A5070276772- Pancreatic function and diabetes
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Diabetes Management and Research
- Redox biology and oxidative stress
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Nuclear Receptors and Signaling
- Cardiovascular Disease and Adiposity
- Ion Transport and Channel Regulation
- Metabolism, Diabetes, and Cancer
- Muscle Physiology and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Laser Applications in Dentistry and Medicine
- Liver Disease Diagnosis and Treatment
- Muscle metabolism and nutrition
- COVID-19 Clinical Research Studies
- Mitochondrial Function and Pathology
- Telomeres, Telomerase, and Senescence
- Diet and metabolism studies
- Biochemical effects in animals
- Diabetes Treatment and Management
San Raffaele University of Rome
2023-2025
University of Rome Tor Vergata
2016-2025
The Open University
2024
University of Miami
2016-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Creative Commons
2022
Enhanced oxidative stress contributes to the pathogenesis of diabetes and its complications. Peroxiredoxin 6 (PRDX6) is a key regulator cellular redox balance, with peculiar ability neutralize peroxides, peroxynitrite, phospholipid hydroperoxides. In current study, we aimed define role PRDX6 in pathophysiology type 2 (T2D) using knockout (-/-) mice. Glucose insulin responses were evaluated respectively by intraperitoneal glucose tolerance tests. Peripheral sensitivity was analyzed...
Dietary consumption of olive oil represents a key pillar the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as prevention chronic non-communicable diseases like cancers and neurodegenerative diseases, among others. These health benefits are partly mediated by high-quality extra virgin (EVOO), is produced mostly in countries directly made from olives, fruit tree (Olea europaea L.). Preclinical evidence supports existence antioxidant...
Abstract The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), and especially its complications is still not fully understood. In fact, a very high number patients with COVID-19 die because thromboembolic causes. A role plasminogen, as precursor fibrinolysis, has been hypothesized. this study, we aimed to investigate the association between plasminogen levels COVID-19-related outcomes in population 55 infected Caucasian (mean...
Insulin action and often glucose-stimulated insulin secretion are reduced in obesity. In addition, the excessive intake of lipids increases oxidative stress leading to overt type 2 diabetes mellitus (T2DM). Among antioxidative defense systems, peroxiredoxin 6 (PRDX6) is able reduce H2O2 short chain phospholipid hydroperoxides. Increasing evidences suggest that PRDX6 involved pathogenesis atherosclerosis T2DM, but its role etiopathology obesity complications still not known. Therefore,...
Polyphenols have been widely studied for their antiviral effect against respiratory virus infections. Among these, resveratrol (RV) has demonstrated to inhibit influenza replication and more recently, it tested together with pterostilbene severe acute syndrome coronavirus 2 (SARS-CoV-2) infection. In the present work, we evaluated activity of polydatin, an RV precursor, a mixture polyphenols other micronutrients, named A5+, SARS-CoV-2 To this end, infected Vero E6 cells analyzed both viruses...
The aim of this study was to assess the impact glucose control, diabetes-related complications and cardiometabolic risk factors on diabetic foot ulcers (DFUs) DFU in Albanian adult inpatients with T2D.We conducted a retrospective case-control 482 T2D. defined as full-thickness skin lesion requiring ≥14 days for healing classified at time hospital admission. Demographic biochemical parameters participants, presence comorbidities admission were evaluated through chart review.Mean age...
Background: Obesity is a pandemic disease characterized by excessive severe body comorbidities. Reduction in fat accumulation represents mechanism of prevention, and the replacement white adipose tissue (WAT) with brown (BAT) has been proposed as one promising strategy against obesity. In present study, we sought to investigate ability natural mixture polyphenols micronutrients (A5+) counteract adipogenesis promoting WAT browning. Methods: For this employed murine 3T3-L1 fibroblast cell line...
With the increase in average life expectancy, several individuals are affected by age-associated non-communicable chronic diseases (NCDs). The presence of NCDs, such as type 2 diabetes mellitus (T2DM), leads to reduction skeletal muscle mass, a pathological condition defined sarcopenia. A key factor linking sarcopenia with cellular senescence and (DM) is oxidative stress. We previously reported absence Peroxiredoxin 6 (Prdx6), an antioxidant enzyme implicated maintaining intracellular redox...
Abstract Ceramide regulates several different cellular responses including mechanisms leading to apoptosis. Serum- and glucocorticoid-inducible protein kinase (SGK)-1 is a serine threonine kinase, which activates survival pathways in response stress stimuli. Recently, we demonstrated an anti-apoptotic role of SGK-1 human umbilical endothelial cells treated with high glucose. In the present study, since ceramide induces apoptosis by multiple diabetes its complication such as nephropathy,...
Type 1 diabetes (T1D) represents an autoimmune disease caused by the gradual immune-mediated destruction of insulin-producing beta cells within pancreatic islets Langerhans, resulting in lifelong need for exogenous insulin therapy. According to recent estimates, T1D currently affects about 8.4 million individuals worldwide. Since a definitive biological cure this is not available yet, there great novel therapeutic strategies aimed at safely and effectively altering natural history during its...
Parkinson's disease (PD) is second-most common disabling neurological disorder worldwide, and unfortunately, there not yet a definitive way to prevent it. Polyphenols have been widely shown protective efficacy against various PD symptoms. However, data on their effect physio-pathological mechanisms underlying this are still lacking. In the present work, we evaluated activity of mixture polyphenols micronutrients, named A5+, in murine neuroblastoma cell line N1E115 treated with...
Tyrosol (TR), a major polyphenol found in extra virgin olive oil (EVOO), exerts several antioxidant effects. However, only scarce evidences are present regarding its activity on adipocytes and obesity. This study evaluated the role of TR adipogenesis. Murine 3T3-L1 preadipocytes were incubated with (300 500 μM), administration inhibited adipogenesis by downregulation adipogenic factors (leptin aP2) transcription (C/EBPα, PPARγ, SREBP1c, Glut4) modulation histone deacetylase sirtuin 1. After...
Several studies reported the association between Huntington Disease (HD), an autosomal dominant disorder due to accumulation of mutated Huntingtin (HTT), and Diabetes Mellitus (DM). Moreover, it is well established as diabetic patients are more prone develop neurodegeneration cognitive decline. In a study conducted on mice, we demonstrated HTT played central role metabolic regulator, highlighting pathological loop DM HD. Furthermore, has also been described intranasal insulin (Ins)...