A5102010518- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cell death mechanisms and regulation
- Mechanisms of cancer metastasis
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Long-Term Effects of COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Renin-Angiotensin System Studies
- Sperm and Testicular Function
- ATP Synthase and ATPases Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Enzyme Structure and Function
- Protease and Inhibitor Mechanisms
- Ubiquitin and proteasome pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Respiratory viral infections research
- Tryptophan and brain disorders
- COVID-19 and Mental Health
- Molecular Biology Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Angiogenesis and VEGF in Cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Soochow University
2025
Huazhong Agricultural University
2024
Shanghai First People's Hospital
2016-2023
Shanghai Jiao Tong University
2011-2023
Nanjing University of Chinese Medicine
2017-2022
Renji Hospital
2015-2022
Chinese University of Hong Kong, Shenzhen
2021
University of Chinese Academy of Sciences
2020-2021
University of California, Los Angeles
2021
The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated chelators and can inhibit cancer cell migration. However, the mechanism of how NDRG1 achieves this effect remains unclear. In study, we implemented established newly constructed overexpression knockdown models using DU145, HT29, HCT116 lines to investigate molecular basis which exerts its inhibitory on Using these models, demonstrated that inhibits...
// Fei Zhang 1, * , Xiaoqiang Qi 2, Xiaoxiao Wang 3, Diyang Wei 3 Jiawei Wu 1 Lingling Feng Haiyan Cai Yugang Naiyan Zeng Ting Xu Aiwu Zhou and Ying Zheng Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty Basic Key Laboratory Cell Differentiation Apoptosis The Chinese Ministry Education, Jiao Tong University School Shanghai, China 2 Faculty Nanjing Medical University, Nanjing, Therapeutic Antibody Research Center SEU-Alphamab, Southeast These authors have...
The authors have withdrawn their manuscript whilst they perform additional experiments to test some of conclusions further. Therefore, the do not wish this work be cited as reference for project. If you any questions, please contact corresponding author.
Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on serotonergic system for drug treatment unsatisfactory shows intractable side effects. Multiple evidence suggests that dopamine (DA) dopaminergic signals associated with neuroinflammation are highly involved in pathophysiology of depression as well mechanism antidepressant drugs, which still early stage study worthy investigation.We...
Leonurine is an active alkaloid that extracted from Traditional Chinese Medicine Herba leonuri. Emerging evidence indicates leonurine produces neuroprotective effects in ischemic stroke, Parkinson's disease, and Alzheimer's disease. However, the effect of neuropsychiatric disorders, especially major depression, remains unknown. We used chronic mild stress mouse model to explore antidepressant potential mechanisms. Behavioral tests including sucrose preference test, forced swimming tail...
Although cardiac hypertrophy in hypertension has been well recognized, the molecular mechanisms for development of are still largely unknown. In this study, protein expression profiles left ventricular myocardia spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) at different ages were analyzed using 2-DE combination with MALDI-TOF/TOF MS/MS. The results showed that 20 proteins modulated hypertrophic myocardium. Out these proteins, 13 presented significant changes SHR an early stage...
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is a common and life-threatening infection that imposes up to 30% mortality even when appropriate therapy used. Despite in vitro efficacy determined by minimum inhibitory concentration breakpoints, antibiotics often fail resolve these infections vivo, resulting persistent MRSA bacteremia. Recently, several genetic, epigenetic, proteomic correlates of outcomes have been identified. However, the extent which single...
A novel severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) has been identified as the aetiological agent of SARS. We previously isolated and characterized SARS-CoV SARS-CoV-like viruses from human animals, respectively, suggesting that SARS could be transmitted wild/farmed animals to humans. Comparison viral genomes indicated sequence variation between animal isolates existed mainly in spike (S) gene. hypothesized these variations may underlie a change binding...
FBOX6 ubiquitin ligase complex is involved in the endoplasmic reticulum-associated degradation pathway by mediating ubiquitination of glycoproteins. FBXO6 interacts with chitobiose unfolded N-glycoprotein, pointing glycoproteins toward E2 for ubiquitination. Although glycoprotein-recognizing mechanism well documented, its bona fide interacting are largely unknown. Here we utilized a protein purification approach combined LC-MS to systematically identify FBXO6-interacting Following...
The Z mutation (E342K) of α1-antitrypsin (α1-AT), carried by 4% Northern Europeans, predisposes to early onset emphysema due decreased functional α1-AT in the lung and liver cirrhosis accumulation polymers hepatocytes. However, it remains unclear why causes intracellular polymerization nascent 15% expressed is secreted into circulation as functional, but polymerogenic, monomers. Here, we solve crystal structure Z-monomer have engineered replacements assess conformational role residue Glu-342...
The World Health Organization has recently declared the 2019-novel coronavirus (2019-nCoV) a global public health emergency. Huang et al[1] reported acute kidney injury (AKI) in 7% of 41 patients infected with 2019-nCoV, this value was even higher (up to 31%) among intensive-care patients. Furthermore, Li al[2] that plasma creatinine levels increased 11 59 2019-nCoV infection, suggesting function probably impaired when disease progressed. Guan al[3] level 4.3% severely diseased is highly...
To investigate the prevalence and prognosis of portopulmonary hypertension (PoPH) in liver transplant recipients.Patients with advanced disease who underwent orthotopic transplantation (OLT) were included this retrospective study from January 2012 to June 2015. According 2015 European Society Cardiology (ESC)/European Respiratory (ERS) guidelines for diagnosis pulmonary (PH), patients tricuspid regurgitation velocity (TRV) >3.4 m/s or 2.9 ≤ TRV 3.4 coexisting other echocardiographic PH signs...
Decidual CD4+ T (dCD4 T) cells are crucial for the maternal-fetal immune tolerance required a healthy pregnancy outcome. However, their molecular and functional characteristics not well elucidated. In this study, we performed first analysis of transcriptional alternative splicing (AS) landscapes paired decidual peripheral blood (pCD4 in human early using high throughput mRNA sequencing. Our data showed that dCD4 endowed with unique signature when compared to pCD4 cells: upregulate 1,695...
Significance Up to 30% of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections fail resolve despite appropriate therapy. Such are persistent and life threatening. Because MRSA isolates susceptible antibiotics in vitro, unique interactions among the pathogen, patient, antibiotic occur body that lead outcomes. To study host factors involved persistence, we used state-of-the-art methods explore how genes modified by methylation patients who experience vs. resolving...
Ulcerative colitis (UC) disrupts the colon's protective mucus layer, exposing epithelium to bacteria and triggering inflammation. This barrier, crucial for intestinal health, depends on complex glycosylation, notably sialic acid modifications. However, precise role of acetylation enzyme SIAE (sialic acetylesterase) in UC pathogenesis remains unclear. study investigates glycosylation changes, specifically de-acetylation, progression. Tissue samples were obtained from patients with ulcerative...
We reported recently that moderate hypoxia and hypoxia-mimetic agents could induce growth arrest differentiation of leukemic cells via the mediation hypoxia-inducible factor 1 alpha (HIF-1alpha), but exact molecular mechanisms remain largely unknown. In this study, human acute promonocytic U937 were incubated under 2% O2 or in 50 microM mimetic agent cobalt chloride (CoCl2) normal oxygen for 24 h, their protein expression profiles compared by 2-DE coupled with MALDI-TOF/TOF MS/MS. identified...
Left ventricular thrombus (LVT), a common complication of acute ST-segment elevation myocardial infarction (STEMI), is associated with increased risk systemic embolism and high mortality. Current STEMI guidelines recommend adding anticoagulant therapy to dual antiplatelet (DAPT) if early-formulated LVT were detected, for which vitamin K antagonist (VKA) the standard agent. The role non-VKA oral anticoagulants (NOACs) in this scenario uncertain.The EARLY-MYO-LVT study will be prospective,...
Summary Coronary heart disease (CHD) is one of the most common types organ lesions caused by atherosclerosis, in which CD4+CD25+forkhead box protein 3 (FoxP3+) regulatory T cells (Treg) play an atheroprotective role. However, Treg cell numbers are decreased and their functions impaired atherosclerosis; underlying mechanisms remain unclear. CD31 plays important part response contributes to maintaining tolerance. The immunomodulatory effects also implicated atherosclerosis. In this study, we...