A5011848799- Vector-borne infectious diseases
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Vector-Borne Animal Diseases
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Helicobacter pylori-related gastroenterology studies
- Fungal Infections and Studies
- Insect and Pesticide Research
- Antifungal resistance and susceptibility
- Zoonotic diseases and public health
- HIV, Drug Use, Sexual Risk
- Galectins and Cancer Biology
- Long-Term Effects of COVID-19
- Yersinia bacterium, plague, ectoparasites research
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Nail Diseases and Treatments
- Female Genital Mutilation/Cutting Issues
- Mycobacterium research and diagnosis
- Vibrio bacteria research studies
- HIV/AIDS Research and Interventions
BC Centre for Disease Control
2016-2025
University of British Columbia
2016-2025
Sher-e-Bangla Agricultural University
2025
Response Biomedical (Canada)
2024
Mahidol Oxford Tropical Medicine Research Unit
2023
Mahidol University
2023
University of Oxford
2023
Research Institute for Tropical Medicine
2023
Kumamoto University
2023
Provincial Health Services Authority
2011-2022
Abstract Syphilis, which is caused by the sexually transmitted bacterium Treponema pallidum subsp. , has an estimated 6.3 million cases worldwide per annum. In past ten years, incidence of syphilis increased more than 150% in some high-income countries, but evolution and epidemiology epidemic are poorly understood. To characterize global population structure T. we assembled a geographically temporally diverse collection 726 genomes from 626 clinical 100 laboratory samples collected 23...
The urease of Helicobacter pylori has been proposed to be one its pathogenic factors. A kanamycin resistance determinant was inserted in a cloned gene, and transformation-mediated allelic exchange mutagenesis carried out introduce the disrupted gene into corresponding wild-type chromosomal region clinical isolate H. pylori, CPY3401. resulting mutant, HPT73, had null activity urease. Nude mouse stomachs were challenged with these two isogenic strains examine role pathogenesis. Gastritis found...
Abstract Cryptococcus gattii, emergent on Vancouver Island, British Columbia (BC), Canada, in 1999, was detected during 2003–2005 3 persons and 8 animals that did not travel to Island the incubation period; positive environmental samples were areas outside Island. All clinical isolates found BC genotypically consistent with strains. In addition, local acquisition cats Washington 2 Oregon. The molecular profiles of Oregon differed from those Washington. Although some microclimates Pacific...
A total of 152 ixodid ticks (Acari: Ixodidae) consisting nine species was collected from 82 passerine birds (33 species) in 14 locations Canada 1996 to 2000. The Lyme disease spirochete Borrelia burgdorferi Johnson, Schmidt, Hyde, Steigerwaldt & Brenner cultured the nymph a blacklegged tick, Ixodes scapularis Say, that had been removed common yellowthroat, Geothlypis trichas L., Bon Portage Island, Nova Scotia. As result bird movement, nymphal I. Swainson's thrush, Catharus ustulatus incanus...
During a 3-yr comprehensive study, 196 ixodid ticks (9 species) were collected from 89 passerine birds (32 25 localities across Canada to determine the distribution of avian-associated tick species and endogenous Lyme disease spirochetes, Borrelia burgdorferi Johnson, Schmid, Hyde, Steigerwalt, Brenner. We report following first records parasitism on avian hosts: rabbit-associated tick, Ixodes dentatus Marx, Manitoba Ontario; mouse muris Bishopp Smith, British Columbia; blacklegged...
Lyme disease is reported across Canada, but pinpointing the source of infection has been problematic. In this three-year, bird-tick-pathogen study (2004-2006), 366 ticks representing 12 species were collected from 151 songbirds (31 passerine species/subspecies) at 16 locations Canada-wide. Of 167 ticks/pools tested, 19 (11.4%) infected with Borrelia burgdorferi sensu lato (s.l.). Sequencing rrf-rrl intergenic spacer gene revealed four genotypes: B. stricto (s.s.) and three novel genotypes...
Abstract Background. Cryptococcus gattii (Cg) infection emerged in British Columbia 1999. A longitudinal, clinical description of patients has not been reported. Methods. Medical records were reviewed for Cg identified through surveillance (1999–2007). Risk factors mortality explored using multivariate Cox regression; longitudinal patterns serum cryptococcal antigen (SCrAg) titers and the probability chest cryptococcomas over time estimated cubic B-splines mixed-effects regression models....
Abstract Background The province of British Columbia (BC) has been recognized for successful SARS-CoV-2 control, with surveillance data showing amongst the lowest case and death rates in Canada. We estimate sero-prevalence two periods flanking start (March) end (May) first-wave mitigation measures BC. Methods Serial cross-sectional sampling was conducted using anonymized residual sera obtained from an outpatient laboratory network, including children adults Greater Vancouver Area (population...
The primary vectors of the agent Lyme disease in Canada are Ixodes scapularis and pacificus ticks. Surveillance for ticks pathogens they can transmit inform local tick-borne risk guide public health interventions. objective this article is to characterize passive active surveillance main tick 2019 carry.Passive data were compiled from National Microbiology Laboratory Branch provincial sources. Active was conducted selected sentinel sites all provinces. Descriptive analysis submitted...
A subset of patients reporting a diagnosis Lyme disease can be described as having alternatively diagnosed chronic syndrome (ADCLS), in which is based on laboratory results from nonreference specialty using in-house criteria. Patients with ADCLS report symptoms similar to those reported by fatigue (CFS).We performed case-control study comparing and CFS each other both healthy controls systemic lupus erythematosus (SLE). Subjects completed history, physical exam, screening tests, 7 functional...
Lyme disease is an emerging vector-borne zoonotic of increasing public health importance in Canada. As part its mandate, the Canadian Disease Research Network (CLyDRN) launched a pan-Canadian sentinel surveillance initiative, Sentinel (CaLSeN), 2019.To create standardized, national network providing real-time portrait evolving environmental risk each province.A multicriteria decision analysis (MCDA) approach was used selection regions. Within region, systematic drag sampling protocol...
Recently, a new strain of cholera, Vibrio cholerae O139, has emerged as an epidemic strain, but there is little information about its environmental reservoir. The present investigation was aimed to determine the role cyanobacteria in persistence V. O139 microcosms. An isolate and three (Anabaena sp., Nostoc Hapalosiphon sp.) were used this study. Survival culturable microcosms monitored using taurocholate-tellurite gelatin agar medium. Viable nonculturable detected fluorescent antibody...
The environmental fungus Cryptococcus gattii emerged on Vancouver Island, British Columbia (BC), in 1999. By the end of 2006, it led to 176 cases and eight deaths - one highest burdens C disease worldwide. present paper describes three cases, BC experience diagnosis management this infection. All presented with pulmonary findings, including cryptococcomas infiltrates. One also brain cryptococcomas. Cases were diagnosed by chest imaging, laboratory evidence serum or cerebrospinal fluid...
Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a of unknown etiology characterized by profound exacerbated physical activity, also known as post-exertional malaise (PEM). Previously, we did not detect evidence immune dysregulation or virus reactivation outside PEM periods. Here sought to determine whether cardiopulmonary exercise stress testing ME/CFS patients could trigger such changes. (n = 14) and matched sedentary controls 11) were subjected on 2 consecutive days...