A5013921703- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- RNA regulation and disease
- Head and Neck Cancer Studies
- Ear Surgery and Otitis Media
- Corneal surgery and disorders
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- Systemic Sclerosis and Related Diseases
- Circular RNAs in diseases
- Otitis Media and Relapsing Polychondritis
- Advanced biosensing and bioanalysis techniques
- Plant Physiology and Cultivation Studies
- Postharvest Quality and Shelf Life Management
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Ophthalmology and Visual Impairment Studies
- Genomics and Rare Diseases
- COVID-19 and Mental Health
- Retinal Diseases and Treatments
- Cancer Cells and Metastasis
Willamette University
2019-2025
Oregon State University
2019-2025
Peking University Shenzhen Hospital
2015-2024
Capital Medical University
2020-2024
Beijing Chao-Yang Hospital
2022-2024
Binzhou University
2023-2024
Binzhou Medical University
2023-2024
Renji Hospital
2014-2023
Shanghai Jiao Tong University
2020-2023
Institute of Process Engineering
2022-2023
Abstract The trans‐cleavage property of CRISPR‐Cas12a system makes it an excellent tool for disease diagnosis. Nevertheless, most methods based on CRISPR‐Cas still require pre‐amplification the target to achieve desired detection sensitivity. Here we generate Framework‐Hotspot reporters (FHRs) with different local densities investigate their effect activity Cas12a. We find that cleavage efficiency increases and rate accelerates increasing reporter density. further construct a modular sensing...
Nowadays, social media tools such as short message service, Twitter, video, and web-based systems are more used in clinical follow-up, making follow-up much time- cost-effective than ever before. However, the most popular China, little is known about utility of smartphone WeChat application follow-up. In this study, we aimed to investigate feasibility superiority follow-up.A total 108 patients diagnosed with head neck tumor were randomized (WFU) group or telephone (TFU) for 6-month The...
The authors have withdrawn their manuscript whilst they perform additional experiments to test some of conclusions further. Therefore, the do not wish this work be cited as reference for project. If you any questions, please contact corresponding author.
MicroRNAs (miRNAs) are small noncoding RNA molecules which involved in tumorigenesis and development. To investigate their role primary laryngeal squamous cell carcinoma (LSCC), miRNA GeneChips were used to screen the differentially expressed miRNA, then validated by real-time quantitative PCR LSCC samples, we found that miR-375 was frequently downregulated tissues. The tumor-suppressive effect of determined vitro assays; through gain-of-function studies demonstrated can inhibit (SNU-48...
Dry eye disease (DED), a complex ocular surface with high prevalence rate, is associated corneal injury, excess oxidative stress and inflammation. Current therapeutic strategies, including artificial tears anti-inflammatory agents, are unable to address all the deleterious factors or achieve clinical cure due their temporary side effects. Here, we prepared multiple-functional eyedrop based on deposition of gold nanoparticles (AuNPs) reduced by ascorbic acid (AA) onto exosomal phospholipid...
Contamination of fresh blueberries via contact with an equipment surface is important food hygiene/safety issue. In this study, four and six over-the-row blueberry machine harvesters in Georgia or Oregon were each sampled twice on two different harvest days the 2022 season. Nine sites top loaders (n = 8) seven bottom 2) before after cleaning/sanitation. Populations total aerobes (TA), yeasts molds (YM), coliforms (TC), presence fecal (FC) enterococci (EC) collected samples determined. Data...
Previous studies have found that miR-375 and miR-205 were significantly dysregulated in laryngeal squamous cell carcinoma, which contributed to the invasion migration of LSCC. However, mechanisms regulating LSCC remain unknown. qRT-PCR was performed 40 pairs tissue samples investigate expression paracarcinoma tissues. To whether or not regulated synergistically via AKT-mediated epithelial-mesenchymal transition, mimic inhibitor transfected into SNU899 cells cells, respectively, with without...
Purpose: To explore the feasibility of corneal morphological and biomechanical parameters for keratoconus forme fruste diagnosis.Methods: This case-control study included a total 517 eyes from 408 patients (KC group), 83 (FFKC 158 with normal corneas (NL group). All subjects underwent routine ophthalmologic examinations. Pentacam Corneal Visualization Scheimpflug Technology (Corvis ST) were used to obtain parameters. Differences between groups compared using receiver operating characteristic...
This study sought to investigate the protective effect of an alternative medicine, Shufeng Jiedu Capsule, in acute lung injury and inflammation signaling pathways related that action. Hematoxylin eosin (HE) staining was used observe pathological changes rat tissue, arterial blood subjected gas analysis lactic acid levels were determined, immunofluorescent for interleukin-1β (IL-1β) performed, enzyme linked immunosorbent assay (ELISA) detect biomarkers nuclear factor-κB (NF-κB) pathway...
Abstract This study aimed to compare the accuracy of CT and MRI in determining invasion thyroid cartilage by T staging laryngeal carcinoma with anterior vocal commissure (AVC) involvement. A total 26 cases carcinomas AVC involvement from May 2012 January 2014 underwent enhanced scan, out whom 6 patients also diffusion-weighted magnetic resonance imaging(DWI). were evaluated. All surgical specimens serial section reviewed two senior pathologists independently. When compared pathologic...
Accumulating evidence indicates that lncRNAs can interact with miRNAs to regulate target mRNAs through competitive interactions. However, this mechanism remains largely unexplored in laryngeal squamous cell carcinoma (LSCC). In study, transcriptome-wide RNA sequencing was performed on 3 pairs of LSCC tissues and adjacent normal investigate the expression profiles lncRNAs, mRNAs, differential 171 36 1709 detected. Seven eight three were identified be dysregulated patients' by using qRT-PCR....
Background: We described the prevalence of anxiety and depression related to COVID-19 pandemic among different types population examined their potential risk factors. Methods: A cross-sectional survey was conducted collect demographic characteristics, exposure histories, many other concerns about COVID-19. The Zung's self-rating scale (SAS) (SDS), followed by a four-step multiple logistic regression analysis performed identify factors associated with mental health outcomes. Results: Out...
Peanut (Arachis hypogaea L.) is an important oilseed crop worldwide. However, soil salinization becomes one of the main limiting factors peanut production. Therefore, developing salt-tolerant varieties and understanding molecular mechanisms salt tolerance to protect yield in saline areas. In this study, we selected four with contrasting response challenges T1 T2 being S1 S2 susceptible. High-throughput RNA sequencing resulted more than 314.63 Gb clean data from 48 samples. We identified...
To review the prevalence and clinical characteristics of vestibular schwannoma (VS) in patients with sudden sensorineural hearing loss (SSNHL) southern China. This study examined medical records MRI findings all 1249 diagnosed SSNHL between May 2009 April 2019 Division Otolaryngology at Peking University Shenzhen Hospital. Among SSNHL, VS was found 14 (1.12%). patients, 11 (78.6%) complained tinnitus 3 (21.4%) dizziness as accompanying symptoms. There one patient right ear who had an...
The mechanism of nasopharyngeal carcinoma (NPC) remains unclear. present study investigated the abnormal expression long non-coding (lnc)RNAs in NPC tissues and one cell line to identify involvement lncRNAs tumorigenesis NPC. Using a quantitative reverse transcription polymerase chain reaction (RT‑qPCR), lncRNA C22orf32-1 an was verified. effects C22orf32‑1 on cells were with proliferation assay, scratch Transwell assay apoptosis assay. levels upregulated. promoted proliferation, migration...
Abstract Genetic causes of hearing loss are highly heterogeneous and often ethnically specific. In recent years, a variety next‐generation sequencing (NGS) panels have been developed to target deafness‐causative genes. Whole‐exome (WES), on the other hand, was rarely used for genetic testing deafness. this study, we performed WES in 38 sporadic Chinese Han deaf patients who pre‐excluded mutations common deafness genes GJB2 , SLC26A4 MT‐RNR1 . Non‐synonymous variants filtered based their...
Abstract The trans‐cleavage property of CRISPR‐Cas12a system makes it an excellent tool for disease diagnosis. Nevertheless, most methods based on CRISPR‐Cas still require pre‐amplification the target to achieve desired detection sensitivity. Here we generate Framework‐Hotspot reporters (FHRs) with different local densities investigate their effect activity Cas12a. We find that cleavage efficiency increases and rate accelerates increasing reporter density. further construct a modular sensing...
Berry firmness and total soluble solids (TSS) of three newly released highbush blueberry cultivars ('Draper', 'Liberty', 'Aurora') were evaluated in the 2005 growing season against popular commercial ('Duke', 'Bluecrop', 'Elliott') grown Northwest during after cold storage at temperatures between 1 to 4'C. These experiments conducted using berries from first pick a variety evaluation plot North Willamette Research Extension Center. was determined with FirmTech II tester. After durations 1,...
Abstract Lysophosphatidic acid receptor 5 (LPAR5) is involved in mediating thyroid cancer progression, but the underlying mechanism needs to be further revealed. In this study, we confirmed that LPAR5 upregulated papillary carcinoma (PTC), especially BRAF‐like PTC, by analyzing The Cancer Genome Atlas (TCGA) database and performing immunohistochemistry assay human tissues. LPAR5‐specific antagonist TC LPA5 4 treatment inhibited CGTH‐W3, TPC‐1, B‐CPAP, BHT‐101 cell proliferation, CGTH‐W3...
Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More more evidence shows that microRNAs are stable in serum specific to different tumor types. Therefore, miRNA a new non-invasive biomarker for detection.The experiment divided into three stages, namely, the screening stage, training verification stage. We took 54 patients nasopharyngeal 108 healthy controls as research objects. use...