A5006118477- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Renal and related cancers
- Adrenal and Paraganglionic Tumors
- Ferroptosis and cancer prognosis
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Testicular diseases and treatments
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Hormonal Regulation and Hypertension
- Soft tissue tumors and treatment
- Tuberous Sclerosis Complex Research
- Ovarian cancer diagnosis and treatment
- Urinary Bladder and Prostate Research
- Soft tissue tumor case studies
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Parasitic infections in humans and animals
- Male Reproductive Health Studies
Peking University Shenzhen Hospital
2015-2025
Shantou University Medical College
2020-2024
Shantou University
2020-2024
Anhui Medical University
2019-2023
Peking University
2014-2023
University of Hong Kong - Shenzhen Hospital
2013-2018
<b><i>Introduction:</i></b> The use of ketamine as a recreational drug is on the increase among young adults attending clubs and parties. Recreational users have anecdotally reported increased lower urinary tract symptoms while using substance. <b><i>Methods:</i></b> We describe severe experienced in 6 patients with chronic use. obtained detailed history physical examination along further investigation to identify relationship between these...
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, which associated with poor prognosis and high recurrence. Long non‑coding RNAs (lncRNAs) have been reported to be dysregulated important regulation carcinogenesis, thus suggesting that this class molecules may used as biomarkers cancer. The lncRNA urothelial 1 (UCA1) has observed upregulated function an oncogene certain types cancer; however, role UCA1 RCC remains elucidated. present study aimed determine...
MicroRNAs (miRNAs) are an important class of small, non‑coding RNA molecules that regulate gene expression at the transcriptional or post‑transcriptional level. They involved in apoptosis, proliferation and migration known to have role many types cancer. Aberrant miRNA‑451a (miR‑451a) has previously been reported tumors, however its renal cell carcinoma (RCC) is currently unknown. The aim present study was investigate miR‑451a RCC. analyzed 50 paired RCC normal tissues by quantitative...
microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of approximately 22 nucleotides in length that function as post-transcriptional gene regulators. Their aberrant expression may be involved human diseases, including cancer. Although miRNA-184 (miR-184) has been reported other tumors, its renal cell carcinoma (RCC) is still unknown. The aim the present study was to investigate role miR-184 RCC. impacts on migration, proliferation and apoptosis were...
microRNAs (miRNAs; miR) are a class of small non-coding RNA molecules, which involved in the pathogenesis human diseases through negative regulation gene expression. Previous studies have demonstrated that miR‑509‑3p is novel miRNA associated with cell proliferation and migration 786‑O renal carcinoma (RCC) cells. However, mechanism action RCC remains to be elucidated. The present study aimed examine functional role development RCC. results expression levels were downregulated ACHN lines...
Renal cell carcinoma (RCC) is the third most common cancer in urological system; however, pathogenesis remains unknown. Accumulating evidence has demonstrated that long non‑coding RNAs are dysregulated various tumors and serves an important role tumorigenesis development. In present study, expression of lncRNA differentiation antagonizing non‑protein coding RNA (DANCR) 24 paired RCC adjacent normal tissues was detected by reverse transcription‑quantitative polymerase chain reaction. The...
Urachal carcinomas are rare bladder malignances, which usually present at an advanced stage with a high risk of distant metastases and poor prognosis. To improve understanding this uncommon carcinoma, retrospective review was conducted for the cases observed Peking University Shenzhen Hospital First Hospital. The clinical outcomes were analyzed 17 patients diagnosis urachal cancer, who admitted to (Shenzhen, China) (Beijing, between 1998 2013. TNM staging system used predict outcomes. Among...
Background: Screening for colorectal carcinoma (CRC) lacks an efficient, inexpensive and noninvasive approach. The stable presence of serum miRNA is expected to become a new diagnostic marker. Materials & methods: Based on 135 CRC patients normal controls, this study was conducted in three phases identify suitable diagnosis by using quantitative reverse transcription PCR. Bioinformatic assays were used target genes prediction functional annotation. Results: Serum expression level seven...
Renal cell carcinoma (RCC) is one out of the most universal malignant tumors globally, and its incidence increasing annually. MicroRNA (miRNA) in serum could be considered as a non-invasive detecting biomarker for RCC diagnosis.A total 224 participants (112 patients (RCCs) 112 normal controls (NCs)) were enrolled three-phrase study. Reverse transcription quantitative PCR (RT-qPCR) was applied to reveal miRNA expression levels RCCs NCs. Receiver operating characteristic (ROC) curves area...
Abstract Background Although non-invasive radiological techniques are widely applied in kidney renal clear cell carcinoma (KIRC) diagnosis, more than 50% of KIRCs detected incidentally during the diagnostic procedures to identify (RCC). Thus, sensitive and accurate KIRC methods required. Therefore, this study, we aimed KIRC-associated microRNAs (miRNAs). Methods This three-phase study included 224 participants (112 each patients with healthy controls (NCs)). RT-qPCR was used evaluate miRNA...
Abstract Background To develop and compare machine learning models based on triphasic contrast-enhanced CT (CECT) for distinguishing between benign malignant renal tumors. Materials Methods In total, 427 patients were enrolled from two medical centers: Center 1 (serving as the training set) 2 external validation set). First, 1781 radiomic features individually extracted corticomedullary phase (CP), nephrographic (NP), excretory (EP) CECT images, after which 10 selected by minimum redundancy...
Renal cell carcinoma (RCC) is a common tumor of the urinary system. Previously, miR-191-5p has been reported to be associated with various types cancer; however, its specific functions in RCC have not investigated date. In present study, expression 786-O and ACHN lines was detected vitro by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The results RT-qPCR revealed that significantly downregulated two compared 293T line. also tissue paired normal tissue. addition,...
An increasing number of studies have demonstrated the function microRNAs (miRNAs) in initiation and development various types cancer. Among them, miR-425-5p is proven to serve an important several cancer, including gastric, cervical hepatocellular carcinoma. However, renal cell carcinoma (RCC) remains unclear. In present study, it was that expression level upregulated RCC tissues lines compared with normal (P<0.05). Additionally, Cell Counting kit-8 MTT assays were employed assess viability...
Renal cell carcinoma (RCC) is the most common type of malignant tumor adult kidney and has a poor prognosis. MicroRNAs (miRs) are important in wide range biological pathological processes, including differentiation, migration, growth, proliferation, apoptosis metabolism. The present study aimed to determine role exerted by miR‑30a‑5p tumorigenesis RCC. expression levels RCC tissues RCC‑derived cells were demonstrated be significantly downregulated real‑time quantitative polymerase chain...
MicroRNA (miR)-510-5p has been demonstrated to be involved in a number of types malignancy; however, the function miR‑510‑5p renal cancer remains unclear. The present study aimed determine expression cell carcinoma (RCC) specimens and analyzed impact on by 3-(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide, wound scratch apoptosis assays. results showed that was significantly downregulated RCC compared with normal specimens. Overexpression synthetic mature mimics reduced...
As influencing factors of genesis and progression in several types human tumor, microRNAs (miRs) serves roles the regulation tumor cell viability, migration, apoptosis. The present research aimed to investigate association between function miR‑100‑5p renal carcinoma (RCC). expression was determined RCC tissue paired normal samples using reverse transcription‑quantitative polymerase chain reaction. To assess effects on migration apoptosis, multiple methods were used, including scratch wound...
MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression metastasis of numerous cancer subtypes. However, potential role miR‑216a‑5p renal cell carcinoma (RCC) remains elucidated. In present study, reverse transcription‑quantitative polymerase chain reaction was performed detect expression levels RCC tissues. Cell counting kit‑8, MTT, wound scratch, Transwell flow cytometric assays were establish biological functions RCC. Functional experiments...
miR‑886‑3p has been discovered to be involved in the oncogenesis, progression and metastasis of several types human cancer. The aim present study was identify biological function clear cell renal carcinoma (ccRCC) determine its possible molecular mechanisms. found significantly upregulated ccRCC tissues (P<0.05), accordance with a previous sequencing result. Functional experiments revealed that forced downregulation inhibited cellular migration, suppressed proliferation induced apoptosis...
Renal angiomyolipoma (AML), also referred to as renal hamartoma, is a rare solid tumor without malignant characteristics. The inheritance pattern of AML autosomal dominant. If the lesion grows large size, series clinical manifestations and serious complications may occur. We herein present case giant in 34‑year‑old female patient, who presented with left‑sided abdominal bloating for ~6 months. Following ultrasound computed tomography examination, patient underwent total left nephrectomy....