A5074163476- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Diet and metabolism studies
- Botulinum Toxin and Related Neurological Disorders
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Frailty in Older Adults
- Nutrition and Health in Aging
- Celiac Disease Research and Management
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Diet, Metabolism, and Disease
- Dysphagia Assessment and Management
- Gastrointestinal disorders and treatments
- Nicotinic Acetylcholine Receptors Study
- Autism Spectrum Disorder Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genetics, Aging, and Longevity in Model Organisms
- Stuttering Research and Treatment
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2018-2025
IRCCS Ospedale San Raffaele
2023-2025
San Raffaele University of Rome
2022-2024
Vita-Salute San Raffaele University
2021-2024
University of Parma
2023
Istituto delle Scienze Neurologiche di Bologna
2023
University Hospital of Lausanne
2004-2007
Uppsala University Hospital
2003
In Brief Atelectasis caused by general anesthesia is increased in morbidly obese patients. We have shown that application of positive end-expiratory pressure (PEEP) during the induction prevents atelectasis formation nonobese therefore studied efficacy PEEP patients to prevent atelectasis. Twenty-three adult (body mass index >35 kg/m2) were randomly assigned one two groups. group, breathed 100% oxygen (5 min) with a continuous airway 10 cm H2O and, after induction, mechanical ventilation via...
In Brief General anesthesia promotes atelectasis formation, which is augmented by administration of large oxygen concentrations. We studied the efficacy positive end-expiratory pressure (PEEP) application during induction general (fraction inspired [Fio2] 1.0) to prevent atelectasis. Sixteen adult patients were randomly assigned one two groups. Both groups breathed 100% O2 for 5 min and, after a induction, mechanical ventilation via face mask with Fio2 1.0 another before endotracheal...
Abstract Background and objectives The identification of predictors response to antiCGRP mAbs could favor tailored therapies personalized treatment plans. This study is aimed at investigating ≥ 50%, 75% 100% 24 weeks in patients with high-frequency episodic (HFEM: 8–14 days/month) or chronic migraine (CM). Methods a large, multicenter, cohort, real-life study. We considered all consecutive adult affected by HFEM CM who were prescribed for 20 headache centers. Patients interviewed...
Fremanezumab has demonstrated to be effective, safe, and tolerated in the prevention of episodic or chronic migraine (CM) randomized, placebo-controlled trials (RCTs). Real-life studies are needed explore drug effects unselected patients routine circumstances provide higher generalizability results. This study explores effectiveness, safety, tolerability fremanezumab a real-life population individuals affected by high-frequency (HFEM: 8-14 days/month) CM.This is 12-week multicenter,...
To assess the frequency and characteristics of late responders (>12 weeks) to monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP).
To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥ 8 days/month) or chronic (CM: 15 days/month), multiple preventive treatment failures.This is a prospective, cohort, study at 28 headache centers on consecutive affected by HFEM CM failures who were prescribed subcutaneous (225 mg monthly/675 quarterly) for 24 weeks. Primary endpoint was change monthly days (MMDs) (MHDs) weeks 21-24 compared...
Abstract Objective Nearly 60% of migraine patients treated with monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway experience a ≥ 50% reduction in monthly days (MMD) at 12 weeks compared to baseline (responders) . However, approximately half not responding anti-CGRP mAbs ≤ do respond 24 ( late responders) We assessed frequency and characteristics only > ultra-late responders ). Methods In this multicenter n = 16), prospective, observational,...
Abstract Objectives While a single 12-month treatment cycle (TrC) with anti-CGRP mAbs is not disease-modifying for most patients, there limited understanding of the effects multiple TrCs on migraine course. We evaluated whether second TrC might modify course by comparing occurrence relapse after discontinuation to that following cessation first TrC. Methods In real-life, multicenter, prospective study we considered all consecutive patients diagnosed high-frequency episodic (HFEM) or chronic...
Celiac disease (CD) has a high prevalence but remains largely underdiagnosed. Although extensive studies have confirmed that children with CD do not an increased risk of severe COVID-19, public health regulations associated the SARS-CoV-2 pandemic may exacerbated this problem. The aim study was to assess effect on number new-onset cases. Additionally, role in autoimmune diseases and its influence clinical practice pediatric gastroenterology were briefly reviewed. We described data from...
Migraine is the second world's cause of disability. Among non-pharmacological treatments, nutritional intervention, particularly ketogenic diet, represents one most promising approaches.This a prospective, single center, randomized, controlled study aimed at evaluating efficacy very low-calorie diet (VLCKD) compared to hypocaloric balanced (HBD) in migraine prophylaxis patients affected by high-frequency episodic (HFEM) with Body Mass Index (BMI) > 27 kg/m2. Fifty-seven were randomly...
The implementation of regular prolonged, and effective rehabilitation in people with Parkinson's disease is essential for ensuring a good quality life. However, the continuity care may find barriers related to economic, geographic, social issues. In these scenarios, telerehabilitation could be possible solution guarantee care.
Long-term (1-year) fremanezumab treatment proved to be effective, safe, and well tolerated in individuals with migraine < 2 medication clusters a randomized controlled trial (RCT). We aimed assess real-world evidence (RWE), long-term effectiveness, tolerability, safety of people high-frequency episodic (HFEM) or chronic (CM) > 3 failures various comorbidities. A 48-week, prospective, multicenter (n = 26), cohort study assessed fremanezumab's safety, tolerability consecutive adults HFEM CM...
Background: Hypokinetic dysarthria is a speech disorder observed in almost 90% of PD patients that can appear at any stage the disease, usually worsening as disease progresses. Today, therapy intervention seen possible therapeutic option to alleviate and slow down progression symptoms. This study aims investigate validity traditional with aim improving quality life patients, by comparing subjective clinical assessment objective instrumental measures (IOPI voice analysis). Methods: an...
Micronuclei (MN) are cellular structures containing chromosome fragments or whole chromosomes that fail to be incorporated into the main nuclei during mitosis. MN measured in lymphocytes using cytokinesis-block method and buccal cells among most widely used methods for measuring DNA damage humans. However, it remains unclear whether they correlate well with each other. This has important implications regarding existing evidence linking prospective cancer risk can also extended cells, a much...
Abstract The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), and especially its complications is still not fully understood. In fact, a very high number patients with COVID-19 die because thromboembolic causes. A role plasminogen, as precursor fibrinolysis, has been hypothesized. this study, we aimed to investigate the association between plasminogen levels COVID-19-related outcomes in population 55 infected Caucasian (mean...
Cigarette smoking is a primary contributor to mortality risks and associated with various diseases. Among these, COPD represents significant global disability. The objective of this study investigate the effect on selected battery variables, an emphasis DNA damage. A total 87 elderly patients diagnosed COPD, divided into three groups based their history (current, former, never-smokers), were evaluated using cross-sectional approach. Clinical features including inflammatory/oxidative...
Background The prevalence of sarcopenic obesity (SO) is increasing worldwide, posing important challenges to public health and national care system, especially during the COVID pandemic. In subjects with SO, it essential reduce body weight, preserve lean mass, avoid worsening muscle function. Adequate nutrition correct physical activity counteract SO progression. Very Low Calorie Ketogenic Diet (VLCKD), a well-established nutritional intervention for obesity, has been also indicated...
Jejunal diverticulosis is a rare entity with variable clinical and anatomical presentations. Its reported incidence varies from 0.05% to 6%. Although there no consensus on the management of asymptomatic jejunal diverticular disease, some complications are potentially life threatening require early surgical treatment. We report case an 88-year-old man investigated for acute abdominal pain high biological inflammatory syndrome. Inflammation multiple giant diverticulum was discovered at...