A5100622422- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Atherosclerosis and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Cardiac Valve Diseases and Treatments
- Advanced biosensing and bioanalysis techniques
- Cardiac Fibrosis and Remodeling
- Circadian rhythm and melatonin
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- COVID-19 Clinical Research Studies
- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
Shanghai Jiao Tong University
2016-2025
Renji Hospital
2016-2025
Shanghai Cancer Institute
2018-2025
Zhejiang University of Technology
2025
Biomarker Technologies (China)
2025
Ural Federal University
2025
State Key Laboratory of Oncogene and Related Genes
2018-2024
Affiliated Hospital of North Sichuan Medical College
2019-2024
University of Pittsburgh
2024
Yahoo (United Kingdom)
2023
Background:Vitamin C has been demonstrated to kill BRAF mutant colorectal cancer cells selectively.BRAF mutation is the most common genetic alteration in thyroid tumor development and progression; however, antitumor efficacy of vitamin remains be explored. Methods:The effect on cell proliferation apoptosis was assessed by MTT assay flow cytometry.Xenograft transgenic mouse models were used determine its vivo activity C. Molecular biochemical methods elucidate underlying mechanisms anticancer...
Immunotherapy has achieved revolutionary success in clinics, but it remains challenging for treating hepatocellular carcinoma (HCC) characterized by high vascularization. Here, is reported that metal-organic framework-801 (MOF-801) can be employed as a stimulator of interferon genes (STING) through Toll-like receptor 4 (TLR4) not just drug delivery carrier. Notably, cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) and 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) STING agonist...
A comprehensive understanding of the evolution immune landscape in humans across entire lifespan at single-cell transcriptional and protein levels, during development, maturation senescence is currently lacking. We recruited a total 220 healthy volunteers from Shanghai Pudong Cohort (NCT05206643), spanning 13 age groups 0 to over 90 years, profiled their peripheral cells through RNA-sequencing coupled with single T cell B receptor sequencing, high-throughput mass cytometry, bulk flow...
BACKGROUND: The decrease in S-nitrosoglutathione reductase (GSNOR) leads to an elevation of S-nitrosylation, thereby exacerbating the progression cardiomyopathy response hemodynamic stress. However, mechanisms under GSNOR remain unclear. Here, we identify NEDD4 (neuronal precursor cell expressed developmentally downregulated 4) as a novel molecule that plays crucial role pathogenesis pressure overload–induced cardiac hypertrophy, by modulating levels, demonstrating significant therapeutic...
Composite phase-change materials (PCMs) exhibit significant potential for enhancing the thermal performance of building walls. However, previous studies have generally lacked detailed investigations PCM-integrated walls under cold climate conditions. Therefore, in order to evaluate and wall adaptability hollow bricks with composite PCMs climates, a brick model was created by filling PCMs. Then comparative test conducted between PCM-filled conventional non-PCM-filled bricks. The experimental...
AimsEmerging evidence indicates that nuclear receptors play a critical regulatory role in cardiovascular physiology/pathology. Recently, farnesoid-X-receptor (FXR), member of the metabolic receptor superfamily, has been demonstrated to be expressed vascular cells, with important roles However, potential cardiac function FXR remains unclear. We investigated expression and biological FXR.
To determine the roles of vitamin D receptor (VDR) in ischemia/reperfusion-induced myocardial injury and to investigate underlying mechanisms involved.The endogenous VDR expression was detected mouse heart, ischemia/reperfusion (MI/R) upregulated expression. Activation by natural synthetic agonists reduced infarct size improved cardiac function. Mechanistically, activation inhibited endoplasmic reticulum (ER) stress (determined reduction CCAAT/enhancer-binding protein homologous caspase-12...
Abstract Circadian rhythm disruption or decrease in levels of circadian hormones such as melatonin increases ischemic heart disease risk. The nuclear receptors ROR s are pivotally involved regulation and effects mediation. However, the functional roles have never been investigated were therefore subject this study on myocardial ischemia/reperfusion ( MI /R) injury pathogenesis. α γ subtypes detected adult mouse heart, but not was downregulated after /R. To determine pathological consequence...
AimsTo test the hypothesis that near-infrared spectroscopy (NIRS) combined with intravascular ultrasound (IVUS) would provide novel information of human coronary plaque characterization.
Using reversed allosteric communication, we performed MD simulations, MSMs, and mutagenesis experiments, to discover sites. It reproduced the known site for MDL-801 on Sirt6 uncovered a novel cryptic Pocket X.
Abstract Aims Facial features were associated with increased risk of coronary artery disease (CAD). We developed and validated a deep learning algorithm for detecting CAD based on facial photos. Methods results conducted multicentre cross-sectional study patients undergoing angiography or computed tomography at nine Chinese sites to train validate convolutional neural network the detection (at least one ≥50% stenosis) from patient Between July 2017 March 2019, 5796 eight consecutively...
Abstract Rupture of vulnerable plaques is the main trigger acute cardio‐cerebral vascular events, but mechanisms responsible for transforming a stable atherosclerotic into plaque remain largely unknown. Melatonin, an indoleamine hormone secreted by pineal gland, plays pleiotropic roles in cardiovascular system; however, effect melatonin on rupture and its underlying remains Here, we generated rupture‐prone carotid model induced endogenous renovascular hypertension combined with low shear...
Atherosclerosis is a chronic disease comprising intima malfunction and arterial inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory response in atherosclerosis exert subsequent atheroprotective effects. Our previous study also the role of inhibition inflammation by atorvastatin vitro. Therefore, present study, we aimed to determine whether upregulate cytokines secretion, lipid accumulation, improve vulnerable plaque stability, both vitro vivo. First,...
Timely primary percutaneous coronary intervention (PPCI) cannot be offered to all patients with ST-segment-elevation myocardial infarction (STEMI). Pharmaco-invasive (PhI) strategy has been proposed as a valuable alternative for eligible STEMI. We conducted randomized study compare the efficacy and safety of PhI half-dose fibrinolytic regimen versus PPCI in STEMI.The EARLY-MYO trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI Acute ST-Segment-Elevation...
Background and Aims Protein S‐sulfhydration mediated by H 2 S has been shown to play important roles in several diseases. However, its precise role liver disease the related mechanism remain unclear. Approach Results We showed that streptozotocin (STZ)–treated high‐fat diet (HFD)–treated low‐density lipoprotein receptor–negative (LDLr −/− ) mice, donor GYY4137 ameliorated injury, decreased serum alanine aminotransferase (ALT) aspartate (AST) levels, mitigated lipid deposition, reduced...
Background: Emerging studies have described and analyzed epidemiological, clinical, laboratory, radiological features of COVID-19 patients. Yet, scarce information is available regarding the association lipid profile disease severity mortality. Methods: We conducted a prospective observational cohort study to investigate in patients with COVID-19. From 9 February 4 April 2020, total 99 (31 critically ill 20 severely ill) confirmed were included study. Dynamic alterations profiles recorded...