A5038629290- Microbial Natural Products and Biosynthesis
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Antifungal resistance and susceptibility
- Fungal Biology and Applications
- Fungal Infections and Studies
- Mycotoxins in Agriculture and Food
- Phytochemical compounds biological activities
- Genomics and Phylogenetic Studies
- Plant tissue culture and regeneration
- Microbial Metabolic Engineering and Bioproduction
- Fungal and yeast genetics research
- Metabolomics and Mass Spectrometry Studies
- Biofuel production and bioconversion
- Phytoplasmas and Hemiptera pathogens
- Essential Oils and Antimicrobial Activity
- Plant Pathogenic Bacteria Studies
- Plant biochemistry and biosynthesis
- Sugarcane Cultivation and Processing
- Microbial Community Ecology and Physiology
- Extracellular vesicles in disease
- Enzyme Catalysis and Immobilization
- Phytochemicals and Antioxidant Activities
- Probiotics and Fermented Foods
- Marine Sponges and Natural Products
Universidade Estadual de Campinas (UNICAMP)
2016-2025
National Institute of Science and Technology
2025
Royal Society of Chemistry
2023
Cambridge Consultants (United Kingdom)
2023
Sociedade Brasileira de Química
2023
IQ Samhällsbyggnad
2023
Institute of Chemistry
2020
Pontifícia Universidade Católica de Campinas
2020
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2019
Universidade Federal de São Carlos
2007-2014
Abstract Aspergillus fumigatus is a saprophytic fungus that can cause variety of human diseases known as aspergillosis. Mycotoxin gliotoxin (GT) production important for its virulence and must be tightly regulated to avoid excess toxicity the fungus. GT self-protection by GliT oxidoreductase GtmA methyltransferase activities related subcellular localization these enzymes how sequestered from cytoplasm increased cell damage. Here, we show GliT:GFP GtmA:GFP are localized in vacuoles during...
During the postharvest period, citrus fruits can be affected by phytopathogens such as Penicillium digitatum , which causes green mold disease and is responsible for up to 90% of total losses. Chemical fungicides are widely used prevent disease, leading concerns about environmental health risks.
Abstract Numerous postharvest diseases have been reported that cause substantial losses of citrus fruits worldwide. Penicillium digitatum is responsible for up to 90% production losses, and represent a problem worldwide economy. In order control phytopathogens, chemical fungicides extensively used. Yet, the use some artificial concerns about environmental risks fungal resistance. Therefore, studies focusing on new approaches, such as natural products, are getting attention. Co-culture...
Covering: 2017-2019Guanidine natural products isolated from microorganisms, marine invertebrates and terrestrial plants, amphibians spiders, represented by non-ribosomal peptides, guanidine-bearing polyketides, alkaloids, terpenoids shikimic acid derived, are the subject of this review. The topics include discovery new metabolites, total synthesis guanidine compounds, biological activity mechanism-of-action, biosynthesis ecological functions.
Abstract Huanglongbing (HLB) is a disease of worldwide incidence that affects orange trees, among other commercial varieties, implicating in great losses to the citrus industry. The transmitted through Diaphorina citri vector, which inoculates Candidatus Liberibacter spp. plant sap. HLB lead blotchy mottle and fruit deformation, characteristic symptoms, induce drop affect negatively juice quality. Nowadays, controlled by eradication sick, symptomatic plants, coupled with psyllid control....
Chalcones are organic chromophores with diverse biological applications and potential for use in various electronic devices due to their recognized optical properties. This research focuses on the synthesis, FT-NMR characterization, biotransformation of three azachalcones (1–3) using Exserohilum rostratum fungus, yielding novel compounds (1a–3a). In vitro assays against Gram-positive Gram-negative bacteria revealed promising pharmacological these new chromophores. A key structural...
ABSTRACT The human pathogenic fungus Aspergillus fumigatus establishes dual biofilm interactions in the lungs with bacterium Pseudomonas aeruginosa . Screening of 21 A null mutants revealed seven (two G protein-coupled receptors, three mitogen-activated protein kinase a Gα protein, and one histidine receptor) reduced formation, specifically presence P. Transcriptional profiling metabolomics analysis secondary metabolites produced by these mutants, Δ gpaB ( encodes protein), showed GpaB...
Keeping it basic: Arginine provides the exotic 4-guanidinobutanoate starter unit for two different types of zwitterionic polyketide (an example one type is shown in picture) produced by same Streptomyces bacterium. The three-step precursor pathway initiated a remarkable decarboxylating monooxygenase with high specificity arginine. As service to our authors and readers, this journal supporting information supplied authors. Such materials are peer reviewed may be re-organized online delivery,...
Aspergillus fumigatus , one of the most important human-pathogenic fungal species, is able to cause aspergillosis, a heterogeneous group diseases that presents wide range clinical manifestations. Invasive pulmonary aspergillosis serious pathology in terms patient outcome and treatment, with high mortality rate ranging from 50% 95% primarily affecting immunocompromised patients. Azoles have been used for many years as main antifungal agents treat prevent invasive aspergillosis. However, there...
The small molecule (molecular mass <900 Daltons) composition of extracellular vesicles (EVs) produced by the pathogenic fungus Cryptococcus gattii is unknown, which limits understanding functions cryptococcal EVs. In this study, we analyzed molecules in samples obtained from solid cultures C. a combination chromatographic and spectrometric approaches, untargeted metabolomics. This analysis revealed previously unknown components EVs, including peptides with known biological other models....
Euterpe oleracea Mart. (açai) is a native palm from the Amazon region. There are various chemical constituents of açai with bioactive properties. This study aimed to evaluate composition and cytotoxic effects seed extract on breast cancer cell line (MCF-7). Global Natural Products Social Molecular Networking (GNPS) was applied identify compounds present in extract. LC-MS/MS molecular networking were employed detect phenolic açai. The antioxidant activity measured by DPPH assay. MCF-7...
Lignin is an attractive alternative for producing biobased chemicals. It the second major component of plant cell wall and abundant natural source aromatic compounds. degradation using microbial oxidative enzymes that depolymerize lignin catabolize compounds into central metabolic intermediates a promising strategy valorization. However, intrinsic heterogeneity recalcitrance severely hinder its biocatalytic conversion. In this context, examining systems can provide fundamental understanding...
ABSTRACT Small molecules are components of fungal extracellular vesicles (EVs), but their biological roles only superficially known. NOP16 is a eukaryotic gene that required for the activity benzimidazoles against Cryptococcus deuterogattii . In this study, during phenotypic characterization C. mutants expected to lack expression, we observed reduced EV production. Whole-genome sequencing, RNA-Seq, and cellular proteomics revealed that, contrary our initial findings, these expressed Nop16...
Abstract Aspergillus fumigatus represents a public health problem due to the high mortality rate in immunosuppressed patients and emergence of antifungal-resistant isolates. Protein acetylation is crucial post-translational modification that controls gene expression biological processes. The strategic manipulation enzymes involved protein has emerged as promising therapeutic approach for addressing fungal infections. Sirtuins, NAD + -dependent lysine deacetylases, regulate eukaryotes....
Abstract Aspergillus fumigatus is the main causative agent of invasive pulmonary aspergillosis (IPA), a severe disease that affects immunosuppressed patients worldwide. The fungistatic drug caspofungin (CSP) second line therapy against IPA but has increasingly been used clinical strains are resistant to azoles, first antifungal therapy. In high concentrations, CSP induces tolerance phenotype with partial reestablishment fungal growth called paradoxical effect (CPE), resulting from change in...