Wei‐Sheng Chen

ORCID: 0000-0001-8672-180X
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About
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Research Areas
  • Extraction and Separation Processes
  • Recycling and Waste Management Techniques
  • Systemic Lupus Erythematosus Research
  • Galectins and Cancer Biology
  • Metal Extraction and Bioleaching
  • Spondyloarthritis Studies and Treatments
  • Rheumatoid Arthritis Research and Therapies
  • Thyroid and Parathyroid Surgery
  • Salivary Gland Disorders and Functions
  • Connective tissue disorders research
  • Neuroendocrine Tumor Research Advances
  • Esophageal and GI Pathology
  • Thyroid Cancer Diagnosis and Treatment
  • Colorectal Cancer Surgical Treatments
  • Neurotransmitter Receptor Influence on Behavior
  • Psoriasis: Treatment and Pathogenesis
  • Ionosphere and magnetosphere dynamics
  • Gastric Cancer Management and Outcomes
  • Minerals Flotation and Separation Techniques
  • Congenital heart defects research
  • Sympathectomy and Hyperhidrosis Treatments
  • Advancements in Battery Materials
  • Photovoltaic Systems and Sustainability
  • Lung Cancer Diagnosis and Treatment
  • Neuroscience and Neuropharmacology Research

Nanfang Hospital
2018-2025

Southern Medical University
2006-2025

Fujian Medical University
2013-2025

Fujian Provincial Cancer Hospital
2019-2025

First Affiliated Hospital of Jinan University
2025

Taipei Veterans General Hospital
2015-2024

Ningbo University
2011-2024

National Yang Ming Chiao Tung University
2015-2024

National Cheng Kung University
2015-2024

Ningbo Kangning Hospital
2021-2024

Abstract Despite the ever-increasing output of Illumina sequencing data, loci with extreme base compositions are often under-represented or absent. To evaluate sources base-composition bias, we traced genomic sequences ranging from 6% to 90% GC through process by quantitative PCR. We identified PCR during library preparation as a principal source bias and optimized conditions. Our improved protocol significantly reduces amplification minimizes previously severe effects instrument temperature...

10.1186/gb-2011-12-2-r18 article EN cc-by Genome biology 2011-02-21

The paper focuses on the improved process of metal recovery from lithium-ion batteries (LIBs) lithium nickel manganese cobalt oxide (NMC) cathode waste materials by using hydrometallurgical methods. In acid leaching step, essential effects acidity concentration, H2O2 time, liquid-solid mass ratio, and reaction temperature with percentage were investigated in detail. material was leached 2M H2SO4 10 vol. % at 70 °C 300 rpm a ratio 30 mL/g. order to complete process, this designs proper...

10.3390/met8050321 article EN cc-by Metals 2018-05-06

Lymph node status is the primary determinant in treatment decision making early gastric cancer (EGC). Current evaluation methods are not adequate for estimating lymph metastasis (LNM) EGC.To develop and validate a prediction model based on fully quantitative collagen signature tumor microenvironment to estimate individual risk of LNM EGC.This retrospective study was conducted from August 1, 2016, May 10, 2018, at 2 medical centers China (Nanfang Hospital Fujian Provincial Hospital)....

10.1001/jamasurg.2018.5249 article EN JAMA Surgery 2019-01-30

Background Aldosterone levels correlate with the incidence of myocardial infarction and mortality in cardiovascular patients. promotes atherosclerosis animal models, but mechanisms are poorly understood. Methods Results was infused to achieve pathologically relevant that did not increase blood pressure atherosclerosis‐prone apolipoprotein E–knockout mouse (ApoE−/−). increased aortic root 1.8±0.1‐fold after 4 weeks arch 3.7±0.2‐fold 8 weeks, without significantly affecting plaque size...

10.1161/jaha.112.000018 article EN cc-by-nc-nd Journal of the American Heart Association 2013-01-23

Abstract Lymphangiogenesis plays a pivotal role in diverse pathological conditions. Here, we demonstrate that carbohydrate-binding protein, galectin-8, promotes lymphangiogenesis. Galectin-8 is markedly upregulated inflamed human and mouse corneas, galectin-8 inhibitors reduce inflammatory In the model of corneal allogeneic transplantation, galectin-8-induced lymphangiogenesis associated with an increased rate graft rejection. Further, murine herpes simplex virus keratitis, pathology are...

10.1038/ncomms11302 article EN cc-by Nature Communications 2016-04-12

Because of increasing environmental awareness, it is becoming more important to remove harmful elements from water solutions. This study used activated carbon (AC) derived waste wood-based panels as the base material, oxidized with nitric acid (OAC), and grafted iminodiacetic (IDA-OAC) improve adsorption capacity affinity for metals. The characterization AC, OAC, IDA-OAC was conducted via FTIR, SEM, N2 desorption analysis, elemental Boehm titration, point zero charge (PZC). instrument...

10.3390/pr10010150 article EN Processes 2022-01-12

Abstract Aims/Introduction Gastric cancer, one of the most common malignant tumors worldwide, is affected by insulin resistance. The triglyceride glucose (TYG) index considered a surrogate indicator resistance; however, its prognostic value in patients with gastric cancer remains obscure. This study aimed to determine whether TYG could predict long‐term prognosis after radical resection gastrectomy. Materials and Methods We retrospectively analyzed who underwent preoperative was calculated...

10.1002/cam4.6837 article EN cc-by Cancer Medicine 2024-01-11

Abstract The bonding and crystalline structures of oil‐fried fly ash collected from a power plant were analyzed by using Raman spectroscopy X‐ray diffraction (XRD), respectively. These carbon powders underwent series annealing treatment for graphitization crystallization. In spectra, the refined, unburned contains clearly D, G D′ peaks under 2000 or 2700 °C treatment. spectral line shape heated at is similar to that commercial graphite made process. XRD (002), (100) (004) heating °C. bar....

10.1002/jrs.2532 article EN Journal of Raman Spectroscopy 2009-11-20

The mouse protocadherin (Pcdh) -α, -β, and -γ gene clusters encode more than 50 protein isoforms, the combinatorial expression of which generates vast single-cell diversity in brain. At present, mechanisms by this is expressed are not understood. Here we show that two transcriptional enhancer elements, HS5-1 HS7, play a critical role Pcdhα mice. We element functions as an neurons silencer nonneuronal cells. activity correlates with binding zinc finger DNA CTCF to target promoters, requires...

10.1073/pnas.1114357108 article EN Proceedings of the National Academy of Sciences 2011-09-26

Systemic lupus erythematosus (SLE) is a prototype of systemic autoimmune disease in which cytokines such as B lymphocyte chemoattractant (BLC, or CXC motif ligand 13, CXCL13) may play important roles pathogenesis. We investigated the implications CXCL13 SLE and nephritis.Serum samples from 425 patients with 106 healthy control individuals were analyzed for concentration by ELISA. Tissue expression its corresponding receptor CXCR5 observed kidney. The CXCR5-bearing cells flow cytometry.Serum...

10.3899/jrheum.090450 article EN The Journal of Rheumatology 2009-12-01

Background: Ankylosing spondylitis (AS) is a chronic arthritis with pathogenesis which not fully understood. A third subset of IL-17-producing T helper cells, called Th17 has been discovered and characterized. We investigated whether IL-17 IL-23, two Th17-related cytokines, play any roles in the of, have correlations with, disease activity clinical manifestations AS. Methods: This cross-sectional study included 49 AS patients 25 healthy control subjects. The serum IL-23 levels were measured...

10.1016/j.jcma.2012.05.006 article EN publisher-specific-oa Journal of the Chinese Medical Association 2012-07-01

The capability of using silver nanoparticle based near-infrared surface enhanced Raman scattering (SERS) spectroscopy combined with principal component analysis (PCA) and linear discriminate (LDA) to differentiate esophageal cancer tissue from normal was presented. Significant differences in intensities prominent SERS bands were observed between tissues. PCA-LDA multivariate the measured spectra achieved diagnostic sensitivity 90.9% specificity 97.8%. This exploratory study demonstrated...

10.1063/1.4789996 article EN Applied Physics Letters 2013-01-28

AMP-activated protein kinase (AMPK) is a central metabolic sensor and plays an important role in regulating glucose, lipid cholesterol metabolism. Therefore, AMPK key therapeutic target diabetes. Recent pilot studies have suggested that diabetes drugs may reduce the risk of cancer by affecting pathway. However, association between proliferation hepatocellular carcinoma (HCC) unknown. In this study, we investigated relationship activity HCC cell lines, nude mice human clinic samples. We first...

10.1371/journal.pone.0093256 article EN cc-by PLoS ONE 2014-04-07
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