A5101909114- Circadian rhythm and melatonin
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- SARS-CoV-2 and COVID-19 Research
- Immune responses and vaccinations
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Ovarian cancer diagnosis and treatment
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
- Adenosine and Purinergic Signaling
- Ovarian function and disorders
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- Climate Change and Health Impacts
- Dietary Effects on Health
- Spaceflight effects on biology
- Cardiac Valve Diseases and Treatments
- Lymphatic System and Diseases
- Cholesterol and Lipid Metabolism
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Shanghai Cancer Institute
2018-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Yangzhou University
2025
Northern Jiangsu People's Hospital
2025
Shaanxi Yulin Energy Group
2024
Shaanxi Yanchang Petroleum (China)
2024
China National Pharmaceutical Group Corporation (China)
2023
A comprehensive understanding of the evolution immune landscape in humans across entire lifespan at single-cell transcriptional and protein levels, during development, maturation senescence is currently lacking. We recruited a total 220 healthy volunteers from Shanghai Pudong Cohort (NCT05206643), spanning 13 age groups 0 to over 90 years, profiled their peripheral cells through RNA-sequencing coupled with single T cell B receptor sequencing, high-throughput mass cytometry, bulk flow...
To determine the roles of vitamin D receptor (VDR) in ischemia/reperfusion-induced myocardial injury and to investigate underlying mechanisms involved.The endogenous VDR expression was detected mouse heart, ischemia/reperfusion (MI/R) upregulated expression. Activation by natural synthetic agonists reduced infarct size improved cardiac function. Mechanistically, activation inhibited endoplasmic reticulum (ER) stress (determined reduction CCAAT/enhancer-binding protein homologous caspase-12...
Abstract Circadian rhythm disruption or decrease in levels of circadian hormones such as melatonin increases ischemic heart disease risk. The nuclear receptors ROR s are pivotally involved regulation and effects mediation. However, the functional roles have never been investigated were therefore subject this study on myocardial ischemia/reperfusion ( MI /R) injury pathogenesis. α γ subtypes detected adult mouse heart, but not was downregulated after /R. To determine pathological consequence...
Abstract Rupture of vulnerable plaques is the main trigger acute cardio‐cerebral vascular events, but mechanisms responsible for transforming a stable atherosclerotic into plaque remain largely unknown. Melatonin, an indoleamine hormone secreted by pineal gland, plays pleiotropic roles in cardiovascular system; however, effect melatonin on rupture and its underlying remains Here, we generated rupture‐prone carotid model induced endogenous renovascular hypertension combined with low shear...
Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift prognosis in AMI remain unclear. This study sought to investigate impact on reperfusion injury, a major determinant clinical outcomes AMI. Study patient data were obtained from database EARLY-MYO-CMR (Early Assessment Myocardial Tissue Characteristics by CMR STEMI) registry, which was prospective, multicenter registry patients ST-segment elevation...
Abstract Aims Adverse cardiovascular events have day/night patterns with peaks in the morning, potentially related to endogenous circadian clock control of platelet activation. Circadian nuclear receptor Rev-erbα is an essential and negative component clock. To date, expression profile biological function platelets never been reported. Methods results Here, we report presence functions human mouse platelets. Both showed a rhythm that positively correlated aggregation. Global knockout...
Reducing cardiovascular disease burden among women remains challenging. Epidemiologic studies have indicated that polycystic ovary syndrome (PCOS), the most common endocrine in of reproductive age, is associated with an increased prevalence and extent coronary artery disease. However, mechanism through which PCOS affects cardiac health unclear.
Abdominal aortic aneurysm (AAA) is a severe disease without effective pharmacological approaches. The nuclear hormone receptor LXRα (liver X α), encoded by the
Abstract Diabetic cardiomyopathy is a major complication that significantly contributes to morbidity and mortality in diabetics with few therapies. Moreover, antidiabetic drugs reported inconsistent or even adverse cardiovascular effects, suggesting it important exploit novel therapeutic targets against diabetic cardiomyopathy. Here, we observed the nuclear melatonin receptor, retinoic acid‐related orphan receptor‐α ( ROR α), was downregulated hearts. By utilizing mouse line α disruption,...
Exercise-induced physiological hypertrophy provides protection against cardiovascular disease, whereas disease-induced pathological leads to heart failure. Emerging evidence suggests pleiotropic roles of melatonin in cardiac disease; however, the effects on vs remain unknown. Using swimming-induced and pressure overload-induced models, we found that treatment significantly improved hypertrophic responses accompanied by alleviated oxidative stress myocardium but did not affect levels. As an...
Objective This study aimed to explore autoantibody clusters and their correlations with clinical features in 644 myasthenia gravis (MG) patients. Methods Medical records of 664 MG patients were reviewed. Five autoantibodies (AChR, MuSK, titin, RyR, LRP4) selected for cluster analysis. The various manifestations compared between clusters. Separate association analyses individual as well among different MGFA subtypes also performed without prior clustering. Results Two separate identified,...
This report represents a caveat publication. Aiming to develop copper-catalyzed synthesis of chromones 2 via an intramolecular Ullmann O-arylation (ortho-halophenyl)propane-1,3-diones 1, Fu and co-workers, their credit, carried out control experiment without copper catalyst. led the discovery that proceeded more efficiently aid transition metal, thus representing normal SNAr process. The reaction was under basic conditions (K2CO3, Na2CO3, K3PO4) in polar aprotic solvents (DMF, DMSO, NMP);...
Liver X receptor (LXR) plays a critical regulatory role in metabolism and inflammation, has been demonstrated to be involved cardiovascular physiology/pathology. In the present study, we investigated effect of GW3965, potent LXR agonist, on diabetic cardiomyopathy (DCM) type 2 db/db mice.Non-diabetic db/+ mice received either vehicle or agonist GW3965 for 12 weeks. Systemic insulin resistance was evaluated by glucose tolerance test homeostasis model assessment resistance. Endpoint cardiac...
Ubiquitin-specific protease 18 (USP18), a USP family member, is involved in antiviral activity and cancer inhibition. Although USP18 expressed heart, the role of heart cardiac diseases remains unknown. Here, we show that expression elevated both human dilated hearts hypertrophic murine models. Cardiomyocyte-specific overexpression mice significantly blunted remodeling as evidenced by mitigated myocardial hypertrophy, fibrosis, ventricular dilation, preserved ejection function, whereas...
Nonalcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis (HS), insulin resistance (IR), and inflammation, poses a high risk of cardiometabolic disorders. Ubiquitin specific protease 4 (USP4), deubiquitinating enzyme, is pivotally involved in regulating multiple inflammatory pathways; however, the role USP4 NAFLD unknown. Here, we report that expression was dramatically down-regulated livers from patients different mouse models induced high-fat diet (HFD) or genetic...
Objective This study aims to explore the mechanism of miR-424-5p/E2F7 axis in hepatocellular carcinoma (HCC) and provide new ideas for targeted therapy HCC. Methods Bioinformatics analysis was used identify target differentially expressed miRNA HCC predict its gene. qRT-PCR employed verify expression miR-424-5p E2F7 mRNA cells. Western blot performed detect effect ectopic on protein E2F7. CCK-8 proliferative activity cells flow cytometry carried out analyzing cell cycle distribution. Dual...
Over 3 billion doses of inactivated vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been administered globally. However, our understanding the immune cell functional transcription and T receptor (TCR)/B (BCR) repertoire dynamics following SARS-CoV-2 vaccination remains poorly understood. Here, we performed single-cell RNA TCR/BCR sequencing on peripheral blood mononuclear cells at four time points after immunization with vaccine BBIBP-CorV. Our analysis...
Background and Purpose Toll‐interacting protein ( T ollip) is an endogenous inhibitor of toll‐like receptors, a superfamily that plays pivotal role in various pathological conditions, including myocardial infarction MI ). However, the exact ollip remains unknown. Experimental Approach models were established knockout KO ) mice, mice with cardiac‐specific overexpression human gene their +/+ non‐transgenic controls respectively. The effects on evaluated by mortality, infarct size cardiac...