A5085219977- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Helicobacter pylori-related gastroenterology studies
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Liver Diseases and Immunity
- Infant Nutrition and Health
- Ubiquitin and proteasome pathways
- Graphene and Nanomaterials Applications
- Nanocluster Synthesis and Applications
Second Affiliated Hospital of Soochow University
2022-2025
Soochow University
2022-2025
Manipulating intracellular levels of reactive oxygen and nitrogen species (RONS) is great potential for cancer treatment. Inspired by the natural mechanism a radical storm in inflammatory cells via activated regulatable biocatalysis, authors herein report self-powered nanozyme that can enable RONS production tumor cascade reactions. The nanozymes are constructed glucose oxidase (GOx)-templated inverse microemulsion polymerization from acrylamide, arginine-acrylamide, ferrocene-acrylate,...
In ulcerative colitis (UC), the formation of an inflammatory environment is due to combined effects excess production reactive oxygen species (ROS) and nitrogen (RNS), overproduction proinflammatory cytokines, disruption immune system function. There are many kinds traditional drugs for clinical treatment UC, but long-term drug use can cause toxic side resistance also reduce patient compliance other drawbacks. Hence, in light challenges associated with including limitations existing...
Ulcerative colitis (UC) disrupts the colon's protective mucus layer, exposing epithelium to bacteria and triggering inflammation. This barrier, crucial for intestinal health, depends on complex glycosylation, notably sialic acid modifications. However, precise role of acetylation enzyme SIAE (sialic acetylesterase) in UC pathogenesis remains unclear. study investigates glycosylation changes, specifically de-acetylation, progression. Tissue samples were obtained from patients with ulcerative...
Ulcerative colitis (UC) is a chronic inflammatory disease. Intestinal mucosal injury significant factor in UC. Pyroptosis kind of programmed cell death induced by caspases. Proteasome 20S subunit beta 5 (PSMB5) promotes viability. The purpose this study was to determine the impact PSMB5 on intestinal and elucidate underlying processes dextran sulfate sodium- (DSS-) UC mice. Kunming (KM) mice received 3% DSS for days induce We collected clinical symptoms, body weight, colon length,...