Matthias Platzer
A5042480855- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Genomics and Chromatin Dynamics
- Plant Disease Resistance and Genetics
- Evolution and Paleontology Studies
- CRISPR and Genetic Engineering
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Plant Pathogens and Fungal Diseases
- Physiological and biochemical adaptations
- Wheat and Barley Genetics and Pathology
- Testicular diseases and treatments
- Advanced biosensing and bioanalysis techniques
- Urologic and reproductive health conditions
- MicroRNA in disease regulation
- Fish Biology and Ecology Studies
- Fish biology, ecology, and behavior
- Genetic Syndromes and Imprinting
- Genomic variations and chromosomal abnormalities
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2014-2024
Leibniz Institute for Zoo and Wildlife Research
2020
Leibniz Institute for Neurobiology
2018
Leibniz Association
2006-2015
National Institutes of Health
2011-2012
University of Cologne
2012
Helmholtz Zentrum München
2009
Leibniz Institute of Plant Genetics and Crop Plant Research
2009
Schiller International University
2009
University of Duisburg-Essen
2009
Barley (Hordeum vulgare L.) is among the world's earliest domesticated and most important crop plants. It diploid with a large haploid genome of 5.1 gigabases (Gb). Here we present an integrated ordered physical, genetic functional sequence resource that describes barley gene-space in structured whole-genome context. We developed physical map 4.98 Gb, more than 3.90 Gb anchored to high-resolution map. Projecting deep shotgun assembly, complementary DNA RNA data onto this framework supports...
Cereal grasses of the Triticeae tribe have been major food source in temperate regions since dawn agriculture. Their large genomes are characterized by a high content repetitive elements and pericentromeric that virtually devoid meiotic recombination. Here we present high-quality reference genome assembly for barley (Hordeum vulgare L.). We use chromosome conformation capture mapping to derive linear order sequences across space investigate spatial organization chromatin nucleus at megabase...
Bacterial symbionts have long been suspected to be the true producers of many drug candidates isolated from marine invertebrates. Sponges, most important source biologically active natural products, frequently hypothesized contain compounds bacterial origin. This symbiont hypothesis, however, remained unproven because a general inability cultivate producers. However, we recently identified an uncultured Pseudomonas sp. as likely producer defensive antitumor polyketide pederin in Paederus...
We used a novel approach that incorporated chromosome sorting, next-generation sequencing, array hybridization, and systematic exploitation of conserved synteny with model grasses to assign ~86% the estimated ~32,000 barley (Hordeum vulgare) genes individual arms. Using series bioinformatically constructed genome zippers integrate gene indices rice (Oryza sativa), sorghum (Sorghum bicolor), Brachypodium distachyon in model, we were able assemble 21,766 putative linear order. show (H)...
So far, the annotation of translation initiation sites (TISs) has been based mostly upon bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to puromycin-treated cells generate a transcriptome-wide map TISs in human monocytic cell line. A neural network was trained on footprints observed at previously annotated AUG codons (TICs), and used for ab initio prediction 5062 transcripts with sufficient sequence coverage. Functional interpretation suggested 2994 novel...
Abstract D -Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism activates AMP-activated protein kinase (AMPK/AAK-2) increases mitochondrial biogenesis. Consistent with concept mitohormesis, GlcN promotes increased formation reactive oxygen...
Autosomal dominant inheritance of mutations in the melanocortin-4 receptor gene (MC4R) is currently regarded as most relevant genetic cause for extreme obesity and affects 2-4% extremely obese individuals.Our objective was to assess relevance MC4R a German population-based sample.We conducted mutation screen by capillary electrophoresis-based single-strand conformation polymorphism analysis denaturing HPLC.Subjects included 4068 individuals study group [Kooperative Gesundheitsforschung im...
Abstract All six arms of the group 1 chromosomes hexaploid wheat (Triticum aestivum) were sequenced with Roche/454 to 1.3- 2.2-fold coverage and compared similar data sets from homoeologous chromosome 1H barley (Hordeum vulgare). Six ten thousand gene sequences sampled per chromosome. These classified into genes that have their closest homologs in Triticeae syntenic region Brachypodium, rice (Oryza sativa), and/or sorghum (Sorghum bicolor) elsewhere these model grass genomes. Although number...
Abstract Background Millions of humans and animals suffer from superficial infections caused by a group highly specialized filamentous fungi, the dermatophytes, which exclusively infect keratinized host structures. To provide broad insights into molecular basis pathogenicity-associated traits, we report first genome sequences two closely phylogenetically related Arthroderma benhamiae Trichophyton verrucosum , both induce inflammatory in humans. Results 97% 22.5 megabase A. T. are...
Dictyostelium discoideum (DD), an extensively studied model organism for cell and developmental biology, belongs to the most derived group 4 of social amoebas, a clade altruistic multicellular organisms. To understand genome evolution over long time periods genetic basis evolution, we sequenced genomes fasciculatum (DF) Polysphondylium pallidum (PP), which represent early diverging groups 1 2, respectively. In contrast DD, PP DF have conventional telomere organization strongly reduced...