A5066230640- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Plant-Microbe Interactions and Immunity
- Marine Sponges and Natural Products
- Synthetic Organic Chemistry Methods
- Plant biochemistry and biosynthesis
- Genomics and Phylogenetic Studies
- Plant Pathogens and Fungal Diseases
- Insect symbiosis and bacterial influences
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Mycorrhizal Fungi and Plant Interactions
- Plant Pathogenic Bacteria Studies
- Microbial Metabolism and Applications
- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Legume Nitrogen Fixing Symbiosis
- Nematode management and characterization studies
- Synthesis and Catalytic Reactions
- Biochemical and Structural Characterization
- Microbial Metabolic Engineering and Bioproduction
- Mycotoxins in Agriculture and Food
- Antifungal resistance and susceptibility
- Fungal and yeast genetics research
- Phytochemical compounds biological activities
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2016-2025
Friedrich Schiller University Jena
2016-2025
Czech Academy of Sciences, Institute of Microbiology
2025
Schiller International University
2008-2021
GP Batteries (China)
2020
Robert Bosch (Germany)
2020
Laboratoire de Chimie Moléculaire et Thioorganique
2020
Lithium Power (United States)
2020
Faculty (United Kingdom)
2019
Schiller (France)
2019
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded biosynthetic gene clusters. Information about these clusters, is currently dispersed throughout the literature, making it difficult exploit. To facilitate consistent systematic deposition retrieval data on we propose Minimum a Biosynthetic Gene cluster (MIBiG) standard.
Fungi produce numerous low molecular weight molecules endowed with a multitude of biological activities. However, mining the full-genome sequences fungi indicates that their potential to secondary metabolites is greatly underestimated. Because most biosynthesis gene clusters are silent under laboratory conditions, one major challenges understand physiological conditions which these genes activated. Thus, we cocultivated important model fungus Aspergillus nidulans collection 58 soil-dwelling...
Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it seems that many valuable compounds overlooked when culturing microbes under standardized laboratory conditions. Many biosynthesis genes remain silent and such "cryptic" or "orphan" pathways only activated specific This report gives an overview on the strategies to trigger biosynthetic yield "cryptic natural products" through external cues, co-cultivation genomic approaches as genome-mining,...
Sequence analyses of fungal genomes have revealed that the potential fungi to produce secondary metabolites is greatly underestimated. In fact, most gene clusters coding for biosynthesis antibiotics, toxins, or pigments are silent under standard laboratory conditions. Hence, it one major challenges in microbiology uncover mechanisms required pathway activation. Recently, we discovered intimate physical interaction important model fungus Aspergillus nidulans with soil-dwelling bacterium...
Cloning, sequencing and gene analysis of the rhi locus in genome rhizoxin-producing bacterial endosymbiont "Burkholderia rhizoxina" rice-pathogenic fungus Rhizopus microsporus provides first insight into giant trans-AT NRPS–PKS thiotemplate assembly line for potent antimitotic macrolide.
Abstract Molekulares Lego : Polyketide bilden eine äußerst vielfältige Gruppe von Naturstoffen mit faszinierenden Kohlenstoffgerüsten (siehe Beispiele), die aus einfachen Acyl‐Bausteinen synthetisiert werden. Das Zusammenspiel Chemie, Biochemie und Genetik lieferte wichtige Einblicke in Programmierung des Polyketid‐Aufbaus beteiligten, komplexen Enzymsysteme. Dieser Aufsatz behandelt aktuelle Entwicklungen auf diesem Forschungsgebiet. magnified image der größten Naturstoffklassen. Viele...
Abstract Background Millions of humans and animals suffer from superficial infections caused by a group highly specialized filamentous fungi, the dermatophytes, which exclusively infect keratinized host structures. To provide broad insights into molecular basis pathogenicity-associated traits, we report first genome sequences two closely phylogenetically related Arthroderma benhamiae Trichophyton verrucosum , both induce inflammatory in humans. Results 97% 22.5 megabase A. T. are...
Several strains of the fungus Rhizopus microsporus harbour endosymbiotic bacteria for production causal agent rice seedling blight, rhizoxin, and toxic cyclopeptide rhizonin. R. isolated endobacteria were selected freeze-fracture electron microscopy, which allowed visualization bacterial cells within fungal cytosol by their two parallel-running envelope membranes fine structure lipopolysaccharide layer outer membrane. Two representatives endosymbionts chosen phylogenetic analyses on basis...