A5008586673- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Soft tissue tumor case studies
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Bone health and treatments
- Soft tissue tumors and treatment
- Cancer Cells and Metastasis
- Urinary and Genital Oncology Studies
Peking University Shenzhen Hospital
2016-2024
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
Anhui Medical University
2022-2024
University of Hong Kong - Shenzhen Hospital
2024
Bladder cancer (BC) is one of the ten most common cancers worldwide with late detection and early age diagnosis. There abundant evidence that timely intervention can lead to a better prognosis BC. Substantial has indicated microRNAs (miRNAs) are specific different tumour types remarkably stable, indicating serum miRNAs may serve as potential diagnostic markers. This study aimed identify suitable create panel be used diagnose primary
Renal cell carcinoma (RCC) is a most common kidney malignancy, with atypical symptoms in the early stage and poor outcome late stage. Recently, emerging evidence revealed that some miRNAs play an essential role tumorigenesis progression of RCC. Therefore, aim this study understand detailed molecular mechanism miR-23a-3p RCC identify its potential clinical value.
Prostate cancer (PCa) remains a worldwide public health problem that poses serious threat to the of men worldwide. Many studies have found microRNA (miRNA) in serum has potential be biomarker for screening. Our study was conducted investigate value miRNAs PCa We selected 12 from past its association with PCa. checked expression levels these 112 patients and healthy controls two-stage experiment. plotted receiver operating characteristic curve validation stage constructed four-miRNA panel...
Background: Bladder cancer is one of the most prevalent malignancies. Due to disadvantage existing bladder diagnostic tools, miRNAs hold promise as new markers. Materials & methods: A total 224 participants were involved in this three-cohort trial. 15 candidate selected, and with ability screened out quantitative reverse transcription PCR. Diagnostic capability was ascertained by receiver operating characteristic curve area under curve. Bioinformatics analysis constructed for target gene...
Renal cell carcinoma (RCC) is one out of the most universal malignant tumors globally, and its incidence increasing annually. MicroRNA (miRNA) in serum could be considered as a non-invasive detecting biomarker for RCC diagnosis.A total 224 participants (112 patients (RCCs) 112 normal controls (NCs)) were enrolled three-phrase study. Reverse transcription quantitative PCR (RT-qPCR) was applied to reveal miRNA expression levels RCCs NCs. Receiver operating characteristic (ROC) curves area...
An increasing number of studies have demonstrated the function microRNAs (miRNAs) in initiation and development various types cancer. Among them, miR-425-5p is proven to serve an important several cancer, including gastric, cervical hepatocellular carcinoma. However, renal cell carcinoma (RCC) remains unclear. In present study, it was that expression level upregulated RCC tissues lines compared with normal (P<0.05). Additionally, Cell Counting kit-8 MTT assays were employed assess viability...
Background Bladder cancer (BC) is a common tumor worldwide. Screening for BC currently lacks highly efficient, non-invasive, and inexpensive method. Serum microRNA (miRNA), which stable commonly present, has the potential to serve as novel marker diagnosis. Materials &amp; methods Based on study involving 112 patients healthy subjects, we conducted this research in three phases identify applicable microRNAs (miRNAs) serum diagnosis using quantitative reverse transcription polymerase...
Background: Renal cell carcinoma (RCC) has been a major health problem and is one of the most malignant tumors around world. Serum microRNA (miRNA) profiles previously have reported as non-invasive biomarkers in cancer screening. The aim this study was to explore serum miRNAs potential for screening RCC. Methods: A three-phase conducted In phase, 12 candidate related RCC were selected further by ENCORI database with 517 patients 71 NCs. total 220 participants [108 112 normal controls (NCs)]...
Glomus tumors are rare and benign neoplasms, which normally originate from peripheral soft tissue. To date, reported cases of glomus tumor occurring in genitourinary tract, particularly the urethra, exceedingly rare. The present study presented a case anterior urethra 42 year‑old male, his main complaints were history pain for 3 years, palpable tender mass 2 weeks. Urethrocystoscopy examination resection urethral performed. Pathological immunohistochemical revealed that was tumor. patient...
Background Uroepithelial carcinoma is a serious threat to human health and causes heavy economic burden. Enhanced CT widely used in screening or preliminary diagnosis of uroepithelial tumors. However, false-positive results on enhanced can lead misdiagnosis incorrect endoscopy, while false-negative missed delayed treatment. There an urgent need find convenient, cost-effective non-invasive diagnostic methods reduce the rates The aim this study was evaluate value YiDiXie ™ -SS, -HS -D...
<title>Abstract</title> Prostate cancer is the fifth leading cause of male mortality and poses a serious threat to men's health worldwide. PSA testing widely used in prostate screening, but its high false-positive rate leads unnecessarily subsequent costs, mental anguish potential physical harm patients. Therefore, there an urgent need develop convenient, cost-effective non-invasive diagnostic method assist reducing screening. The aim this study was evaluate value serum MicroRNA expression...
Abstract Background Bladder cancer (BC) is one of the ten most common cancers in world with late detection and low age onset. There abundant evidence that for management BC, earlier timely intervention, better prognosis. Substantial indicates microRNAs (miRNAs) are specific to different tumor types have remarkable stability, so serum miRNAs can serve as potential diagnostic markers. Methods The samples including 112 BC patients non-cancer controls (NCs) were gathered research objects...
Abstract Background Prostate cancer remains a worldwide public health problem that poses serious threat to the of men worldwide. Many studies have found miRNA in serum has possible be biomarker for cancer. Our study was conducted investigate valuation miRNAs prostate screening. Methods We selected 12 from past associated with checked expression levels these 112 patients and healthy controls two-stage experiment. plotted receiver operating characteristic curve validation stage constructed...
目的： 探讨甲状腺透明变梁状肿瘤（HTT）的细针穿刺细胞病理学特征。 方法： 对5例HTT的临床、超声和细针穿刺细胞学形态进行观察，其中1例制备细胞蜡块，并行免疫组织化学检测。2例使用即时荧光定量PCR法进行BRAF V600E基因突变检测。 结果： 5例患者中女性4例，男性1例，发病年龄25~48岁。细针穿刺细胞涂片中可见肿瘤细胞呈放射状、梁状或巢状结构，肿瘤细胞与红染的玻璃样物质混杂。部分细胞胞质呈丝状，偶见黄色小体，细胞核圆形、卵圆形或梭形，可见多量核沟和核内假包涵体。1例细胞蜡块显示肿瘤细胞呈梁状结构，与玻璃样物质混合，细胞特征与涂片类似。Ki-67（MIB-1）免疫细胞化学染色肿瘤细胞呈特征性的膜质着色。2例使用即时荧光定量PCR法检测，均未发现BRAF V600E基因突变。 结论： HTT是一种罕见的甲状腺肿瘤，细胞形态与其他甲状腺肿瘤有重叠，在细针穿刺细胞病理诊断中非常容易被误诊。正确诊断的关键在于提高对该肿瘤的细胞病理形态的认识，制备细胞蜡块并行免疫组织化学检测具有重要的辅助诊断作用。.