A5101418409- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Bone Tissue Engineering Materials
- Ovarian cancer diagnosis and treatment
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Electrospun Nanofibers in Biomedical Applications
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- MicroRNA in disease regulation
- Wound Healing and Treatments
- Pancreatic and Hepatic Oncology Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cellular Mechanics and Interactions
- Polymer Nanocomposite Synthesis and Irradiation
- Endometrial and Cervical Cancer Treatments
- Pelvic and Acetabular Injuries
- Colorectal and Anal Carcinomas
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Nanjing University
2025
Suzhou University of Science and Technology
2017-2024
Army Medical University
2014-2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Dalian Medical University
2024
Xi'an Jiaotong University
2023-2024
Jilin University
2019-2023
Abstract Background Hypoxia is a major cause of beta cell death and dysfunction after transplantation. The aim this study was to investigate the effect exosomes derived from mesenchymal stem cells (MSCs) on under hypoxic conditions potential underlying mechanisms. Methods Exosomes were isolated conditioned medium human umbilical cord MSCs identified by WB, NTA, transmission electron microscopy. Beta (βTC-6) cultured in serum-free presence or absence 2% oxygen conditions. Cell viability...
Integrin-mediated cell-matrix adhesion plays an important role in control of cell behavior. We report here that MIG-2, a widely expressed focal protein, interacts with β1 and β3 integrin cytoplasmic domains. Integrin binding is mediated by single site within the MIG-2 FERM domain. Functionally, MIG-2/integrin interaction recruits to adhesions. Furthermore, using αIIbβ3 integrin-expressing Chinese hamster ovary cells, well described model system for activation, we show promotes activation...
The 2023 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) antiphospholipid syndrome (APS) classification criteria were developed with higher specificity but lower sensitivity compared the 2006 Sydney revised criteria.
Kindlin-2 is a FERM and PH domain-containing integrin-binding protein that emerging as an important regulator of integrin activation. How kindlin-2 functions in activation, however, not known. We report here interacts with multiple phosphoinositides, preferentially phosphatidylinositol 3,4,5-trisphosphate. Although essential for focal adhesion localization kindlin-2, phosphoinositide-binding required this process. Using biologically clinically relevant glomerular podocytes model system, we...
The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome.We recruited all patients presenting Peking Union Medical College Hospital from 2004 2015 diagnosed with syndrome. medical data, test results imaging were collected for patients.One hundred sixty-four (111 women 53 men) our cohort. mean age 40.71 years. Nine had osteoarticular symptoms without skin involvement. One forty-three 25 palmoplantar pustulosis severe acne, respectively. Psoriasis vulgaris...
There remains a lack of effective and noninvasive methods for the diagnosis prognosis prediction epithelial ovarian carcinoma (EOC). Here, we investigated possibility serum-derived small extracellular vesicle (sEV) microRNAs (miRNAs) as potential biomarkers distinguishing between benign malignant adnexal masses predicting EOC patients. A serum sEV miRNA model identifying (sEVmiR-EOC) was successfully established in training cohort. Furthermore, sEVmiR-EOC confirmed testing cohort validation...
The EGFR and HER2 genes are located on chromosomes 7 17, respectively. They therapeutic targets in some tumors. TOP2A gene, which is near chromosome the target of many chemotherapeutic agents, co-amplification has been described several tumor types. Herein, we investigated gene status EGFR, HER2, Chinese gastric carcinoma patients. We determined rate polysomy for attempted to clarify relationship between copy number increased expression their encoded proteins. Furthermore, tried address...
Tumour necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial chaperone that plays role in maintaining function and regulating cell apoptosis. The opening of the permeability transition pore (MPTP) key step death after hypoxia. However, it still unclear whether TRAP1 protects cardiomyocytes from hypoxic damage by pore. In present study, primary cultured neonatal rats were used to investigate changes expression hypoxia treatment as well mechanism effect on damage. results...
Lung adenocarcinoma (AD) is a common variant of non-small cell lung cancer (NSCLC). Programmed death protein 1/programmed ligand 1 (PD1/PD-L1) are promising immunotherapy targets and its expression may be an important biomarker predicting clinical response. In this study, we evaluated PD-L1 in conjunction with clinicopathological characteristics outcomes resected adenocarcinoma.This study included 133 cases adenocarcinoma. rate was 16.5% at the mRNA level 13.5% level, kappa coefficient two...
Lung adenosquamous cell carcinomas (ASCs) is a rare variant of NSCLC with poorer prognosis and fewer treatment option than the more common variants. PD-L1 expression reported to be predictor clinical response in trials NSCLC. In our study, was evaluated via immunohistochemistry using specific monoclonal antibody (SP263), mRNA situ hybridization. This study included 51 ASCs, 133 lung adenocarcinomas, 83 squamous (SCC). Similar results were obtained for measured at protein level (k...
Abstract Colorectal cancer stem cell (CSC) has been regarded to be the root of colorectal progression. However, there is still no effective therapeutic method targeting CSC in clinical application. Here, we investigated effects dichloroacetate (DCA) on stemness. We showed that DCA could reduce stemness a dose‐dependent manner, which evident by decreased expression markers, tumor sphere‐formation and migration ability. In addition, it was found trigerred ferroptosis CSC, characterized as...
Stroke is a leading cause of morbidity and mortality worldwide. As the most common type stroke cases, treatment effectiveness still limited despite intensive research. Recently, traditional Chinese medicine has attracted attention because potential benefits for treatment. Among these, luteolin, natural plant flavonoid compound, offers neuroprotection following against ischemic stroke, although specific mechanisms are unknown. Here we used network pharmacology, molecular docking, experimental...
Mesenchymal epithelial transition (MET) factor alteration in non-small cell lung cancer (NSCLC) includes MET exon 14 skipping (METex14 skipping), gene amplification, mutation (mainly kinase domain mutation), fusion, and protein overexpression. The incidence of METex14 patients with NSCLC is 0.9–4.0%. At present, drugs targeting have been approved China other countries like Japan USA. Patients advanced should undergo testing, including skipping, to screen the population benefit from targeted...
A novel intumescent flame retardant poly(butylene succinate) (IFR‐PBS) with antidripping property was prepared using halloysite nanotubes (HNTs) as the synergistic agent. Ammonium polyphosphate (APP), melamine (MA), pentaerythritol (PER), and were added in PBS via melt blending. The effects of HNTs agent on retardancy property, thermal mechanical IFR‐PBS composites investigated. Cone calorimetry revealed that partial substitution IFR by (1.5 wt%) substantially improved a reduction heat...
The clinical application of next-generation sequencing technologies has offered a more comprehensive understanding the mutational profile tumor samples. study was aimed to evaluate feasibility NextDaySeq-Lung panel, which is an NGS-based assay for mutation analysis key driver genes in lung cancer, setting.A total 138 FFPE samples non-small cell cancer (NSCLC) were examined parallel with assays developed on (NGS), quantitative PCR (QPCR), and Sanger (Sanger) platforms somatic mutations EGFR,...
Background and Aim Poor response to immune checkpoint inhibitors (ICIs) has been observed in most triple-negative breast cancer (TNBC) cases (around 80%). Our aim was investigate the status of mismatch repair (MMR), microsatellite instability (MSI), programmed death-ligand 1 (PD-L1), lymphocyte-activation gene 3 (LAG-3) TNBC. Methods A total 74 TNBC samples were retrospectively analyzed. MMR MSI evaluated by immunohistochemistry (IHC) polymerase chain reaction (PCR) using Promega 1.2 NCI...
Cerebral ischemic stroke (CIS) is an acute cerebrovascular disease that caused by the sudden rupture of blood vessels inside brain and intervention reperfusion to brain, resulting in severe cerebral injury. Autophagy has been reported be involved occurrence progression CIS. Betulinic acid (BA) a pentacyclic triterpene mainly extracted from birch bark. Studies have shown neuroprotective effects BA. Here, effect mechanism BA on ischemia-reperfusion induced injury was explored using CIS model...
Systemic lupus erythematosus (SLE) is frequently associated with a lower rate of live birth and higher incidence adverse pregnancy outcomes (APOs), can also increase the risk SLE flares. Comprehensive preconception assessment critical for improved in patients SLE. Unfortunately, no global consensus on conditions that should fulfill prior to has yet been formed. This study aimed investigate before optimize outcomes. was retrospective utilizing data from multicenter Chinese cohort. Information...