A5040174397- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Connective tissue disorders research
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Congenital heart defects research
- Management of metastatic bone disease
- Genetic factors in colorectal cancer
- Orthopedic Infections and Treatments
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Neurofibromatosis and Schwannoma Cases
- TGF-β signaling in diseases
- Hip disorders and treatments
- Spinal Dysraphism and Malformations
- Cardiac, Anesthesia and Surgical Outcomes
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Bone health and treatments
- Bone Metabolism and Diseases
- Lower Extremity Biomechanics and Pathologies
Jiangsu Hengrui Medicine (China)
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Peking Union Medical College Hospital
2015-2024
Academy of Medical Sciences
2011-2024
Jingdong (China)
2024
John Wiley & Sons (Germany)
2024
Academia Sinica
2018-2019
National Natural Science Foundation of China
2013-2017
Creative Commons
2017
Union Hospital
2005-2013
Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis.
Both magnetic nanoparticles (MNPs) and exosomes derived from bone mesenchymal stem cells (BMSC-Exos) have been reported to improve wound healing. In this study, novel (mag-BMSC-Exos) would be fabricated BMSCs with the stimulation of MNPs a static field (SMF) further enhance repair.Mag-BMSC-Exos, namely, preconditioned Fe3O4 SMF, together BMSC-Exos were both first isolated by ultracentrifugation, respectively. Afterwards, we conducted in vitro experiments, including scratch assays, transwell...
IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 T-bet double-deficient identified the Th2 transcription factor c-Maf to be synergistically up-regulated IL-6 plus TGFbeta associated with production. Both induction during polarization depended Stat3, but not or Stat1, mechanistically differed from regulation IL-27 signals. was also synergistic induce c-Maf, it induced Stat1-independent expression in contrast alone....
Aberrant proliferation of nucleus pulposus cell is implicated in the pathogenesis intervertebral disc degeneration. Recent findings revealed that microRNAs, a class small noncoding RNAs, could regulate many pathological conditions. Here, we showed miR-10b was dramatically upregulated degenerative tissues when compared with isolated from patients idiopathic scoliosis. Moreover, levels were associated degeneration grade and downregulation HOXD10. In cultured cells, overexpression stimulated...
Using an improved method, the multilayer fermentation bacterial cellulose (BC) was produced by Gluconacetobacter xylinus. The structure and morphology were analysed electronic microscope. surface area tensile strength characterised. In vitro, cytotoxicity of BC determined proliferation, adhesion property, morphology, viability human adipose-derived stem cells (hASCs). Full-thickness skin wounds made on backs 35 mice. subsequently treated with two types gauzes, films, three grafts using 5...
Retrospective study of a series 226 consecutive Chinese patients with congenital scoliosis.To identify the incidence intraspinal abnormalities and other organ defects in surgical scoliosis population.Previous studies have revealed high rates anomalies scoliosis. The population has not been reported.A total underwent treatment Peking Union Medical College Hospital between January 2005 March 2011 were identified. A definitive diagnosis for all was made. Complete data reviewed, including...
Increasing evidence suggests that obesity and aberrant proliferation of nucleus pulposus (NP) cells are associated with intervertebral disc degeneration. Leptin, a hormone increased circulating level in obesity, has been shown to stimulate cell tissue-dependent manner. Nevertheless, the effect leptin on human NP not yet demonstrated. Here, we show induced primary cultured cells, which expressed receptors OBRa OBRb. Induction was confirmed by CCK8 assay immunocytochemistry Real-time PCR for...
Retrospective review.To evaluate the efficacy of multimodal intraoperative neuromonitoring for predicting iatrogenic neurological injury during surgical correction a spine deformity and potential risk factors monitoring changes.Single modal is insufficient to predict deformity. Multimodal can provide more accuracy. Some were reported be correlated with high rates deficits scoliosis correction. But few studies have on changes (NMCs).The records 176 consecutive patients who underwent surgery...
Abstract Cartilage‐derived mesenchymal stem cells (MSCs) have been isolated with different methods. In this study lateral and medial femoral condyles were respectively collected from patients late‐stage osteoarthritis during the total knee arthroplasty. After digestion of cartilage tissues type II collagenase analysis by fluorescence‐activated cell sorting (FACS) CD146, a chondroprogenitor sub‐population purified. The expression other MSC‐associated markers in CD146 + chondroprogenitors was...
Recently, 3D printing as effective technology has been highlighted in the biomedical field. Previously, a porous hydroxyapatite (HA) scaffold with biocompatibility and osteoconductivity developed by this method. However, its osteoinductivity is limited. The main purpose of study was to improve it introduction recombinant human bone morphogenetic protein-2 (rhBMP-2). This coating rhBMP-2-delivery microspheres collagen. These synthesized scaffolds were characterized Scanning Electron...
The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome.We recruited all patients presenting Peking Union Medical College Hospital from 2004 2015 diagnosed with syndrome. medical data, test results imaging were collected for patients.One hundred sixty-four (111 women 53 men) our cohort. mean age 40.71 years. Nine had osteoarticular symptoms without skin involvement. One forty-three 25 palmoplantar pustulosis severe acne, respectively. Psoriasis vulgaris...
Background Early-onset scoliosis (EOS), defined by an onset age of less than 10 years, conveys significant health risk to affected children. Identification the molecular aetiology underlying patients with EOS could provide valuable information for both clinical management and prenatal screening. Methods In this study, we consecutively recruited a cohort 447 Chinese operative EOS. We performed exome sequencing (ES) screening on these individuals their available family members (totaling 670...