A5032706161- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Medical Image Segmentation Techniques
- Retinal Imaging and Analysis
- Cardiovascular Disease and Adiposity
- Photoacoustic and Ultrasonic Imaging
- Cardiac Structural Anomalies and Repair
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cerebrovascular and Carotid Artery Diseases
- Service-Oriented Architecture and Web Services
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Semantic Web and Ontologies
- Robotics and Sensor-Based Localization
- Atherosclerosis and Cardiovascular Diseases
- Electrical and Bioimpedance Tomography
- Advanced MRI Techniques and Applications
- Flow Measurement and Analysis
- Control and Dynamics of Mobile Robots
- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Signaling Pathways in Disease
- Inflammasome and immune disorders
Sichuan University
2025
West China Hospital of Sichuan University
2025
Shanghai Jiao Tong University
2011-2024
Renji Hospital
2015-2024
XinHua Hospital
2024
Heilongjiang University of Chinese Medicine
2022-2024
UNSW Sydney
2024
The George Institute for Global Health
2024
First People's Hospital of Jingzhou
2021-2024
Wuhan University
2009-2024
Infection with Helicobacter pylori, a Gram-negative, microaerophilic, flagellated bacteria that adheres to human gastric mucosa, is strongly associated ulcers and adenocarcinoma. The mechanisms through which epithelial cells recognize this organism are unclear. In study we evaluated the interactions between Toll-like receptors (TLRs) H. pylori-mediated NF-κB activation induction of chemokine mRNA expression. By reverse transcriptase-PCR determined MKN45 express low but detectable amounts...
Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift prognosis in AMI remain unclear. This study sought to investigate impact on reperfusion injury, a major determinant clinical outcomes AMI. Study patient data were obtained from database EARLY-MYO-CMR (Early Assessment Myocardial Tissue Characteristics by CMR STEMI) registry, which was prospective, multicenter registry patients ST-segment elevation...
Abstract Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable vital life processes such cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key like biogenesis,...
To determine the roles of vitamin D receptor (VDR) in ischemia/reperfusion-induced myocardial injury and to investigate underlying mechanisms involved.The endogenous VDR expression was detected mouse heart, ischemia/reperfusion (MI/R) upregulated expression. Activation by natural synthetic agonists reduced infarct size improved cardiac function. Mechanistically, activation inhibited endoplasmic reticulum (ER) stress (determined reduction CCAAT/enhancer-binding protein homologous caspase-12...
Abstract Rupture of vulnerable plaques is the main trigger acute cardio‐cerebral vascular events, but mechanisms responsible for transforming a stable atherosclerotic into plaque remain largely unknown. Melatonin, an indoleamine hormone secreted by pineal gland, plays pleiotropic roles in cardiovascular system; however, effect melatonin on rupture and its underlying remains Here, we generated rupture‐prone carotid model induced endogenous renovascular hypertension combined with low shear...
Timely primary percutaneous coronary intervention (PPCI) cannot be offered to all patients with ST-segment-elevation myocardial infarction (STEMI). Pharmaco-invasive (PhI) strategy has been proposed as a valuable alternative for eligible STEMI. We conducted randomized study compare the efficacy and safety of PhI half-dose fibrinolytic regimen versus PPCI in STEMI.The EARLY-MYO trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI Acute ST-Segment-Elevation...
Background The pericoronary fat attenuation index (FAI) is assessed using standard coronary computed tomography angiography, and it has emerged as a novel imaging biomarker of inflammation. present study whether increased FAI values on angiography were associated with vulnerable plaque components their intracellular cytokine levels in patients non-ST elevation acute syndrome. Methods Results A total 195 lesions 130 syndrome prospectively included. Lesion-specific FAI, other features...
Background: Metabolic disorder increases the risk of abdominal aortic aneurysm (AAA). NRs (nuclear receptors) have been increasingly recognized as important regulators cell metabolism. However, role in AAA development remains largely unknown. Methods: We analyzed expression profile NR superfamily tissues and identified NR1D1 (NR subfamily 1 group D member 1) most highly upregulated tissues. To examine formation, we used vascular smooth muscle (VSMC)–specific, endothelial cell–specific,...
Educators continue to search for better strategies medical education. Although the unifying theme of reforms was "increasing interest in, attention to, and understanding knowledge base structures", it is difficult achieve all these aspects via a single type instruction. We used related key words in Google Scholar Pubmed. Related results on this topic were selected discussion. Despite range different methods education, students are still required memorize much what they taught, especially...
Abstract Diabetic cardiomyopathy is a major complication that significantly contributes to morbidity and mortality in diabetics with few therapies. Moreover, antidiabetic drugs reported inconsistent or even adverse cardiovascular effects, suggesting it important exploit novel therapeutic targets against diabetic cardiomyopathy. Here, we observed the nuclear melatonin receptor, retinoic acid‐related orphan receptor‐α ( ROR α), was downregulated hearts. By utilizing mouse line α disruption,...
Although robust PCA has been increasingly adopted to extract vessels from X-ray coronary angiography (XCA) images, challenging problems such as inefficient vessel-sparsity modelling, noisy and dynamic background artefacts, high computational cost still remain unsolved. Therefore, we propose a novel unrolling network with sparse feature selection for super-resolution XCA vessel imaging. Being embedded within patch-wise spatiotemporal framework that is built upon pooling layer convolutional...
Positive evidence from clinical trials has fueled growing acceptance of traditional Chinese medicine (TCM) for the treatment cardiac diseases; however, little is known about underlying mechanisms. Here, we investigated nature and mechanisms effects YiXin-Shu (YXS), an antioxidant-enriched TCM formula, on myocardial ischemia/reperfusion (MI/R) injury. YXS pretreatment significantly reduced infarct size improved viable myocardium metabolism function in hypercholesterolemic mice....
Ubiquitin-specific protease 18 (USP18), a USP family member, is involved in antiviral activity and cancer inhibition. Although USP18 expressed heart, the role of heart cardiac diseases remains unknown. Here, we show that expression elevated both human dilated hearts hypertrophic murine models. Cardiomyocyte-specific overexpression mice significantly blunted remodeling as evidenced by mitigated myocardial hypertrophy, fibrosis, ventricular dilation, preserved ejection function, whereas...
Recent studies confirmed that pyroptosis is involved in the progression of pulmonary hypertension (PH), which could promote artery remodeling. Urolithin A (UA), an intestinal flora metabolite ellagitannins (ETs) and ellagic acid (EA), has been proven to possess inhibitory effects on under various pathological conditions. However, its role PH remained undetermined. To investigate potential UA mitigating PH, mice were exposed hypoxia (10% oxygen, 4 weeks) induce with or without treatment....
We sought to develop a new quantitative method evaluate the degree of myocardial perfusion.Currently available methods for assessing perfusion, both TIMI perfusion grading (TMPG) and blush (MBG), are subjective.TIMI Myocardial Perfusion Frame Count (TMPFC), an objective that measures filling clearance contrast in myocardium using cine-angiographic frame-counting, was developed quantify perfusion. 45 normal coronary arteries 15 patients, 137 culprit patients immediately after primary...
Left ventricular thrombus (LVT), a common complication of acute ST-segment elevation myocardial infarction (STEMI), is associated with increased risk systemic embolism and high mortality. Current STEMI guidelines recommend adding anticoagulant therapy to dual antiplatelet (DAPT) if early-formulated LVT were detected, for which vitamin K antagonist (VKA) the standard agent. The role non-VKA oral anticoagulants (NOACs) in this scenario uncertain.The EARLY-MYO-LVT study will be prospective,...