A5101450004- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Hernia repair and management
- Testicular diseases and treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Gynecological conditions and treatments
- Pregnancy-related medical research
- MRI in cancer diagnosis
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Brain Tumor Detection and Classification
- Glioma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Soft tissue tumor case studies
- Pelvic floor disorders treatments
- Advanced Neuroimaging Techniques and Applications
- Cancer Mechanisms and Therapy
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
- Colorectal Cancer Surgical Treatments
- Breast Lesions and Carcinomas
Peking University Shenzhen Hospital
2024-2025
Anhui Medical University
2024-2025
University of Hong Kong - Shenzhen Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Peking Union Medical College Hospital
2008-2024
Shanghai Changzheng Hospital
2024
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
National Clinical Research Center for Digestive Diseases
2022
Erasmus MC Cancer Institute
2021
Annexin-1 was identified as an endometriosis-related protein by comparative proteomics in previous study. As endogenous anti-inflammatory mediator, has been shown to regulate the immune response, cell proliferation and apoptosis. To investigate whether is involved pathogenesis of endometriosis, we examined expression eutopic endometrium women with or without detected its peritoneal fluids those endometriosis.Eutopic samples from twenty-five endometriosis sixteen age-matched were collected....
Abstract Background There are limited studies on Sertoli-Leydig cell tumors (SLCTs) and no data in the population of Chinese patients with SLCTs from genetic level. In addition, previous have focused exclusively mutations DICER1 gene exists landscape SLCTs. Methods Patients moderately or poorly differentiated who underwent surgical resection between January 2012 October 2018 our institution were recruited. Whole exome sequencing was performed formalin-fixed, paraffin-embedded tumor tissue...
Ovarian clear cell carcinoma (OCCC) is a distinct entity from epithelial ovarian cancer. The prognosis of advanced and recurrent disease very poor due to resistance chemotherapeutic agents. Our aim was explore the molecular alterations among OCCC patients with different responses obtain insights into potential biomarkers.Twenty-four were included in this study. divided two groups based on relapse time after first-line platinum-based chemotherapy: platinum-sensitive group (PS)...
Abstract Purpose This study investigated the clinicopathological features and surgical procedures of adnexal masses with abdominal pain in pediatric adolescent patients. Our objective was to better define clinical presentation torsion distinguish characteristics those an alternate diagnosis. Methods Retrospective cohort 212 patients performed who admitted for presenting mass between March 2012 December 2019.Medical records were reviewed age at operation, including symptoms signs; levels...
Ovary benign clear cell adenofibroma (CCAF) is extremely rare. Here, we reported a 38-year-old woman with CCAF who was given sequential cyclic hormone replacement therapy for eight years due to premature ovarian failure (POF). At operation, found adenofibromas in both ovaries and well encapsulated. The cut surface cystic solid appearance, multilocular cysts embedded hard stroma. Determination of sex levels the fluid ovary showed normal level. Clear cystadenofibroma proliferation stroma while...
Background Breast cancer is a serious threat to women’s health and breast screening of great importance. ultrasound or mammography widely used for diagnosis tumors, However, false-positive mammogram results can lead misdiagnosis wrong puncture biopsy, while false-negative missed delayed treatment. There an urgent need find convenient, cost-effective noninvasive method reduce the rate mammography. The aim this study was evaluate diagnostic value YiDiXie™-SS, YiDiXie™-HS YiDiXie™-D in cancer....
Background Thyroid tumor, as an endocrine tumor with increasing incidence, causes a heavy economic burden. ultrasound is widely used for screening or diagnosis of thyroid tumors. However, false-positive results can lead to misdiagnosis and wrong puncture biopsy, while false-negative missed delayed treatment. There urgent need find convenient, cost-effective non-invasive diagnostic method reduce the rates ultrasound. The aim present study was evaluate value YiDiXie™-SS, YiDiXie™-HS YiDiXie™-D...
Background Pancreatic cancer is a serious threat to human health. Enhanced CT widely used in the diagnosis of pancreatic cancer. However, false-positive results on enhanced can lead misdiagnosis and incorrect surgery or treatment, while false-negative missed delayed treatment. There an urgent need find convenient, cost-effective non-invasive diagnostic methods reduce rates tumors. The aim this study was evaluate value YiDiXie™-SS, YiDiXie™-HS YiDiXie™-D Patients 62 subjects (malignant group,...
<title>Abstract</title> Prostate cancer is the fifth leading cause of male mortality and poses a serious threat to men's health worldwide. PSA testing widely used in prostate screening, but its high false-positive rate leads unnecessarily subsequent costs, mental anguish potential physical harm patients. Therefore, there an urgent need develop convenient, cost-effective non-invasive diagnostic method assist reducing screening. The aim this study was evaluate value serum MicroRNA expression...
Background Brain malignant tumors is a serious threat to human health and causes heavy economic burden. Enhanced MRI widely used in the diagnosis of brain tumors. However, false-positive results enhanced will lead misdiagnosis incorrect surgery or treatment, while false-negative underdiagnosis delayed treatment. There an urgent need find convenient, cost-effective non-invasive diagnostic methods reduce rates brain-enhanced MRI. The aim this study was evaluate value YiDiXie™-SS, YiDiXie™-HS...
Background Gastric cancer poses a severe risk to public health and has substantial financial impact. Tumor markers such as CEA, CA125, CA19-9, others, well the fecal occult blood test (FOBT), are frequently utilized for gastric screening initial diagnosis. However, false-positive results of FOBT, CA19-9 can lead misdiagnosis erroneous gastroscopy, while their false-negative missed diagnosis delayed treatment. Finding practical, affordable, non-invasive diagnostic techniques is crucial...
Background: Endometrial cancer represents a significant challenge to human health and is associated with considerable economic burden. Ultrasound commonly employed modality in the screening preliminary diagnosis of endometrial cancer. However, false-positive ultrasound results can lead misdiagnosis, patients have bear unnecessary distress, expensive examination costs, injuries other adverse consequences; while false-negative will result delayed treatment, thus consequences poor prognosis,...
The study aimed to establish humanized patient-derived xenograft (PDX) mouse models of ovarian clear cell carcinoma (OCCC) and evaluate their therapeutic responses.
Objective To investigate the clinical characteristics of preadolescent and adolescent female patients with ovarian mass combined dysplasia secondary sexual characteristics. Methods This study retrospectively analyzed 18 cases aged 0-19 years admitted to Peking Union Medical College Hospital from January 2012 November 2019.By analyzing manifestations,surgical methods,postoperative pathology,therapies prognosis cases,we summarized diagnosis treatment ideas. Results Among...
<h3>Introduction</h3> This study investigated the clinicopathological features and surgical procedures of adnexal masses with abdominal pain in pediatric adolescent patients. <h3>Methods</h3> Retrospective cohort 212 patients was performed who admitted for presenting an mass between March 2012 to December 2019 <h3>Results</h3> The proportion presented acute onset pain, persistent or recurrent duration less than 3 months significantly higher TO group non-TO (P < 0.001). 69.2% torsion had...
Abstract ObjectivesThis retrospective study aimed to evaluate the clinical characteristics and prognosis of ovarian clear cell carcinoma (OCCC) further explore monitoring value cancer antigen 125 (CA-125).MethodsThe medical records 112 OCCC patients who were treated in Peking Union Medical College Hospital (PUMCH) between 2014 2019 collected reviewed, data such as age, Federation Gynecology Obstetrics (FIGO) stage, CA-125 level, treatment, recurrence, death extracted.OutcomesThe median...
<h3>Objectives</h3> Treatment options for platinum resistant or refractory recurrent ovarian cancer (PRR OC) are few and therapeutic efficacy limited especially those after 1 prior line of platinum-based chemotherapy. So, we designed a Phase II trail to evaluate the safety niraparib combined with oral etoposide in PRR OC. <h3>Methods</h3> Key eligibility criteria include patients histologically confirmed non-mucinous epithelial ovarian, fallopian tube, primary peritoneal carcinoma; 1–2 lines...
Abstract Objectives: The study aimed to explore the rate of upstaging after surgical staging in patients with apparent International Federation Gynecology and Obstetrics (FIGO) stage I ovarian mucinous carcinoma. Methods: Ovarian carcinoma treatment were, retrospectively, reviewed Peking Union Medical College Hospital between October 2020 January 1994. Results: Totally, 163 were included this study, Surgical re-staging was performed 89 incomplete one-step 74 patients. For these incompletely...
Abstract Objective: To investigate the clinicopathological features and surgical procedures of adnexal masses with abdominal pain in pediatric adolescent patients. Methods: A total 212 who underwent surgery were retrospectively reviewed. The patients divided into two groups, namely, emergency (EMS, n=96) group elective (ELS, n=116) group, according to whether they had been surgically diagnosed conditions. EMS refers conditions including torsion，corpus luteum rupture，and rupture ectopic...