A5102752869- Birth, Development, and Health
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Influenza Virus Research Studies
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Esophageal and GI Pathology
- Medicinal Plants and Bioactive Compounds
- Respiratory viral infections research
- Smoking Behavior and Cessation
- Reproductive System and Pregnancy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Plant Disease Resistance and Genetics
- Genetic Syndromes and Imprinting
- Neuroendocrine Tumor Research Advances
- Viral Infections and Immunology Research
- Sperm and Testicular Function
- Chromosomal and Genetic Variations
- Obstructive Sleep Apnea Research
- Genetic and phenotypic traits in livestock
- Antibiotics Pharmacokinetics and Efficacy
- Ovarian function and disorders
- Genomics and Phylogenetic Studies
- Fatty Acid Research and Health
- Sex and Gender in Healthcare
Women's Hospital, School of Medicine, Zhejiang University
2022-2024
Zhejiang University
2018-2024
Second Affiliated Hospital of Zhejiang University
2024
Ministry of Education of the People's Republic of China
2024
Unimed Medical Institute
2020
Nanjing Children's Hospital
2016
Peking Union Medical College Hospital
2010
Chinese Academy of Medical Sciences & Peking Union Medical College
2010
Iowa State University
2009
Emory University
2009
The Mu transposon system of maize is highly active, with each the approximately 50-100 copies transposing on average once generation. one dozen distinct transposons contain similar 215 bp terminal inverted repeats (TIRs) and generate 9-bp target site duplications (TSDs) upon insertion. Using a novel genome walking strategy that uses these conserved TIRs as primer binding sites, insertion sites were amplified from stocks sequenced via 454 technology. 94% 965,000 reads carried TIRs,...
Reducing cardiovascular disease burden among women remains challenging. Epidemiologic studies have indicated that polycystic ovary syndrome (PCOS), the most common endocrine in of reproductive age, is associated with an increased prevalence and extent coronary artery disease. However, mechanism through which PCOS affects cardiac health unclear.
Objectives: A large meta-analysis indicated a more pronounced association between lower birth weight (BW) and diseases in women but less concern about the causality BW female-related phenotypes diseases. Methods: Mendelian randomization (MR) analysis was used to estimate causal relationship two traits or using summary datasets from genome-wide studies. Exposure instrumental variables are variants that strongly associated with tested four different statistical methods, including inverse...
Objective: A number of epidemiological studies have demonstrated that smoking initiation and alcohol coffee consumption were closely related to women's reproductive health. However, there was still insufficient evidence supporting their direct causality effect. Methods: We utilized two-sample Mendelian randomization (TSMR) analysis with summary datasets from genome-wide association study (GWAS) investigate the causal relationship between initiation, consumption, health-related traits....
While the influence of maternal environmental exposures on offspring long-term health is well recognized, paternal contributions are often overlooked. Recently, a growing body evidence has revealed relationship between obesity and phenotype offspring. This review focused findings effects upon sperm function health, whether these can be reversed in human animal studies. Furthermore, we also provide that epigenetic modifications sperm, including DNA methylation, chromatin histone...
Abstract Background Maternal diabetes mellitus can influence the development of offspring. Gestational (GDM) creates a short-term intrauterine hyperglycaemic environment in offspring, leading to glucose intolerance later life, but long-term effects and specific mechanism involved skeletal muscle dysfunction offspring remain be clarified. Methods Pregnant mice were divided into two groups: The GDM group was intraperitoneally injected with 100 mg/kg streptozotocin on gestational days (GDs) 6.5...
Several studies have documented the high prevalence of obstructive sleep apnea (OSA) among women with polycystic ovary syndrome (PCOS). However, causal relationships between two conditions remain unconfirmed. This study aims to assess OSA and PCOS. We conducted a two-sample Mendelian randomization (MR) analysis utilizing instrumental variables (IVs) derived from large-scale genome-wide association (GWAS) genetically estimate effects PCOS on OSA. To explore impact across different...
Objective To understand the occurrence of vancomycin-associated acute kidney injury (AKI) in patients pediatric intensive care unit (PICU) and explore risk factors. Methods Medical records data children PICU receiving vancomycin treatment, treatment course>48 h, having trough concentration monitoring First Affiliated Hospital Sun Yat-sen University from January 2013 to July 2017 were collected hospital information system retrospectively analyzed. Occurrence AKI was judged based on...
Objective To explore etiological characteristics of hand, foot and mouth disease(HFMD) in Xinjiang 2013. Methods A total 1 287 samples HFMD cases were tested for nucleotide acid enterovirus(EV), human enterovirus 71(EV71), Coxsackievirus A 16( CA16), 109 sample other EV positive 6(CA6) 10(CA10) by real-time reverse transcription polymerase chain reaction (RT-PCR). Six EV71 strains selected to amplify sequence the whole VP1 region using RT-PCR, homology analyzed phylogenetic tree...
Objective To study the agreement and disagreement in definition, standard or method of diagnosis Hirschsprung's disease (HD) Allied disorders Hirschsprung (HAD). Methods Recorded as discussed at workshop International Summit Forum its Diseases, Wuhan, China. Results AchE stain rectal suction biopsy has been recognized gold for preoperative HD. Adequate full-thickness intraoperative was considered to be necessary during surgery IDs, but choice histologic staining not uniform. As...
To assess the relationship of genetically predicted sexual behavior (age at first sex (AFS) and number partners (NSP)) on cardiovascular diseases (CVDs).We performed two-sample Mendelian randomization (MR) with publicly available datasets from UK Biobank FinnGen Study, analyzed genome-wide association results for behaviors twelve types CVDs. The univariable MR method provided a total effect AFS NSP CVDs, showed evidence that early rather than was associated including angina pectoris (AP),...
Abstract Aim Little is known about the molecular pathogenesis of sporadic insulinoma which a type rare endocrine tumors, and there lack reliable biomarkers to differentiate benign from malignant tumors. Thus we analysed CpG island methylator phenotype (CIMP) multiple genes in insulinamas, as well expression p27 relationship between CIMP. Materials Methods Using methylation specific PCR, examined status p16, MLH1, RAR-β, O6-MGMT, THBS1 33 insulinomas 20 paired pancreatic tissues. The was...