A5034656519- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Synthesis and Characterization of Heterocyclic Compounds
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Fungal Biology and Applications
- Synthesis and Biological Activity
- Plant Pathogens and Fungal Diseases
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- X-ray Diffraction in Crystallography
- Aquaculture disease management and microbiota
- Crystallization and Solubility Studies
- Marine Toxins and Detection Methods
- Synthesis and biological activity
- Biotechnology and Related Fields
- Synthesis and Catalytic Reactions
- Carbohydrate Chemistry and Synthesis
- Synthesis of Organic Compounds
- Aquaculture Nutrition and Growth
- Synthesis and Biological Evaluation
- Research on Leishmaniasis Studies
- Chemical Reaction Mechanisms
- Microbial Metabolic Engineering and Bioproduction
Universidade de São Paulo
2016-2025
Universidade Federal de São Carlos
2015-2025
Instituto de Psicologia Comportamental de São Carlos
2015-2025
University of California, Irvine
2016
Universidade Brasil
2012
Hospital Universitário da Universidade de São Paulo
2012
Fundação de Amparo à Pesquisa do Estado de São Paulo
2012
Universidade Estadual de Campinas (UNICAMP)
2010
Universidade Federal do Rio de Janeiro
2000-2009
University of British Columbia
1998-2009
Covering: 2002 to 2004. Previous review: Nat. Prod. Rep., 2002, 19, 617–649
The world is in the midst of a biodiversity crisis, threatening essential goods and services on which humanity depends.While there an urgent need globally for research, growing obstacles are severely limiting research throughout developing world, particularly southeast Asia.Facilities, funding, expertise often limited this region, reducing capacity local research.Although western scientists generally have more capacity, international has sometimes been exploitative "parachute science,"...
HPLC-UV-ELSD-MS-guided fractionation of the anti-parasitic extract obtained from marine sponge Monanchora arbuscula, collected off southeastern coast Brazil, led to isolation a series guanidine and pyrimidine alkaloids. The pyrimidines monalidine A (1) arbusculidine (7), as well alkaloids batzellamide (8) hemibatzelladines 9–11, represent new minor constituents that were identified by analysis spectroscopic data. total synthesis confirmed its structure. Arbusculidine related...
Marine sponges are the oldest Metazoa, very often presenting a complex microbial consortium. Such is case of marine sponge Arenosclera brasiliensis, endemic to Rio de Janeiro State, Brazil. In this investigation we characterized diversity some culturable heterotrophic bacteria living in association with A. brasiliensis and determined their antimicrobial activity. The genera Endozoicomonas (N = 32), Bacillus 26), Shewanella 17), Pseudovibrio 12), Ruegeria 8) were dominant among recovered...
During the postharvest period, citrus fruits can be affected by phytopathogens such as Penicillium digitatum , which causes green mold disease and is responsible for up to 90% of total losses. Chemical fungicides are widely used prevent disease, leading concerns about environmental health risks.
Natural products (or specialized metabolites) are historically the main source of new drugs. However, current drug discovery pipelines require miniaturization and speeds that incompatible with traditional natural product research methods, especially in early stages research. This article introduces NP3 MS Workflow, a robust open-source software system for liquid chromatography–tandem mass spectrometry (LC–MS/MS) untargeted metabolomic data processing analysis, designed to rank bioactive...
Crude methanol extracts of the ascidian Didemnum granulatum collected in Brazil showed activity a new screen for G2 cell cycle checkpoint inhibitors. Bioassay-guided fractionation extract yielded known alkaloids didemnimides A (1) and D (2), alkaloid didemnimide E (3), inhibitor. Two candidate structures inhibitor, named granulatimide (4) isogranulatimide (5), have been prepared via short efficient biomimetic synthesis involving photolysis (1). The revealed that correct structure naturally...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolycyclic Guanidine Alkaloids from the Marine Sponge Crambe crambe and Ca++ Channel Blocker Activity of Crambescidin 816R. G. S. Berlinck, J. C. Braekman, D. Daloze, I. Bruno, R. Riccio, Ferri, Spampinato, E. SperoniCite this: Nat. Prod. 1993, 56, 7, 1007–1015Publication Date (Print):July 1, 1993Publication History Published online1 July 2004Published inissue 1...