A5100331711- Metal-Organic Frameworks: Synthesis and Applications
- CRISPR and Genetic Engineering
- Magnetism in coordination complexes
- Health Literacy and Information Accessibility
- Crystal structures of chemical compounds
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- Misinformation and Its Impacts
- Dermatological and Skeletal Disorders
- Heterotopic Ossification and Related Conditions
- COVID-19 and Mental Health
- Virus-based gene therapy research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
East China Normal University
2017-2024
Green Chemistry
2018
Abstract Base editors, including dual base are innovative techniques for efficient conversions in genomic DNA. However, the low efficiency of A-to-G conversion at positions proximal to protospacer adjacent motif (PAM) and A/C simultaneous editor hinder their broad applications. In this study, through fusion ABE8e with Rad51 DNA-binding domain, we generate a hyperactive ABE (hyABE) which offers improved editing region (A 10 -A 15 ) PAM, 1.2- 7-fold improvement compared ABE8e. Similarly,...
Pseudoxanthoma elasticum (PXE), caused by ABCC6/MRP6 mutation, is a heritable multisystem disorder in humans. The progressive clinical manifestations of PXE are accompanied ectopic mineralization various connective tissues. However, the pathomechanisms underlying remains obscure, and effective treatment currently available. In this study, we generated zebrafish abcc6a mutants using transcription activator-like effector nuclease (TALEN) technique. young adult zebrafish, expressed eyes, heart,...
Five novel amino acid-modified HCPs have been prepared using the V-shaped semi-rigid 4,4′-oxybis(benzoic acid) instead of usual rigid polycarboxylate units.
Five novel homochiral metal–organic frameworks (HMOFs) have been synthesized using a semirigid alanine-derived ligand and varied auxiliary N-donor ligands, namely, [Cu2(TMAla)2(bipy)2]·10H2O (1) [Cu(TMAla)(bpea)0.5(H2O)]·H2O (2), Ln(TMAla)(HTMAla)(phen) (Ln = Eu, 3; Tb, 4; Gd, 5), where H2TMAla terephthaloyl-mono(l-alanine), bipy 4,4′-bipyridine, bpea 1,2-bis(4-pyridyl)ethane, phen 1,10-phenanthroline. Crystallographic analysis indicates that all the complexes contain left- and/or...
Improving citizen epidemic prevention information literacy is one of the most cost-efficient and important measures to improve people’s abilities effectively deal with future public health crises. Epidemic beneficial individuals’ ability crises in future. By summarizing related domestic international research, utilizing an empirical methodology, we constructed assessment model good reliability, validity, fit. The composed four indicators: (1) “epidemic awareness”; (2) knowledge”; (3)...