A5040712353- Reproductive tract infections research
- Preterm Birth and Chorioamnionitis
- Blood groups and transfusion
- Microbial infections and disease research
- Syphilis Diagnosis and Treatment
- Genital Health and Disease
- Reproductive System and Pregnancy
- Herpesvirus Infections and Treatments
- Infant Nutrition and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Urological Disorders and Treatments
- Palliative Care and End-of-Life Issues
- HIV, TB, and STIs Epidemiology
- Pediatric health and respiratory diseases
- Nursing Roles and Practices
- Bacterial Infections and Vaccines
- Salivary Gland Disorders and Functions
- Global Health Workforce Issues
- Carbohydrate Chemistry and Synthesis
- Enzyme Production and Characterization
- Extracellular vesicles in disease
- Toxoplasma gondii Research Studies
The University of Queensland
2015-2025
Queensland University of Technology
2013-2023
University Hospital Southampton NHS Foundation Trust
2017
Royal Brisbane and Women's Hospital
2015-2016
Colchester Hospital
2016
University College London Hospitals NHS Foundation Trust
2006
University College London
2006
Chase Farm Hospital
2006
Barnet and Chase Farm NHS Hospitals Trust
2006
Although there is significant interest in elucidating the role of placenta-derived exosomes (PdEs) during pregnancy, exosomal profile pregnancies complicated by gestational diabetes mellitus (GDM) remains to be established. The aim this study was compare gestational-age PdEs maternal plasma GDM with normal and determine effect on cytokine release from human umbilical vein endothelial cells. A prospective cohort patients sampled at three time points pregnancy for each patient (i.e., 11–14,...
Abstract Syphilis, which is caused by the sexually transmitted bacterium Treponema pallidum subsp. , has an estimated 6.3 million cases worldwide per annum. In past ten years, incidence of syphilis increased more than 150% in some high-income countries, but evolution and epidemiology epidemic are poorly understood. To characterize global population structure T. we assembled a geographically temporally diverse collection 726 genomes from 626 clinical 100 laboratory samples collected 23...
Context: Hyperglycemia and hypoxia are risk factors of metabolic complication during pregnancy. The interactions between oxygen glucose-sensing pathways that regulate exosome bioactivity from placental cells, however, have not been established. Objective: aim this study was to test the hypothesis exosomal signaling by cells (defined as number exosomes released per unit time their bioactivity) is responsive extracellular glucose concentration. Methods: First-trimester primary trophoblast were...
We know very little about the microbiota inhabiting upper female reproductive tract and how it impacts on fertility.This pilot study aimed to examine vaginal, cervical endometrial for women with a history of infertility compared fertility.Using retrospective case-control design, were recruited collection samples. The composition was analysed by 16S ribosomal RNA (rRNA) gene amplification expression selected human genes quantitative reverse transcription polymerase chain reaction.Sixty-five...
Introduction Xanthine oxidase (XO) is distributed in mammals largely the liver and small intestine, but also highly active milk where it generates hydrogen peroxide (H2O2). Adult human saliva low hypoxanthine xanthine, substrates of XO, high lactoperoxidase substrate thiocyanate, neonates has not been examined. Results Median concentrations xanthine neonatal (27 19 μM respectively) were ten-fold higher than adult (2.1 1.7 μM). Fresh breastmilk contained 27.3±12.2 H2O2 mixing baby with...
Prevalence, trends, and treatment outcome estimates were generated for parC variants in macrolide-resistant Mycoplasma genitalium. Among 539 cases, the most common amino acid change was S83I, which increased from 13% 2012 to 2013, 23% 2019 2020 (Ptrend = 0.046). From 381 moxifloxacin treatments, failure occurred 58.7% (95% confidence interval [CI], 46.7 69.9) of cases with S83I. Other changes affecting S83 or D87 uncommon minor contributors failure. The absence S83I highly predictive cure...
Abstract Background Mycoplasma genitalium (MG) infection is challenging to cure because of rising antimicrobial resistance and limited treatment options. Methods This was a prospective evaluation the efficacy tolerability resistance-guided combination therapy for MG at Melbourne Sexual Health Centre (August 2019–December 2020). All patients received 7 days doxycycline before based on macrolide-resistant profile. Macrolide-susceptible infections + azithromycin (1 g, day 1; 500 mg, 2–4)...
Although single nucleotide polymorphisms (SNPs) in Mycoplasma genitalium parC contribute to fluoroquinolone treatment failure, data are limited for the homologous gene, gyrA. This study investigated prevalence of gyrA SNPs and their contribution failure.Samples from 411 patients (male female) undergoing M. infection (Melbourne Sexual Health Centre, March 2019-February 2020) were analyzed by Sanger sequencing (gyrA parC). For treated with moxifloxacin (n = 194), association between...
Objective. The human Ureaplasma species are the microbes most frequently isolated from placentae of women who deliver preterm. role has been investigated in pregnancies at <32 weeks gestation, but currently no studies have determined prevalence ureaplasmas moderately preterm and late-preterm (hereafter, "moderate/late preterm") infants, largest cohort infants. Methods. Women delivering moderate/late infants (n = 477) their infants/placentae 535) were recruited, swab specimens chorioamnion...
Abstract In utero and upon delivery, neonates are exposed to a wide array of microorganisms from various sources, including maternal bacteria. Prior studies have proposed that the mode feeding shapes gut microbiota and, subsequently child’s health. However, effect its influence on development neonatal oral in early infancy has not yet been reported. The aim this study was compare healthy infants were exclusively breast-fed or formula-fed using 16S-rRNA gene sequencing. We demonstrated...
Background: Contemporary estimates of macrolide and fluroquinolone resistance in Mycoplasma genitalium are needed to inform national, regional, global treatment guidelines. Methods: This is an update a previous systematic review meta-analysis performed up Dec 2018. In this we searched PubMed, Embase, MEDLINE from Jan 1, 2019 Apr 18, 2023 for published studies reporting macrolide, fluoroquinolone, dual-class (macrolide fluoroquinolone) M. genitalium. Data were combined with the examine trends...
Mycoplasma genitalium is frequently associated with urogenital and rectal infections, the number of cases macrolide-resistant quinolone-resistant M. infection continuing to increase. In this study, we examined levels resistance these two common antibiotic treatments in geographically distinct locations Queensland, Australia.
Abstract Neonates are exposed to microbes in utero and at birth, thereby establishing their microbiota (healthy microbial colonisers). Previously, we reported significant differences the neonatal oral of breast-fed formula-fed babies after first discovering a primal metabolic mechanism that occurs when breastmilk (containing enzyme xanthine oxidase) saliva highly elevated concentrations substrates for oxidase: hypoxanthine). The interaction breast milk releases antibacterial compounds...
Antimicrobial resistance (AMR) is a major problem in the field of sexually transmitted infections (STIs), where escalating levels have coincided with surge infections. The individualised treatment STIs by rapid molecular ‘resistance’ assays new approach to patient management that has developed through understanding mechanisms resistance, combined nucleic acid amplification diagnostics. Mycoplasma genitalium provides an excellent example this because restricted repertoire effective...