A5101837684- Congenital heart defects research
- Zebrafish Biomedical Research Applications
- Catalytic Processes in Materials Science
- Congenital Heart Disease Studies
- Developmental Biology and Gene Regulation
- Cardiomyopathy and Myosin Studies
- Renal and related cancers
- Coronary Artery Anomalies
- Advanced Photocatalysis Techniques
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Cardiac Fibrosis and Remodeling
- Single-cell and spatial transcriptomics
- Genetic and Kidney Cyst Diseases
- Advanced oxidation water treatment
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Caching and Content Delivery
- Ammonia Synthesis and Nitrogen Reduction
- Genetics and Neurodevelopmental Disorders
- Gas Sensing Nanomaterials and Sensors
- Birth, Development, and Health
- Neonatal Respiratory Health Research
East China Normal University
2017-2025
Sun Yat-sen University
2022-2025
Guangdong Provincial Academy of Environmental Science
2025
Zhongda Hospital Southeast University
2024
Guangzhou Institutes of Biomedicine and Health
2024
Chinese Academy of Sciences
2024
Nanjing Drum Tower Hospital
2024
Shanghai East Hospital
2024
Nantong University
2024
Zhengzhou University
2023
Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis.
The heart needs blood vessels, too For the newborn to grow quickly, heart's own vessels must as well. Researchers have assumed that preexisting fetal coronary expand cause this postnatal vascular growth. Instead, Tian et al. now show that, for most part, brandnew form within neonatal (see Perspective by Burns and Burns). This ability produce new after birth may one day help researchers work out how promote cardiovascular regeneration injury or disease. Science , issue p. 90 ; see also 28
Abstract Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly secreted by the osteoblast lineage in subchondral bone tissue of osteoarthritis (OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, identification novel drug targets PGE2 signaling progression urgently needed. Osteoclasts play critical role homeostasis and OA-related pain. mechanisms which regulates osteoclast function subsequently are largely...
The design of a micro-/nanoreactor is great significance for catalytic ozonation, which can achieve effective mass transfer and expose powerful reaction species. Herein, the mesoporous carbon with atomic Fe-N4 sites embedded in ordered nanochannels (Fe-N4/CMK-3) was synthesized by hard-template method. Fe-N4/CMK-3 be employed as nanoreactors preferred electronic geometric microenvironments internal ozonation CH3SH. During CH3SH oxidation process, coefficient confined system sufficient O3...
Coronary arteries bring blood flow to the heart muscle. Understanding developmental program of coronary provides insights into treatment artery diseases. Multiple sources have been described as contributing including proepicardium, sinus venosus (SV), and endocardium. However, origins vessels are still under intense study. We produced a new genetic tool for studying development, an AplnCreER mouse line, which expresses inducible Cre recombinase specifically in developing vessels....
Mutations in Notch2, Jagged1 or homologs of the Hairy-related transcriptional repressor Hey2 cause congenital malformations involving non-chamber atrioventricular canal (AVC) and inner curvature (IC) regions heart, but underlying mechanisms have not been investigated. By manipulating signaling directly within developing chick we demonstrated that Hey1 initiate a cascade delimits AVC IC regions. Specifically, misactivation Notch2 signaling, misexpression either Hey2, repressed Bmp2. Because...
High-performance and robust catalysts act as core drivers for catalytic ozonation to eliminate gaseous sulfur-containing volatile organic compounds (VOCs). Herein, nitrogen-doped carbon nanotubes embedded with Co species (Co@NCNT) are synthesized by thermolysis of a ZIF-67/melamine mixture. The carbon-confinement effects in Co@NCNT not only improve the stability but also regulate electronic structure Co─C bonds, consequently synergistically improving performance. experimental results...
The advancement of atomically precise dinuclear heterogeneous catalysts holds great potential in achieving efficient catalytic ozonation performance and contributes to the understanding synergy mechanisms during reaction conditions. Herein, we demonstrate a “ship-in-a-bottle pyrolysis” strategy that utilizes Fe 2 (CO) 9 dinuclear-cluster precisely construct site, consisting two 1 -N 3 units connected by Fe-Fe bonds firmly bonded N-doped carbon. Systematic characterizations theoretical...
Energy deprivation and metabolic rewiring of cardiomyocytes are widely recognized hallmarks heart failure. Here, we report that HEY2 (a Hairy/Enhancer-of-split-related transcriptional repressor) is upregulated in hearts patients with dilated cardiomyopathy. Induced Hey2 expression zebrafish or mammalian impairs mitochondrial respiration, accompanied by elevated ROS, resulting cardiomyocyte apoptosis Conversely, depletion adult mouse enhances the oxidation genes cardiac function. Multifaceted...
Abstract Cardiac regeneration involves the generation of new cardiomyocytes from cycling cardiomyocytes. Understanding cell-cycle activity pre-existing provides valuable information to heart repair and regeneration. However, anatomical locations in situ dynamics remain unclear. Here we develop a genetic approach for temporally seamless recording cardiomyocyte-specific vivo. We find that majority are positioned subendocardial muscle left ventricle, especially papillary muscles. Clonal...
Abstract Base editors, including dual base are innovative techniques for efficient conversions in genomic DNA. However, the low efficiency of A-to-G conversion at positions proximal to protospacer adjacent motif (PAM) and A/C simultaneous editor hinder their broad applications. In this study, through fusion ABE8e with Rad51 DNA-binding domain, we generate a hyperactive ABE (hyABE) which offers improved editing region (A 10 -A 15 ) PAM, 1.2- 7-fold improvement compared ABE8e. Similarly,...
Abstract In the quest to boost intrinsic activity of single‐atom catalysts (SACs), optimizing electronic properties metal centers and maximizing active sites play a pivotal role. Here, facile surface molten salt‐assisted approach for fabricating porous iron‐nitrogen‐carbon enriched with catalytically accessible motifs is reported. Multiple characterization analyses prove that abundant defects are generated at edge sites, resulting in formation thermally stable unstitched Fe‐N 3 motif....
Articular cartilage repair and regeneration is an unmet clinical need because of the poor self-regeneration capacity tissue. In this study, we found that expression prostaglandin E receptor 4 (PTGER4 or EP4) was largely increased in injured articular both humans mice. microfracture (MF) surgery-induced defect (CD) destabilization medial meniscus (DMM) CD mouse models, cartilage-specific deletion EP4 remarkably promoted tissue by enhancing chondrogenesis anabolism, suppressing catabolism...
Mutagenesis screening is a powerful genetic tool for probing biological mechanisms underlying vertebrate development and human diseases. However, the increased colony management efforts in vertebrates impose significant challenge identifying genes affecting particular organ, such as heart, especially those exhibiting adult phenotypes on depletion.We aim to develop facile approach that streamlines via enriching cardiac mutants, which enables us screen phenotypes.The transparency of zebrafish...