A5100650543- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Gut microbiota and health
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Acupuncture Treatment Research Studies
- Reproductive Biology and Fertility
- Cell death mechanisms and regulation
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Healthcare and Venom Research
- Chromosomal and Genetic Variations
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Nanoplatforms for cancer theranostics
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Neurological Disease Mechanisms and Treatments
Eye & ENT Hospital of Fudan University
2018-2025
Changzhou University
2025
Qilu Hospital of Shandong University
2025
Nanjing University of Chinese Medicine
2018-2024
Nankai University
2016-2024
State Key Laboratory of Medicinal Chemical Biology
2016-2024
Zhengzhou University
2008-2024
Tianjin Medical University General Hospital
2022-2024
Anqing City Hospital
2024
Sichuan Agricultural University
2020-2024
Metagenomic approaches demonstrate that the human placenta is not sterile but harbors a unique microbiome.
Abstract Purpose: To investigate the molecular mechanism underlying intrinsic resistance to ABT-199. Experimental Design: Western blots and real-time RT-PCR were used determine levels of Mcl-1 after ABT-199 treatment alone or in combination with cytarabine daunorubicin. Immunoprecipitation Bim effect on their interactions Bcl-2 family members. Lentiviral short hairpin RNA knockdown CRISPR confirm role JC-1 assays flow cytometry drug-induced apoptosis. Results: from ABT-199–treated cell lines...
Gastric cancer (GC) remains one of the most common types malignant cancer, and molecular mechanism underlying its metastasis is still largely unclear. MicroRNAs have emerged as important regulators because their ability to act on multiple signaling pathways. In our study, we found that miR-144 significantly downregulated in both highly metastatic GC cell lines tissues. Results from gain-of-function loss-of-function experiments demonstrate increased expression reduced migration, whereas...
CTCF is a multifunctional nuclear factor involved in epigenetic regulation. Despite recent advances that include the systematic discovery of CTCF-binding sites throughout mammalian genome, vivo roles adult tissues and during embryonic development are largely unknown. Using transgenic RNAi, we depleted maternal stores from growing mouse oocytes, identified hundreds misregulated genes. Moreover, our analysis suggests predominantly activates or derepresses transcription oocytes. depletion...
To investigate the efficacy of combination FLT3 inhibitors midostaurin or gilteritinib with Bcl-2 inhibitor venetoclax in FLT3-internal tandem duplication (ITD) acute myeloid leukemia (AML) and underlying molecular mechanism.Using both FLT3-ITD cell lines primary patient samples, Annexin V-FITC/propidium iodide staining flow cytometry analysis were used to quantify death induced by gilteritinib, alone venetoclax. Western blot was performed assess changes protein expression levels members...
Retrotransposons are “copy-and-paste” insertional mutagens that substantially contribute to mammalian genome content. often carry long terminal repeats (LTRs) for retrovirus-like reverse transcription and integration into the genome. We report an extraordinary impact of a group LTRs from endogenous retrovirus-related ERVL retrotransposon class on gene expression in germline beyond. In mouse, we identified more than 800 ORR1, MT, MT2, MLT families, which resemble mobile gene-remodeling...
Radiotherapy performs an important function in the treatment of cancer, but resistance tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed overcome such and thereby improve outcome. The goal this study was evaluate compare radiosensitizing efficacies gold nanoparticles (AuNPs) silver (AgNPs) glioma at clinically relevant megavoltage energies. Both AuNPs AgNPs potentiated vitro vivo antiglioma effects radiation. showed...
The efficacy of radiotherapy for glioma is often limited by the radioresistance cells. radiosensitizing effects silver nanoparticles (AgNPs) on were found in previous studies our group. In order to enhance radiosensitivity tumor cells and selectively kill them while reducing side irradiation therapy, targeted modification AgNPs urgently needed.In present study, functionalized with polyethylene glycol (PEG) aptamer As1411 (AsNPs) synthesized subsequently characterized transmission electron...
Overexpression of the proinflammatory cytokine IL-1β is associated with diverse diseases, including cancer. Alteration microRNAs has been observed in cancer cells exposed to cytokines, yet their function inflammation stress remains elusive. Here, we show that induces upregulation miR-425, which negatively regulates phosphatase and tensin homolog expression by targeting its 3' UTR. An increase miR-425 depends on IL-1β-induced NF-kappaB activation, enhances gene transcription upon induction....
Abstract Background Although our microbial community and genomes (the human microbiome) outnumber genome by several orders of magnitude, to what extent the host genetic complement informs microbiota composition is not clear. The Human Microbiome Project (HMP) Consortium established a unique population-scale framework with which characterize relationship structure their hosts. A wide variety taxa metabolic pathways have been shown be differentially distributed virtue race/ethnicity in HMP....
Abstract The woman’s gut microbiota during pregnancy may support nutrient acquisition, is associated with diseases, and has been linked to infant health. However, there limited information on microbial characteristics dependence in pregnant women. In this study, we provide a comprehensive overview of the 1479 women using 16S rRNA gene sequencing fecal samples. We identify core women, which displays similar overall structure that age-matched nonpregnant Our data show gestational...
Smad nuclear-interacting protein 1 (SNIP1) is a transcription repressor related to the TGF-β signaling pathway and associates with c-MYC, key regulator of cell proliferation tumor development. Currently, mechanism by which SNIP1 regulates tumorigenesis cancer metastasis unknown. Here, we identify that non-histone substrate lysine methyltransferase KMT5A, undergoes KMT5A-mediated mono-methylation promote breast growth, invasion lung metastasis. Mechanistically, show K301 methylation...
Spinal cord injury (SCI) is a traumatic condition that results in impaired motor and sensory function. Ferroptosis one of the main causes neural cell death loss neurological function spinal cord, ferroptosis inhibitors are effective reducing inflammation repairing SCI. Although human umbilical mesenchymal stem cells (Huc-MSCs) can ameliorate inflammatory microenvironments promote regeneration SCI, their efficacy greatly limited by local microenvironment after Therefore, this study, we...
Matrix metalloproteinases (MMPs) are known to play important roles in extracellular matrix remodeling during the process of tumor invasion and metastasis. However, little is about their role esophageal squamous cell carcinoma (ESCC). Expression MMP-2 MMP-9 ESCC was detected our research. Tissue microarray chip prepared, consisting 58 cases corresponding epithelium tissues. were examined by immunohistochemistry. Overexpression found (42.1 60.3%, respectively), compared with paired distal...
Abstract The elevated incidence of aneuploidy in human oocytes warrants study the molecular mechanisms regulating proper chromosome segregation. Aurora kinases are a well‐conserved family serine/threonine that involved segregation during mitosis and meiosis. Here we report expression localization all three kinase homologs, AURKA, AURKB, AURKC, meiotic maturation mouse oocytes. most abundantly expressed homolog, localizes to spindle poles meiosis I (MI) II (MII), whereas AURKB is concentrated...
The oocyte-to-zygote transition entails transforming a highly differentiated oocyte into totipotent blastomeres and represents one of the earliest obstacles that must be successfully hurdled for continued development. Degradation maternal mRNAs, which likely lies at heart this transition, is characterized by from mRNA stability to instability during maturation. Although phosphorylation oocyte-specific RNA-binding protein MSY2 maturation implicated in making mRNAs more susceptible...