A5006722654- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Oceanographic and Atmospheric Processes
- Dietary Effects on Health
- HIV, Drug Use, Sexual Risk
- Microbial Metabolites in Food Biotechnology
- Enzyme Production and Characterization
- Food composition and properties
- Venomous Animal Envenomation and Studies
- Biochemical effects in animals
- Circadian rhythm and melatonin
- melanin and skin pigmentation
- Arctic and Antarctic ice dynamics
- Military Defense Systems Analysis
- Tropical and Extratropical Cyclones Research
- Studies on Chitinases and Chitosanases
- Drug Solubulity and Delivery Systems
- Traditional Chinese Medicine Analysis
- Leech Biology and Applications
- Adolescent Sexual and Reproductive Health
- Protein Hydrolysis and Bioactive Peptides
- Antiplatelet Therapy and Cardiovascular Diseases
- Phytase and its Applications
- Protein Interaction Studies and Fluorescence Analysis
Shanghai Jiao Tong University
2021-2024
Polar Research Institute of China
2023
State Key Laboratory of Oncogene and Related Genes
2022
Renji Hospital
2022
Shanghai Cancer Institute
2022
Yangzhou University
2021
Institute of Medicinal Plant Development
2021
Drexel University
2013-2018
GlaxoSmithKline (United States)
2013-2016
Shaanxi Research Association for Women and Family
2013
Abstract Aims Adverse cardiovascular events have day/night patterns with peaks in the morning, potentially related to endogenous circadian clock control of platelet activation. Circadian nuclear receptor Rev-erbα is an essential and negative component clock. To date, expression profile biological function platelets never been reported. Methods results Here, we report presence functions human mouse platelets. Both showed a rhythm that positively correlated aggregation. Global knockout...
Platelets are versatile anucleate cells involved in thrombosis as well inflammation. Stachydrine (STA), a major bioactive compound extracted from Motherwort, has multiple pharmacological properties. Nevertheless, the significance of STA platelet regulation and whether could ameliorate platelet-mediated thrombo-inflammation still remain elusive.Human platelets were used to assess regulatory effects on activation interactions with neutrophils vitro. FeCl3 injury-induced carotid/mesenteric...
We have reported that the P-gp substrate digoxin required basolateral and apical uptake transport in excess of allowed by passive permeability (as measured presence GF120918) to achieve observed efflux kinetics across MDCK-MDR1-NKI (The Netherlands Cancer Institute) confluent cell monolayers. That is, GF120918 inhibitable was kinetically required. Therefore, IC50 measurements using as a probe this line could be due inhibition P-gp, transport, or both. This kinetic analysis is now extended...
In order to improve the quality of gluten free rice bread (GFRB), pre-gelatinised flour (PGRF) was made and used partially replace natural in production GFRB. The pre-gelatinisation parameters were optimised effects PGRF on GFRB its batter studied. results showed that optimal obtained when 50% total water mixed with 1.0% mixture heated at 80 °C for 2 min. Supplementation significantly improved properties by affecting baking properties, textural colour, crumb grain features. Effects mainly...
From fits of drug transport kinetics across confluent MDCKII-hMDR1-NKI and Caco-2 cell monolayers we estimated the levels efflux active P-glycoprotein (P-gp) in these two lines (companion paper). In present work, compared P-gp number to total level, using liquid chromatography–tandem mass spectrometry, showed that cells is about 10-fold greater than P-gp, whereas values are within twofold. We further visualized microvilli three-dimensional structured illumination super-resolution microscopy...
The best parameters for incorporation into mechanistic physiologically based pharmacokinetic models transporters are system-independent kinetic and active (not total) transporter levels. Previously, we determined the elementary rate constants P-glycoprotein (P-gp)–mediated transport (on- off-rate from membrane to P-gp binding pocket efflux constant apical chamber) using structural mass action model in confluent MDCKII-hMDR1-NKI cell monolayers. In present work, extended analysis Caco-2 cells...
Abstract This study aims at developing and testing a pragmatic expert system for HIV voluntary counseling (VCT-ES) that leverages best practices. The VCT-ES was developed via evolutionary prototyping piloted in 10 (VCT) clinics from Anhui Beijing representative of prefecture county level VCT China. All counselors with the clients to within selected two weeks baseline end were invited participate. Assessment measures included essential procedures (ECPs); clients' satisfaction, knowledge,...
Background: Thrombotic diseases such as myocardial infarction and stroke are closely associated with immune inflammation high prevalent in COVID-19 sepsis. The pathologic mechanism is due to dysregulation hyperactivation of platelet induced thrombotic vascular occlusion. We surprisingly found elevated expression Nrf3 (Nuclear factor erythroid 2-related 3) platelets from patients septic mouse. Considering that the role still remains unknown, we aimed investigate pathological mechanisms...
Abstract The El Niño-Southern Oscillation (ENSO) is a climate phenomenon characterized by the periodic fluctuation of Sea Surface Temperature (SST) anomaly in tropical Pacific Ocean, which has significant impact on global weather and patterns. However, predicting ENSO evolution several seasons advance challenging due to Spring Predictability Barrier (SPB) phenomenon, refers reduced accuracy forecasts during spring. By investigating nonlinear dynamic characteristics systems simulated box...
Earth and Space Science Open Archive This preprint has been submitted to is under consideration at Geophysical Research Letters. ESSOAr a venue for early communication or feedback before peer review. Data may be preliminary.Learn more about preprints preprintOpen AccessYou are viewing the latest version by default [v1]A Nonlinear Cause seasonal Predictability Barrier of SST anomaly in 2 tropical PacificAuthorsDakuanYuiDMengZhouChaoxunHangDe-ZhengSunSee all authors Dakuan YuiD• Submitting...
<p>As part of the ongoing development a data assimilation system for reconstructing Arctic ocean-sea ice state, we incorporated an adjoint sea rheology, which was approximated by free drift assumption due to stability problem, into model coupled model. The sensitivity experiments show that internal stress effect, represented induced remarkable differences in sensitivities and wind central Ocean. In contrast, is mostly marginal zone. reveal including rheology helps extract...