A5079555879- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- High-Energy Particle Collisions Research
- DNA and Nucleic Acid Chemistry
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Graphene and Nanomaterials Applications
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Quantum Dots Synthesis And Properties
- Flame retardant materials and properties
- Modular Robots and Swarm Intelligence
- Electrospun Nanofibers in Biomedical Applications
- Sphingolipid Metabolism and Signaling
- Wound Healing and Treatments
- Advanced Nanomaterials in Catalysis
- 3D Printing in Biomedical Research
- Animal Nutrition and Physiology
- Dendrimers and Hyperbranched Polymers
- Photopolymerization techniques and applications
State Key Laboratory of Oncogene and Related Genes
2015-2025
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Shanghai Cancer Institute
2016-2025
Jiading District Central Hospital
2025
Wuhan University of Technology
2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Huazhong University of Science and Technology
2022-2024
Sanya University
2024
Hainan University
2024
Immunotherapy has achieved revolutionary success in clinics, but it remains challenging for treating hepatocellular carcinoma (HCC) characterized by high vascularization. Here, is reported that metal-organic framework-801 (MOF-801) can be employed as a stimulator of interferon genes (STING) through Toll-like receptor 4 (TLR4) not just drug delivery carrier. Notably, cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) and 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) STING agonist...
Photodynamic therapy (PDT) depends on the light-irradiated exciting of photosensitizer (PS) to generate reactive oxygen species (ROS), which faces challenges and limitations in hypoxia antioxidant response cancer cells, limited tissue-penetration light. Herein, a multifunctional DNA/upconversion nanoparticles (UCNPs) complex is developed enables controlled co-delivery CRISPR-Cas9, hemin, protoporphyrin (PP) for synergistic PDT. An ultralong single-stranded DNA (ssDNA) prepared via rolling...
For practical biomedical applications, the stabilization of nanoscale metal–organic frameworks (NMOFs) in presence phosphate is prime importance but remains a significant challenge because inevitable and strong driving force between metal clusters species to form metal-phosphate physiological environments. Through shielding Zr-NMOFs within continuous phospholipid bilayers (PBLs), herein, we figured out unique way protect vulnerable coordination bonds their from attack phosphate. To exemplify...
Ancient biomass is the main source for petrochemicals including plastics, which are inherently difficult to be degraded, increasingly polluting earth's ecosystem our oceans. To reduce consumption by substituting or even replacing most of with degradable and renewable materials inevitable urgent a sustainable future. We report here unique strategy directly convert DNA, at large scale low cost, diverse gels, membranes, plastics without breaking down DNA first into building blocks polymer...
Abstract The trans‐cleavage property of CRISPR‐Cas12a system makes it an excellent tool for disease diagnosis. Nevertheless, most methods based on CRISPR‐Cas still require pre‐amplification the target to achieve desired detection sensitivity. Here we generate Framework‐Hotspot reporters (FHRs) with different local densities investigate their effect activity Cas12a. We find that cleavage efficiency increases and rate accelerates increasing reporter density. further construct a modular sensing...
Point-of-care testing (POCT) can be the method of choice for detecting infectious pathogens; these pathogens are responsible not only diseases such as COVID-19, but also certain types cancers. For example, infections by human papillomavirus (HPV) or Helicobacter pylori (H. pylori) main cause cervical and stomach cancers, respectively. COVID-19 many cancers treatable with early diagnoses using POCT. A variety nucleic acid have been developed use in resource-limited environments. However,...
Abstract Immunotherapy shows immense promise for improving cancer treatment. Combining immunotherapy with radiotherapy provides a conspicuous advantage due to its enhanced abscopal effect. However, established immune tolerance mechanisms in the tumor microenvironment can hamper generation of sufficient Herein, type DNA nanocluster (DNAnc) that is self‐assembled by CpG‐ODNs‐loaded Y‐shaped double‐stranded vector based on unique complementary base‐pairing rules designed. The structure DNAnc...
Gastric cancer relevant<sc>d</sc>-amino acids were non-invasively detected with luminescent DNA/silver nanoclusters.
An emergent locomotion behavior was programmed from a mesoscale DNA material powered by artificial metabolism.
Abstract Messenger RNA (mRNA) transfection is the prerequisite for application of mRNA‐based therapeutics. In hard‐to‐transfect cells, such as macrophages, effective mRNA remains a long‐standing challenge. Herein, smart DNA‐based nanosystem reported containing ribosome biogenesis‐promoting siRNA, realizing efficient in macrophages. Four monomers are copolymerized to form nanoframework (NF), including N ‐isopropylacrylamide (NIPAM) skeleton and acrydite‐DNA initiator trigger cascade assembly...
Abstract The inflammatory damage caused by thrombus formation and dissolution can increase the risk of thrombotic complications on top cell death organ dysfunction itself. Therefore, a rapid precise thrombolytic therapy strategy is in urgent need to effectively dissolve resist oxidation simultaneously. In this study, Ce‐UiO‐66, cerium‐based metal–organic framework (Ce‐MOF) with reactive oxygen species (ROS) scavenging properties, encapsulated low‐immunogenic mesenchymal stem membrane...
Glioma stem cells (GSCs) are a special subpopulation of glioma that key to the sensitivity tumors treatments and possibility tumor recurrence. Identifying new strategies inhibit growth GSCs therefore important for developing novel therapies glioblastoma multiforme (GBM). In this study, CD133+ human were isolated cultured. Magnetic nanoparticles used mediate expression siRNAs targeting HOTAIR (si-HOTAIR) sequence in gliomas. Effect downregulation on proliferation, invasion vivo tumorigenicity...
Abstract Hepatic carcinoma (HCC) is a lethal disease associated with high morbidity and poor prognosis. Recently years, gene therapies have offered novel modalities to improve the prognosis of HCC patients. MicroRNA-99a (miR-99a) frequently down-regulated in HCC, where it acts as tumor suppressor. Therefore, we constructed monomethoxy (polyethylene glycol)-poly(D,L-lactide- co -glycolide)-poly(L-lysine)-lactobionic acid- anti-vascular endothelial growth factor antibody...
Abstract The combined treatment with nanoparticles and autophagy inhibitors, such as chloroquine (CQ) hydroxychloroquine (HCQ), is extensively explored for cancer therapy. However, the toxicity of inhibitors their unselective tumoricidal have seriously hindered application treatment. In this study, a carboxy‐functional iron oxide nanoparticle (Fe 2 O 3 @DMSA) designed identified to significantly exert an antitumor effect without adding CQ or HCQ. Further investigation indicates that...
Abstract Diagnostic testing of biological macromolecules is great significance for early warning disease and cancer. Nevertheless, restricted by limited surface area large steric hindrance, sensitive detection with interface‐based sensing method remains challenging. Here, a “biphasic replacement” electrochemical aptamer‐based (BRE‐AB) strategy which placed capture reaction the biomacromolecule in homogeneous solution phase replaced small diameter single‐stranded DNA to attach interface...
Directly delivering therapeutic proteins to their intracellular targets remains a great challenge. Here, we apply CD8+ T cells form pores on the tumor cells' plasma membranes, enabling perfusion of ribonuclease A (RNase A) and granzyme B into cells, therefore effectively inducing apoptosis pyroptosis by activating caspase 3 gasdermin E pathways potentiate cell-mediated immunotherapy. Then, RNase A, programmed cell death ligand 1 antibody, photothermal agent were further loaded an injectable...
Abstract CRISPR‐Cas9 has demonstrated potential in inhibiting tumor growth by downregulating target gene expression, and the efficiency is expected to be enhanced with other nucleic acid drugs. Herein, a dual‐enzyme–responsive DNA‐based nanoframework (NF) that enables controlled co‐delivery of Cas9 ribonucleoprotein (RNP) antisense oligodeoxynucleotide (ASO) for synergistic therapy reported. NF synthesized acrylamide DNA (acDNA) as cross‐linker loading site. A ternary complex containing...