A5037357548- Rheumatoid Arthritis Research and Therapies
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Dermatological and COVID-19 studies
- Vitamin D Research Studies
- Psoriasis: Treatment and Pathogenesis
- Glioma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Systemic Lupus Erythematosus Research
- Neuroendocrine Tumor Research Advances
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Thyroid Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Atherosclerosis and Cardiovascular Diseases
- Adenosine and Purinergic Signaling
- Pharmacological Receptor Mechanisms and Effects
- Ocular Diseases and Behçet’s Syndrome
- Vitamin C and Antioxidants Research
- Nosocomial Infections in ICU
Centro Universitário de Várzea Grande
2018-2025
Universidade Federal de São Paulo
2014-2024
Universidade Estadual de Campinas (UNICAMP)
2024
Universidade Federal do Sul e Sudeste do Pará
2024
University of Rome Tor Vergata
2023
Institute of Infection and Immunity
2023
Saint Camillus International University of Health and Medical Sciences
2023
Hospital São Paulo
2023
University of Miami
2023
Anhanguera-Uniderp University
2017-2021
A dysregulated immune response characterized by the hyperproduction of several pro-inflammatory cytokines (a.k.a. 'cytokine storm') plays a central role in pathophysiology severe coronavirus disease 2019 (COVID-19) caused acute respiratory syndrome 2 (SARS-CoV-2). In this Perspective article we discuss evidence for synergistic anti-inflammatory and immunomodulatory properties exerted vitamin D dipeptidyl peptidase-4 (DPP-4) inhibitors, latter being class antihyperglycemic agents used...
Objetivo: Relatar o caso de uma paciente acometida por Transtorno Afetivo Bipolar (TAB), internada em um hospital referência psiquiatria. Métodos: Estudo descritivo, restropectivo e longitudinal, foram analisados dados clínicos no setor internação breve do Hospital saúde mental maio 2024. A coleta foi a partir prontuários médicos termo consentimento da seu acompanhante. Resultados Relato Caso: apresentou na surto psicótico, delírios auditivos comportamento agressivo. O tratamento incluiu...
Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by autoimmune destruction of pancreatic beta cells and inadequate insulin production. Remission criteria in T1DM take into account serum levels C-peptide glycosylated hemoglobin, as well the dose administered to patient. However, remission lasting longer than year rare. We describe here cases two young women who presented with positive glutamic acid decarboxylase (GAD) antibody classic clinical manifestations T1DM. Both...
The occurrence of partial remission (honeymoon phase) in type 1 diabetes (T1D) has been associated with a reduced risk chronic microvascular complications diabetes. We have published case reports showing that combination therapy the DPP-4 inhibitor sitagliptin plus vitamin D3 (VIDPP-4i) can prolong honeymoon phase patients new-onset T1D. In present case-control study, we investigated frequency clinical (CR) T1D after VIDPP-4i treatment.In this collected data spanning 10 years from medical...
Leukocytoclastic vasculitis (LCV) is a small vessel involving arterioles, capillaries and postcapillary venules. LCV generally confined to the skin, with extracutaneous manifestations occurring less frequently. has multiple potential etiologies. Indeed, histological can be found in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, immune complex associated systemic diseases (i.e. sarcoidosis, Sjögren's syndrome, rheumatoid arthritis, lupus erythematosus), or cancer,...
Type 1 diabetes (T1D) represents an autoimmune disease caused by the gradual immune-mediated destruction of insulin-producing beta cells within pancreatic islets Langerhans, resulting in lifelong need for exogenous insulin therapy. According to recent estimates, T1D currently affects about 8.4 million individuals worldwide. Since a definitive biological cure this is not available yet, there great novel therapeutic strategies aimed at safely and effectively altering natural history during its...
Aim: To evaluate the performance of four different classification criteria for spondyloarthritis (SpA) in patients with late-onset symptoms and to compare clinical, laboratory radiographic outcomes among before after 45 years age. Patients methods: A total 329 SpA were enrolled this prospective cohort. psoriatic arthritis, reactive colitis associated arthritis peripheral or undifferentiated excluded. The remaining individuals divided into two groups based on their ages at time onset...
Background: The incidence of Type 1 Diabetes Mellitus (T1DM) is on the rise. Since there no curative treatment, it urgent to look for therapies that can delay disease progression and protect pancreatic β-cells. Dipeptidyl peptidase-4 inhibitors (DPP-4i) have shown potential in modulating inflammation preventing β-cell destruction. This protocol describes an upcoming trial evaluate effectiveness DPP-4i alogliptin delaying stage 2 (presymptomatic) 3 (symptomatic) T1DM. Patients Methods: We...
Mononeuritis multiplex (MM) is an unusual form of peripheral neuropathy involving at least two noncontiguous nerve trunks. The pure sensory MM occurs rarely. Immunoglobulin (Ig)G subclass deficiency a clinically and genetically heterogeneous disorder. Up to 50% adults with selective subnormal IgG1 levels or have concomitant autoimmune Herein, we report the case patient who showed remarkable clinical improvement after 2-year combination therapy DPP-4 inhibitor sitagliptin plus vitamin D3.
In recent decades, obesity has become a public health problem in many countries. The objective of this study was to evaluate the main joint and extra-articular manifestations related spondyloarthritis (SpA) after bariatric surgery (BS) retrospective cohort.Demographic, clinical, laboratory imaging data from nine patients whose SpA symptoms started BS have been described. Modified New York (mNY) criteria for ankylosing spondylitis (AS) Assessment Spondyloarthritis International Society (ASAS)...
Poucos estudos avaliaram o perfil do uso de drogas modificadoras doença (DMD) em pacientes brasileiros com diagnóstico espondiloartrite (EpA). Um protocolo comum investigação foi prospectivamente aplicado 1505 classificados como EpA pelos critérios Grupo Europeu Estudo das Es- pondiloartrites (ESSG), acompanhados 29 centros referência Reumatologia no Brasil. Variáveis clínicas e demográficas foram obtidas avaliadas, analisando-se suas correlações DMD metotrexato (MTX) sulfasalazina (SSZ)....
<h3>Background</h3> Tofacitinib is an oral JAK inhibitor for the treatment of RA. can be given as monotherapy or with csDMARDs. Published data on real world (RW) tofacitinib use in Latin America (LA) are limited. We characterise patient (pt) population starting and gain insights into safety profile RW LA setting. <h3>Methods</h3> Initial therapies adult RA pts from 10 private/public centres 6 countries (Argentina, Brazil, Colombia, México, Panamá, Perú) were considered. Data retrospectively...
To analyze the clinical and epidemiologic characteristics of juvenile-onset spondyloarthritis (SpA) (< 16 years) compare them with a group adult-onset (≥ SpA patients. Prospective, observational multicentric cohort 1,424 patients diagnosis according to European Spondyloarthropathy Study Group (ESSG) submitted common protocol investigation recruited in 29 reference centers participants Brazilian Registry Spondyloarthritis (RBE – Registro Brasileiro de Espondiloartrites). Patients were divided...
<h3>Background:</h3> Breakthrough COVID-19 infections occurring in fully vaccinated people have been described. There is particular concern about the effectiveness of vaccination patients with immune-mediated rheumatic diseases (IMRD). Data on characteristics and prognosis breakthrough among IMRD are scarce. <h3>Objectives:</h3> To describe demographic clinical characteristics, presentation, risk factors associated hospitalization this population. <h3>Methods:</h3> SAFER study a Brazilian...
Apoplexia pituitária aguda é fenômeno relativamente raro, mesmo em macroadenomas. No entanto, a presença de áreas necro-hemorrágicas intratumorais nestes tumores que não se relacionam qualquer sintomatologia parece ser bem mais frequente do imaginava na era da tomografia. Com o advento ressonância magnética estas podem facilmente diagnosticadas pré-operatoriamente. Dentre os 40 últimos macroadenomas operados e examinados com RMN, 10 possuíam apopléticas subclínicas seu interior. Sete destes...
<h3>Background:</h3> Spondyloarthritis (SpA) has been classified as an 'MHC-I-opathy,' with HLA-B27 recognized a major genetic factor half century ago [1]. Additionally, other MHC-I alleles, including HLA-B7, B35, B38, and B40 (B60/B61), have implicated in increasing the risk of SpA [2-4]. A recent publication from our group showed overall positivity rate 4.35% Brazilian healthy people [5]. <h3>Objectives:</h3> To evaluate each allelic frequency (AF) HLA-B to assess whether frequencies...