevalence and extent coronary artery disease. However, mechanism through which PCOS affects cardiac health unclear.
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that and FSHR play important roles extragonadal tissue. Here, we identified the expression of human mouse pancreatic islet β-cells. Blocking signaling by Fshr knock-out led impaired glucose tolerance owing decreased insulin secretion, while high levels caused insufficient secretion as well. In vitro, orchestrated glucose-stimulated (GSIS) a bell...
Bone morphogenetic protein-15 (BMP-15) has been shown to influence oocyte maturation and quality. However, no relationship established between BMP-15 quality/embryonic development in humans. The aim of this study is investigate level human follicular fluid (FF) its possible role determining quality developmental potential.A total 79 oocytes their corresponding FF from women undergoing ICSI were examined. Individual inseminated subsequently assessed on the basis fertilization, cleavage...
Abstract Background Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and de novo directed by methyltransferases (DNMTs), important for embryo development. Abnormal function of these DNMTs may have serious consequences embryonic Methods To evaluate the possible involvement in human EPL, expression DNMT proteins global were assessed villous or decidua from EPL patients. The...
Though speakers and listeners monitor communication success, they systematically overestimate it. We report an extreme illusion of understanding that exists even without shared language. Native Mandarin Chinese overestimated how well native English-speaking Americans understood what said in Chinese, when were informed the knew no Chinese. These also believed intentions much more than actually did. This impacts theories speech monitoring may be consequential real-life, where miscommunication...
Abstract Background Fertility awareness and menses prediction are important for improving fecundability health management. Previous studies have used physiological parameters, such as basal body temperature (BBT) heart rate (HR), to predict the fertile window menses. However, their accuracy is far from satisfactory. Additionally, few researchers examined irregular menstruators. Thus, we aimed develop menstruation algorithms both regular Methods This was a prospective observational cohort...
Gestational diabetes mellitus (GDM) is an important complication of pregnancy that poses significant threats to women and their offspring. Telomere length shortens as cellular damage increases associated with metabolic diseases. in fetal leucocytes was determined 82 infants GDM (N = 82) 65 normal pregnant 65). Women preeclampsia 45) gestational hypertension 23) were also studied. In the group, telomere significantly shorter than (P 0.028), but there no differences between 0.841) 0.561)....
STUDY QUESTIONDo any mutations in growth differentiation factor 9 (GDF9) have a role diminished ovarian reserve (DOR) young women?
Leukocyte telomere length (LTL) is a predictor of aging and number age-related diseases. We performed genome-wide association studies mean LTL in 2632 individuals,with two-stage replication 3917 individuals from Chinese populations. To further validate our findings, we get the results 696 samples cohort European ancestry. identified two loci associated with that map telomerase reverse transcriptase (TERT; rs2736100, P = 1.93×10−5) on chromosome 5p15.33 near keratin 80 (KRT80; rs17653722,...
BackgroundOn 20th Jan 2020, a new coronavirus epidemic with "human-to-human" transmission was officially announced, which inevitably caused public panic in China. Perinatal depression (PND) is one of the most common mental health problems. The purpose this study to explore impact COVID-19 outbreak on pregnant women.MethodsA total 4124 women during third trimester from 25 hospitals 10 provinces were recruited cross-sectional study, Jan/01 Feb/09, 2020. Among them, 1285 assessed after Jan/20,...
Abstract Background Previous studies have focused on pregnancy outcomes after frozen embryo transfer (FET) performed using different endometrial preparation protocols. Few evaluated the effect of pregnancy-related complications. This study was designed to explore association between protocols and adverse obstetric perinatal complications FET. Methods We retrospectively included all FET cycles ( n = 12,950) in our hospital 2010 2017, categorized them into three groups, natural (NC), hormone...
Introduction Elevated maternal serum lipid concentrations have been related to an adverse intrauterine environment and lead abnormal birth weight. Objective In this study, we aimed explore the association between profiles during early pregnancy weight with stratified pre-pregnancy body mass index (BMI). Methods This retrospective cohort study was based on a large population from two major maternity centers in Shanghai, China. We included 57,516 women singleton live January 2018 October 2020....
Abstract Background Accumulating evidence indicates a key role of Sertoli cell (SC) malfunction in spermatogenesis impairment induced by obesity. Nucleotide-binding oligomerization domain-like receptor with pyrin domain 3 (NLRP3) is expressed SCs, but the NLRP3 pathological process obesity-induced male infertility remains unclear. Methods NLRP3-deficient mice were fed high-fat diet for 24 weeks to establish obesity-related impairment. In another set experiments, lentiviral vector containing...
Few studies have explored the association between a previous caesarean section (CS) and adverse perinatal outcomes in subsequent pregnancy, especially women who underwent non-indicated CS their first delivery. We designed this study to compare of pregnancy spontaneous vaginal delivery (SVD) or This retrospective cohort included singleton deliveries at International Peace Maternity Child Health Hospital from January 2013 December 2016. Data on all were extracted medical records. Multivariate...
Women with polycystic ovarian syndrome (PCOS) often have a history of infertility and poor pregnancy outcome. The character the lower genital tract (LGT) microbiome these patients is still unknown. We collected both vaginal cervical canal swabs from 47 PCOS (diagnosed by Rotterdam Criteria) 50 healthy reproductive-aged controls in this study. Variable regions 3–4 (V3–4) were sequenced analyzed. Operational taxonomic unit (OTU) abundance was noted for all samples. Taxa that discriminated...
Frozen and thawed embryo transfer (FET) is currently widely applied in routine assisted reproductive technology (ART) procedure. It of great necessity to assess the safety FET investigate long-term effect including glucose metabolism on FET-conceived offspring. The mouse model a highly efficient method figure out relationship between process offspring health. In this study, we obtained natural conception (NC), vitro fertilization (IVF), FET. Glucose insulin tolerance test (GTT/ITT) were...