A5041228529- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Eating Disorders and Behaviors
- Nutritional Studies and Diet
- Stress Responses and Cortisol
- Electrolyte and hormonal disorders
- Agriculture Sustainability and Environmental Impact
- Adrenal Hormones and Disorders
- Exercise and Physiological Responses
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Muscle Physiology and Disorders
- Lipid metabolism and biosynthesis
- Obesity and Health Practices
- Apelin-related biomedical research
- Behavioral Health and Interventions
- Eicosanoids and Hypertension Pharmacology
- Phytase and its Applications
- Estrogen and related hormone effects
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2025
Vita-Salute San Raffaele University
2010-2025
San Raffaele University of Rome
2020-2024
IRCCS Ospedale San Raffaele
2009-2023
The Open University
2022
CTO Andrea Alesini
2010
National Research Council
2009
University of Siena
2006
Introduction Food preferences are influenced by various factors, such as culture, age, and gender. The relationship between food tastes, meal preferences, eating habits has been studied extensively in recent years; however, research on gender differences these fields still needs to be addressed. aim of this study was investigate through self-administered questionnaires a large Italian population sample. Methods online survey included questions habits, sport involvement. Results results the...
Background: Gender differences in metabolic response to lifestyle interventions remain poorly explored. This study aimed evaluate the impact of a six-month Mediterranean diet (MD) intervention combined with regular physical activity on parameters overweight adults. Methods: A prospective cohort was conducted an obesity clinic Rome, Italy, involving adults (BMI ≥ 25 kg/m2) motivated improve their lifestyle. Participants (n = 205; 107 men and 98 women) self-selected into groups (aerobic,...
The mineralocorticoid receptor (MR) controls adipocyte function, but its role in the conversion of white adipose tissue (WAT) into thermogenic fat has not been elucidated. We investigated responses to MR antagonists spironolactone (spiro; 20 mg/kg/d) and drospirenone (DRSP; 6 C57BL/6 mice fed a high-fat (HF) diet for 90 d. DRSP spiro curbed HF diet-induced impairment glucose tolerance, prevented body weight gain expansion. Notably, either antagonist induced up-regulation brown...
Background Aldosterone levels correlate with the incidence of myocardial infarction and mortality in cardiovascular patients. promotes atherosclerosis animal models, but mechanisms are poorly understood. Methods Results was infused to achieve pathologically relevant that did not increase blood pressure atherosclerosis‐prone apolipoprotein E–knockout mouse (ApoE−/−). increased aortic root 1.8±0.1‐fold after 4 weeks arch 3.7±0.2‐fold 8 weeks, without significantly affecting plaque size...
Introduction This study investigates the interplay between body composition, dietary patterns, and physical activity across genders, focusing on gender-specific differences in food preferences eating behaviors. Understanding these interactions is crucial for developing targeted nutritional lifestyle interventions. Methods A cross-sectional was conducted with 1,333 participants (58.7% female, 41.3% male), aged 18–65 years. Participants were categorized into tertiles based their fat mass to...
Mineralocorticoid receptor antagonists (MRAs) are recommended for the treatment of heart failure and hypertension, mainly due to their natriuretic anti-fibrotic mode action. Rodent studies have shown that MRAs can prevent adverse metabolic consequences obesity but an elucidation underlying molecular mechanisms is missing. Here, we investigated effects novel non-steroidal MRA finerenone (FIN) in a mouse model high-fat diet (HFD)-induced signaling pathways activated by MR antagonism at level...
This cross-sectional study analyses differences in dietary habits, taste preferences, variety of protein sources and body composition (BC) profiles among individuals following omnivorous, flexitarian, lacto-ovo-vegetarian pescatarian diets. Furthermore, it assesses the correlations between these patterns various sports, classified by exercise intensity, relation to BC parameters. The analysed eating habits data 1342 participants aged 18–65 years, into four diet groups based on their 7-day...
Migraine is the second world's cause of disability. Among non-pharmacological treatments, nutritional intervention, particularly ketogenic diet, represents one most promising approaches.This a prospective, single center, randomized, controlled study aimed at evaluating efficacy very low-calorie diet (VLCKD) compared to hypocaloric balanced (HBD) in migraine prophylaxis patients affected by high-frequency episodic (HFEM) with Body Mass Index (BMI) > 27 kg/m2. Fifty-seven were randomly...
Gender differences in dietary patterns and physical activity are known to influence metabolic health, but research exploring these using principal component analysis (PCA) is limited. This study aims identify distinct of eating behaviour, body composition between men women, order develop tailored interventions. A cross-sectional was conducted on 2,509 adults attending a health centre. Data habits, were collected by means questionnaires bioimpedance analysis. PCA used behaviour activity....
Gender differences in dietary habits, physical activity and body composition are key determinants of health disease risk. Although these well documented, their variation across age groups remains poorly explored. This study examines gender-specific patterns eating behaviours, sport preferences metrics, with the aim providing evidence for tailored public interventions. A cross-sectional was conducted on 2,276 participants (1,349 females 927 males) aged 18–75 years. Recruitment combined an...
Obesity is a major global health problem and contributes to increased morbidity mortality through its association with metabolic disorders, cardiovascular disease other chronic pathological conditions [...]
Brown adipose tissue (BAT) activity plays a key role in regulating systemic energy. The activation of BAT results increased energy expenditure, making this an attractive pharmacological target for therapies against obesity and type 2 diabetes. Sirtuin 5 (SIRT5) affects function by adipogenic transcription factor expression mitochondrial respiration. We analyzed the SIRT5 different depots mice. treated 3T3-L1 preadipocytes mouse primary preadipocyte cultures with inhibitor MC3482 investigated...