A5053097589- Effects and risks of endocrine disrupting chemicals
- Growth Hormone and Insulin-like Growth Factors
- Drug Transport and Resistance Mechanisms
- Bioinformatics and Genomic Networks
- Chemical Analysis and Environmental Impact
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Pituitary Gland Disorders and Treatments
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Sirtuins and Resveratrol in Medicine
- Ginseng Biological Effects and Applications
- Genetic Syndromes and Imprinting
- Plant Virus Research Studies
- Biological and pharmacological studies of plants
- Pharmacological Effects and Toxicity Studies
- Estrogen and related hormone effects
- Neuroendocrine regulation and behavior
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Epigenetics and DNA Methylation
West Anhui University
2024-2025
Anhui University of Traditional Chinese Medicine
2025
University of Illinois Urbana-Champaign
2020-2024
Abstract Base editors, including dual base are innovative techniques for efficient conversions in genomic DNA. However, the low efficiency of A-to-G conversion at positions proximal to protospacer adjacent motif (PAM) and A/C simultaneous editor hinder their broad applications. In this study, through fusion ABE8e with Rad51 DNA-binding domain, we generate a hyperactive ABE (hyABE) which offers improved editing region (A 10 -A 15 ) PAM, 1.2- 7-fold improvement compared ABE8e. Similarly,...
In humans and mice, loss-of-function mutations in growth hormone-releasing hormone receptor (GHRHR) cause isolated GH deficiency. The mutant GHRHR mouse model, GhrhrLit/Lit (LIT), exhibits loss of serum GH, but also fewer somatotropes. However, how GHRH signaling affects expansion stem progenitor cells giving rise to GH-producing is unknown. LIT mice wild-type littermates were examined for differences proliferation gene expression pituitary lineage markers by quantitative reverse...
Abstract Disclosure: L.T. Raetzman: None. X. Ge: K. Weis: Hypopituitarism results when the pituitary gland is not able to make one or more of its hormones. It estimated that up 80% hypopituitarism detected at near birth has no identifiable cause. We have created a mouse model congenital by conditionally deleting gene Notch2 in developing pituitary. NOTCH2 expressed stem cells and necessary for cell maintenance, proliferation, differentiation. However, pathways engages affect development...
Abstract Wuzi Yanzong decoction (WZYZD) belongs to the traditional formula for treating male infertility caused by oligoasthenozoospermia (OLI). This research aims elucidate therapeutic substance basis and potential pharmacological mechanisms of WZYZD in OLI. A total 52 chemical ingredients were identified from WZYZD. HE TUNEL staining demonstrated that can markedly alleviate Immunofluorescence analysis showed significantly increase expression levels DNMT3 A, PIWIL1, SETDB1, PRMT5. Methyl...
Abstract There is a pressing need today to mechanistically interpret sets of genomic variants associated with diseases. Here we present tool called ‘VarSAn’ that uses network analysis algorithm identify pathways relevant given set variants. VarSAn analyzes configurable whose nodes represent variants, genes and pathways, using Random Walk Restarts rank for relevance the reports P-values pathway relevance. It treats non-coding coding differently, properly accounts number impacted by each...
Abstract Clinical evidence indicates that patients with temporal lobe epilepsy (TLE) often show differential outcomes of comorbid conditions in relation to the lateralization seizure focus. A particularly strong relationship exists between side focus and propensity for distinct reproductive endocrine comorbidities women TLE. Therefore, here we evaluated whether targeting left or right dorsal hippocampus intrahippocampal kainic acid (IHKA) injection, a model TLE, produces different...
ABSTRACT There is a pressing need today to mechanistically interpret sets of genomic variants associated with diseases. Here we present tool called ‘VarSAn’ that uses network analysis algorithm identify pathways relevant given set variants. VarSAn analyzes configurable whose nodes represent variants, genes and pathways, using Random Walk Restarts rank for relevance the reports p-values pathway relevance. It treats non-coding coding differently, properly accounts number impacted by each...
Abstract Phthalates are chemicals used in various common products including plastics and medical devices, leading to widespread contact. Phthalate exposure during embryonic development can cause changes puberty timing, reduced fertility genital abnormalities. Previous studies on prenatal Di-(2-ethylhexyl) phthalate (DEHP) mice indicated that it disrupts pituitary-gonadal feedback alters reproductive performance the offspring, however, mechanism behind this is unknown. We hypothesize DEHP a...