A5100717737- RNA Research and Splicing
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Phytochemistry and biological activity of medicinal plants
- Adipose Tissue and Metabolism
- Cancer-related gene regulation
- Regulation of Appetite and Obesity
- Spine and Intervertebral Disc Pathology
- Research in Cotton Cultivation
- Genetic factors in colorectal cancer
- Congenital heart defects research
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Biochemical Analysis and Sensing Techniques
- Epigenetics and DNA Methylation
- Biochemical effects in animals
- Cell death mechanisms and regulation
- FOXO transcription factor regulation
- Endoplasmic Reticulum Stress and Disease
- Connective Tissue Growth Factor Research
- Biomarkers in Disease Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Hedgehog Signaling Pathway Studies
Jiamusi University
2023
Peking Union Medical College Hospital
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2023
Osaka City University
2019-2021
Shanxi University
2018-2021
Qingdao Municipal Hospital
2019
Qingdao University
2019
Yunnan Academy of Agricultural Sciences
2019
Jinan University
2018
Harbin Medical University
2014-2017
Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis.
Significance Tumor suppressor genes (TSGs) play important roles in lung cancer initiation, progression, and even metastasis. Here, we take advantage of the clustered regularly interspaced short palindromic repeats/Cas9-mediated screening vivo technique to identify multiple tumor contributing malignant progression. Using genetically engineered mouse models, further confirm tumor-suppressive role epigenetic regulator UTX provide therapeutic implications for UTX-deficient tumors. Thus, our work...
Licochalcone A (LCA), a licorice chalconoid, is considered to be bioactive agent with chemopreventive potential. This study investigated the mechanisms involved in LCA-induced apoptosis human bladder cancer T24 cells. LCA significantly inhibited cells proliferation, increased reactive oxygen species (ROS) levels, and caused apoptosis. Moreover, induced mitochondrial dysfunction, caspase-3 activation, poly-ADP-ribose polymerase (PARP) cleavage, which displayed features of...
Osteosarcoma is a prevalent type of cancer and has high metastatic ability, particularly for metastasis to the lungs. Effective treatment strategies have improved, however, detailed molecular mechanism underlying onset this malignancy remains be fully elucidated. The current study investigated role tripartite motif (TRIM) family protein TRIM59 in osteosarcoma growth metastasis. It was identified that overexpressed clinical tissues cultured cell lines. In addition, MTT assay demonstrated U2OS...
Flavonoids are important components of 'functional foods', with beneficial effects on cardiovascular function. The present study was designed to investigate whether licochalcone D (LD) could be a cardioprotective agent in ischemia/reperfusion (I/R) injury and shed light its possible mechanism. Compared the I/R group, LD treatment enhanced myocardial function (increased LVDP, dp/dtmax, dp/dtmin, HR CR) suppressed cardiac (decreased LDH, CK infarct size). Moreover, reversed I/R-induced...
Hydrogen peroxide (H2O2) induces oxidative injury to human osteoblasts. The expression and potential function of circular RNA HIPK3 (circHIPK3) in H2O2-treated osteoblasts were tested. We show that H2O2 significantly downregulated circHIPK3 OB-6 cells primary Furthermore, levels decreased the necrotic femoral head tissues dexamethasone-treated patients. In osteoblastic osteoblasts, forced overexpression by a lentiviral construct alleviated H2O2-induced viability reduction, cell death...
The aim of this study was to determine the relationship between proliferation inhibition and production reactive oxygen species (ROS) induced by Licochalcone A (LCA). Cell viability evaluated using sulforhodamine B (SRB) assay. Intracellul
Land surface temperatures (LSTs) at high-spatial resolution are significant for hydrological, meteorological, and ecological studies. An alternative method to obtain LSTs a is downscale from coarse finer resolution. In this article, we propose new algorithm based on temperature vegetation dryness index in combination with elevation correction Moderate Resolution Imaging Spectroradiometer LST data 1000 m 90 m. The performance of the was assessed using Advanced Spaceborne Thermal Emission...
This study investigated the mechanisms by which licochalcone B (LCB) inhibits adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine (SRB) assay. migration invasion ability were conducted wound-healing assay matrigel transwell The activities matrix metalloproteinases (MMP)-2 MMP-9 measured gelatin zymography protease assays. expression in protein level NF-κBP65 AP-1 determined ELISA method; levels MMP-9, NF-κBP65,...
Oral squamous cell carcinoma (OSCC) invades surrounding tissues by upregulating matrix metalloproteinases (MMPs) -2 and −9, which causes over-expression of the Hedgehog signaling proteins Shh Gli-1 degradation extracellular matrix, thereby creating a "highway" for tumor invasion. We explored potential low intensity ultrasound (LIUS) doxorubicin (DOX) to inhibit formation this "highway". MTT assays were used examine OSCC viability after exposure LIUS DOX. The morphological changes...
The current study investigated the mechanisms by which licochalcone C induces apoptosis of T24 human malignant bladder cancer cells. Cell viability was evaluated using an MTT assay. Apoptosis a morphological assay, flow cytometry and caspase‑3 activity Alterations in gene expression levels Bcl‑2 family members were measured semi‑quantitative reverse transcription‑polymerase chain reaction assays. protein pro‑caspase‑3 cleaved poly(ADP ribose) polymerase western blotting. results indicated...
Objective To evaluate the clinical outcome of reoperation after percutaneous endoscopic lumbar discectomy (PELD) as compared with primary spinal decompression and fusion. Methods A retrospective study from December 2014 to 2017 was conducted at Peking Union Medical College Hospital comprised 39 patients symptomatic degenerative disease (LDD): 13 post‐PELD who underwent (revision surgery group) 26 received fusion (primary open group). The two groups were regarding: operative time, blood loss,...