A5011491975- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Micro and Nano Robotics
- Molecular Communication and Nanonetworks
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Cerebrospinal fluid and hydrocephalus
- Nanoplatforms for cancer theranostics
- Neurofibromatosis and Schwannoma Cases
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Microfluidic and Bio-sensing Technologies
- Renal cell carcinoma treatment
- Hepatitis B Virus Studies
- Eosinophilic Esophagitis
- Fibroblast Growth Factor Research
- Vascular Malformations and Hemangiomas
- Epigenetics and DNA Methylation
- Vascular Malformations Diagnosis and Treatment
- Bacteriophages and microbial interactions
Shantou University
2006-2024
Shantou University Medical College
2006-2024
Shenzhen Third People’s Hospital
2023-2024
Shenzhen University
2023-2024
Shenzhen University Health Science Center
2024
Shenzhen Luohu People's Hospital
2023
Peking University Shenzhen Hospital
2018-2022
Anhui Medical University
2022
University of Hong Kong - Shenzhen Hospital
2018-2020
Weatherford College
2020
Nanorobotic manipulation to access subcellular organelles remains unmet due the challenge in achieving intracellular controlled propulsion. Intracellular organelles, such as mitochondria, are an emerging therapeutic target with selective targeting and curative efficacy. We report autonomous nanorobot capable of active mitochondria-targeted drug delivery, prepared by facilely encapsulating mitochondriotropic doxorubicin-triphenylphosphonium (DOX-TPP) inside zeolitic imidazolate framework-67...
Motile microrobots open a new realm for disease treatment. However, the concerns of possible immune elimination, targeted capability and limited therapeutic avenue constrain its practical biomedical applications. Herein, biogenic macrophage-based microrobot loaded with magnetic nanoparticles bioengineered bacterial outer membrane vesicles (OMVs), capable propulsion, tumor targeting, multimodal cancer therapy is reported. Such cell robots preserve intrinsic properties macrophages suppression...
Autonomous nanorobots represent an advanced tool for precision therapy to improve therapeutic efficacy. However, current nanorobotic designs primarily rely on inorganic materials with compromised biocompatibility and limited biological functions. Here, we introduce enzyme-powered bacterial outer membrane vesicle (OMV) nanorobots. The immobilized urease the OMV catalyzes decomposition of bioavailable urea, generating effective propulsion This nanorobot preserves unique features OMVs,...
Bladder cancer, the ninth-most-common malignancy worldwide with an estimated 356,000 new cases and 145,000 deaths annually, has a propensity to relapse, requiring lifelong monitoring after diagnosis. 75% patients diagnosed BC are non-muscle invasive over 50% of them experience recurrences within 6-12 years initial miRNA small, noncoding RNA shown be oncogenes or anti-oncogenes in bladder contributing numerous cell processes, including proliferation, differentiation, migration...
Circulating miRNAs have been proved to be promising biomarkers for disease detection in recent years. The present study aimed at exploring available serum miRNA the of colorectal cancer.A three-phase was performed select and validate candidate with significant dysregulation cancer using quantitative reverse transcription-polymerase chain reaction. This recruited 137 patients 145 healthy controls. diagnostic values were evaluated by receiver operating characteristic analysis. Bioinformatics...
Background: Screening for colorectal carcinoma (CRC) lacks an efficient, inexpensive and noninvasive approach. The stable presence of serum miRNA is expected to become a new diagnostic marker. Materials & methods: Based on 135 CRC patients normal controls, this study was conducted in three phases identify suitable diagnosis by using quantitative reverse transcription PCR. Bioinformatic assays were used target genes prediction functional annotation. Results: Serum expression level seven...
Background: Bladder cancer is one of the most prevalent malignancies. Due to disadvantage existing bladder diagnostic tools, miRNAs hold promise as new markers. Materials & methods: A total 224 participants were involved in this three-cohort trial. 15 candidate selected, and with ability screened out quantitative reverse transcription PCR. Diagnostic capability was ascertained by receiver operating characteristic curve area under curve. Bioinformatics analysis constructed for target gene...
Previous research has shown that the miR-130 family is closely related to occurrence and development of bladder cancer. We hope use members as new, non-invasive, easily detectable biomarkers for cancer.We analyzed 428 cases in The Cancer Genome Atlas-Bladder Urothelial Carcinoma database verified were significantly overexpressed A total 74 cancer patients 90 controls enrolled. relative expression serum was detected using quantitative reverse transcription-polymerase chain reaction....
The aim of the study was to identify serum microRNAs (miRNAs) as potential biomarkers for screening renal cell carcinoma.The divided into three stages, including stage, training and validation stage. In we examined expression 30 miRNAs from healthy controls (HCs) carcinoma (RCC) patients. We further studied dysregulated in (30 RCC 26 HCs) (73 80 stages. estimated diagnostic value by receiver operating characteristic (ROC) curves area under ROC curve (AUC). Finally, bioinformatics analysis...
Aim: Breast cancer, especially invasive ductal carcinoma (IDC), is the cause of a great clinical burden. miRNA could be considered as noninvasive biomarkers for IDC diagnosis. Materials & methods: Two hundred and sixty participants (135 patients 125 healthy controls) were enrolled in three-cohort study. The expression 28 miRNAs serum detected with quantitative reverse transcription-PCR. Bioinformatic analysis was used predicting target genes three selected miRNAs. Results: level seven...
Bladder cancer (BC) is the tenth most common in world. Serum microRNA (miRNA) profiles previously have been reported as non-invasive biomarkers screening. The and reliable diagnostic are urgently needed for detecting BC, while cystoscopy invasive. Our study aimed to identify candidate miRNAs serum potential BC detection.This was including screening stage, training validation stage with 137 patients 127 healthy controls (HCs). We identified expression of 28 from 5 pools 3 HC initial stage....
Abstract Background: Prostate cancer (PCa) is one of the leading causes cancer-related death. In present research, we adopted a comprehensive bioinformatics method to identify some biomarkers associated with tumor progression and prognosis PCa. Methods: Differentially expressed genes (DEGs) analysis weighted gene co-expression network (WGCNA) were applied for exploring modules correlative Clinically Significant Modules distinguished, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...
miR-142-3p has proved to be involved in tumorigenesis and the development of renal cell carcinoma. The present study aimed explore prognostic value miR-142-3p.Total RNA was extracted from carcinoma specimens expression level measured. Pearson Chi-square test, Kaplan-Meier analysis, as well univariate multivariate regression analysis were performed determine correlation between prognosis patients. Receiver operating characteristic curves constructed evaluate predictive efficiency for Data...
Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More more evidence shows that microRNAs are stable in serum specific to different tumor types. Therefore, miRNA a new non-invasive biomarker for detection.The experiment divided into three stages, namely, the screening stage, training verification stage. We took 54 patients nasopharyngeal 108 healthy controls as research objects. use...
Artificial nanorobots have emerged as promising tools for a wide range of biomedical applications, including biosensing, detoxification, and drug delivery. Their unique ability to navigate confined spaces with precise control extends their operational scope the cellular or subcellular level. By combining tailored surface functionality propulsion mechanisms, demonstrate rapid penetration cell membranes efficient internalization, enhancing intracellular delivery capabilities. Moreover, robust...
Background. MicroRNAs (miRNAs) have been applied to cancer diagnosis taking into account their role in tumorigenesis. The main purpose of our study was confirm the possibility using miRNAs as noninvasive biomarkers for stomach adenocarcinoma (STAD) diagnosis. Methods. A total 246 participants (130 STAD patients and 116 healthy controls (HCs)) were enrolled this 3-phase study. Five pools 3 HC (with 4 each pool) used screening 28 quantitative reverse transcription-polymerase chain reaction...
Previous studies have shown that the miR-17-92 cluster is involved in occurrence and development of bladder cancer. However, role serum diagnosis cancer has not been studied. In present study, we evaluated expression members tissues by analyzing 428 cases from TCGA database. Next, collected sera 74 patients 90 controls, used qRT-PCR to detect relative cluster. The results showed were significantly higher than they positively correlated with clinical stage pathological grade patients. We...
Nasopharyngeal carcinoma (NPC) is notorious for the metastases, which are in close association with Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Arsenic trioxide (As2O3) has been shown to induce apoptosis and differentiation NPC xenografts. Then, can it repress cancer cells' metastasis potential? To elucidate this issue, present study was performed. LMP1-negative cell line HNE1 LMP1-positive HNE1-LMP1 were used as vitro model. Cells (1 x 10(5)/mL) cultured or without 3 µM...
The diagnosis of renal cell carcinoma (RCC) is often made late since there no early symptom, which thus results in dismal patient prognosis. As a result, new biomarkers are urgently needed and efforts should be to identify their functions predicting RCC microRNAs (miRNAs) class small noncoding RNAs that about 20-22 nucleotides length, they have been demonstrated function as prognostic markers numerous tumors. This study aimed assess the role miR-30b-5p prognosis postoperatively. In this...