A5033423640- Sepsis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Plant Gene Expression Analysis
- Immune Response and Inflammation
- Acute Kidney Injury Research
- Circular RNAs in diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammation biomarkers and pathways
- Inflammasome and immune disorders
- Plant Molecular Biology Research
- Machine Learning in Healthcare
- RNA modifications and cancer
- Cancer-related gene regulation
- Venous Thromboembolism Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Sirtuins and Resveratrol in Medicine
- Protein Degradation and Inhibitors
China Medical University
2016-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Nanjing Agricultural University
2022-2025
Shandong University of Traditional Chinese Medicine
2024
Shaanxi Provincial People's Hospital
2023
Shanxi Medical University
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2021
University of Birmingham
2020
Shandong Mental Health Center
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
1996
Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis.
Myocardial injury resulting from sepsis is the leading cause of death worldwide. Micro RNA miR-122-5p involved in various physiological and pathological processes highly expressed heart septic rats. However, its function sepsis-caused myocardial remains elusive. Herein, a rat model was established by intraperitoneal injection lipopolysaccharide (LPS), cardiomyocyte H9c2 exposed to LPS induce sepsis-related inflammatory vitro. Inhibition suppressed LPS-triggered evidenced decreased weight...
The circadian clock refers to the formation of a certain rule in long-term evolution an organism, which is invisible ‘clock’ body organism. As one largest TF families higher plants, MYB transcription factor involved plant growth and development. also inextricably correlated with rhythm. In this study, transcriptome data tea ‘Baiyeyihao’ were measured at photoperiod interval 4 h (24 h). A total 25,306 unigenes obtained, including 14,615 that annotated across 20 functional categories within GO...
Inflammatory diseases, including infectious diabetes-related arthritis-related neurological digestive and tumor, continue to threaten human health impose a significant financial burden despite advancements in clinical treatment. Pyroptosis, pro-inflammatory programmed cell death pathway, plays an important role the regulation of inflammation. Moderate pyroptosis contributes activation native immunity, whereas excessive is associated with occurrence progression Pyroptosis complicated tightly...
Septic shock with heart dysfunction is very common in intensive care units. However, whether long noncoding RNA (lncRNA) and mRNA profiles differ between patients without myocardial depression unknown. We generated rat models of hypodynamic septic induced by lipopolysaccharide. A total 12 was constructed tissue from each collected. Whole genomic sequencing performed on left ventricular tissue; 6,508 novel lncRNAs 432 annotated were identified samples, 74 expressed differently the sepsis...
Acute kidney injury (AKI) is a complex syndrome with an abrupt decrease of function, which associated high morbidity and mortality. Sepsis the common cause AKI. Mounting evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in development progression sepsis-induced In this study, we aimed to illustrate function mechanism lncRNA SNHG14 lipopolysaccharide (LPS)-induced We found was highly expressed plasma sepsis patients inhibited cell proliferation autophagy...
BACKGROUND: Intracellular Ca 2+ cycling governs effective myocardial systolic contraction and diastolic relaxation. SERCA2a (sarco/endoplasmic reticulum ATPase type 2a), which plays a crucial role in controlling intracellular signaling cell function, is downregulated inactivated during sepsis-induced heart dysfunction. However, the cause of this dysregulation remains unclear. In study, we investigated effect lysine succinylation lipopolysaccharide-induced septic dysfunction through global...
Theanine, a unique non-protein amino acid, is specifically accumulated in tea plants during winter. This study explored the theanine accumulation patterns ‘Longjing 43’ and ‘Huangjinya’ under different N supply conditions analyzed expression of genes involved biosynthesis winter dormancy. We found that two plant cultivars shared similar After 30 d cultivation with various forms deficiency, content tissues both was highest control group, followed by NH4+ treatment. Furthermore, we noted root...
Lignin is an aromatic polymer that provides the necessary mechanical strength for transport of water and nutrients in higher plants. biosynthesis accumulation affect growth development tea plant. The degree lignification related to tenderness fresh leaves determines quality tea. WRKY transcription factors play central roles plant physiological processes. However, lignin remain unclear. In this study, a gene, <i>CsWRKY13</i>, was cloned from 'Longjing 43'. open reading frame (ORF)...
The circadian clock, also known as the rhythm, is responsible for predicting daily and seasonal changes in environment, adjusting various physiological developmental processes to appropriate times during plant growth development. clock controls expression of Lhcb gene, which encodes chlorophyll a/b binding protein. However, roles gene tea remain unclear.
Septic shock with low cardiac output is very common in children. However, the mechanism underlying myocardial depression unclear. The role of β<sub>3</sub>-AR development sepsis unknown. In present study, we generated an adolescent rat model hypodynamic septic induced by lipopolysaccharide (LPS). Neonatal cardiomyocytes were also treated LPS to mimic sepsis, which was confirmed via vivo left ventricular hemodynamic and measurements contractility Ca<sup>2+</sup>...
It is generally accepted that insulin exerts an antiapoptotic effect against ischemia/reperfusion through the activation of PI3K/Akt/mTOR pathway. MicroRNAs involve in multiple cardiac pathophysiological processes, including ischemia/reperfusion–induced injury. However, regulation microRNAs cardioprotective rarely discussed. In this study, using a cell model ischemia culturing H9C2 myocytes serum‐free medium with hypoxia, we demonstrated pretreatment significantly inhibited apoptosis and...