A5082618365- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Clinical practice guidelines implementation
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Opioid Use Disorder Treatment
- Mosquito-borne diseases and control
- Food Safety and Hygiene
- Clostridium difficile and Clostridium perfringens research
- COVID-19 epidemiological studies
- Yeasts and Rust Fungi Studies
- Zoonotic diseases and public health
- Viral Infections and Outbreaks Research
- Plant Pathogens and Fungal Diseases
- Blood donation and transfusion practices
- Viral Infections and Vectors
- Plant Pathogens and Resistance
- Blood transfusion and management
- Travel-related health issues
- Listeria monocytogenes in Food Safety
- Parasitic Infections and Diagnostics
- Child Nutrition and Water Access
- Primary Care and Health Outcomes
- Substance Abuse Treatment and Outcomes
BC Centre for Disease Control
2007-2025
Public Health Agency of Canada
2005-2022
University of North Carolina Hospitals
2018
Engineering Associates (United States)
2018
University of Ottawa
2002-2014
University of Toronto
2002-2014
Cancer Care Ontario
2012-2014
IT for Change
2014
University Health Network
2014
Queen's University
2014
Cryptococcus gattii causes life-threatening infection of the pulmonary and central nervous systems in hosts with normal immunity traditionally has been considered to be restricted geographically tropical subtropical climates. The recent outbreak C. temperate climate Vancouver Island, BC, Canada, led a collaborative investigation. objectives current study were ascertain environmental source infections, survey molecular types cryptococcal isolates, determine extent genetic diversity among...
British Columbia, Canada, has the largest reported population of Cryptococcus gattii-infected persons worldwide. To assess impact illness, we retrospectively analyzed demographic and clinical features cases, hospitalizations, deaths during 1999-2007. A total 218 cases were (average annual incidence 5.8 per million persons). Most who sought treatment had respiratory illness (76.6%) or lung cryptococcoma (75.4%). Persons without HIV/AIDS hospitalized with cryptococcosis more likely than those...
The province of British Columbia (BC) Canada has experienced a rapid increase in illicit drug overdoses and deaths during the last 4 years, with provincial emergency declared April 2016. These have been driven primarily by introduction synthetic opioids into opioid supply. This study aimed to measure combined impact large-scale overdose interventions implemented BC between 2016 December 2017 on number averted.We expanded mathematical modelling methodology our previous construct Bayesian...
Abstract Cryptococcus gattii, emergent on Vancouver Island, British Columbia (BC), Canada, in 1999, was detected during 2003–2005 3 persons and 8 animals that did not travel to Island the incubation period; positive environmental samples were areas outside Island. All clinical isolates found BC genotypically consistent with strains. In addition, local acquisition cats Washington 2 Oregon. The molecular profiles of Oregon differed from those Washington. Although some microclimates Pacific...
Abstract To determine whether particular environmental, medical, or behavioral risk factors existed among Cryptcoccus gattii–infected persons compared with the general population, we conducted a sex-matched case−control study on subset of case-patients in British Columbia (1999–2001). Exposures and underlying medical conditions all (1999–2007) were also results provincial population–based surveys studies. In analyses, oral steroids (matched odds ratio [MOR] 8.11, 95% confidence interval [CI]...
Abstract Recent Cryptococcus gattii infections in humans and animals without travel history to Vancouver Island, as well environmental isolations of the organism other areas Pacific Northwest, led an investigation potential dispersal mechanisms. Longitudinal analysis C. presence trees soil showed patterns permanent, intermittent, transient colonization, reflecting population dynamics once pathogen is introduced a new site. Systematic sampling was associated with high-traffic locations. In...
Abstract A total of 184 methicillin-resistant Staphylococcus aureus (MRSA) strains were collected from patients who sought treatment primarily for skin and soft tissue infections January 1, 1999, to March 31, 2002, in east-central Saskatchewan, Canada. Molecular subtyping analysis using pulsed-field gel electrophoresis showed 2 major clusters. Cluster (n = 55) was composed a multidrug-resistant MRSA strain associated with long-term care facility similar the previously reported nosocomial...
A multi-province outbreak of listeriosis occurred in Canada from June to November 2008. Fifty-seven persons were infected with 1 3 similar strains defined by pulsed-field gel electrophoresis, and 24 (42%) individuals died. Forty-one (72%) 57 residents long-term care facilities or hospital inpatients during their exposure period. Descriptive epidemiology, product traceback, detection the Listeria monocytogenes food samples plant environment confirmed delicatessen meat manufactured one...
Cryptococcus gattii emerged in 1999 a distinct ecologic environment on Vancouver Island, Canada. Estimates of incubation period were derived from an analysis travelers with discreet exposures to this region. Individual case periods ranged 2 11 months, median 6 7 months.
To improve symptom management, the Ontario Cancer Symptom Management Collaborative uses common assessment and care management tools including Interactive Assessment Collection, which allows patients to report their symptoms via kiosks or tablets directly clinicians in real-time.
Abstract Background. Cryptococcus gattii (Cg) infection emerged in British Columbia 1999. A longitudinal, clinical description of patients has not been reported. Methods. Medical records were reviewed for Cg identified through surveillance (1999–2007). Risk factors mortality explored using multivariate Cox regression; longitudinal patterns serum cryptococcal antigen (SCrAg) titers and the probability chest cryptococcomas over time estimated cubic B-splines mixed-effects regression models....
British Columbia (BC), Canada declared a public health emergency in April 2016 for opioid overdose. Comprehensive data was needed to identify risk factors, inform interventions, and evaluate response actions. We describe the development of an overdose cohort, including linkage strategy, case definitions, governance model, present resulting characteristics, yields overlap among sources.Overdose events from hospital admissions, physician visits, poison centre ambulance calls, department...
Abstract Background Cryptococcosis due to Cryptococcus neoformans and gattii varies with geographic region, populations affected, disease manifestations, severity of infection, which impact treatment. Methods We developed a retrospective cohort patients diagnosed culture-proven cryptococcosis during 1995–2013 from 5 centers in North America Australia. compared underlying diseases, clinical treatment, outcomes C. or infection. Results A total 709 (452 neoformans; 257 gattii) were identified....
A case-control study was conducted from 1 January to 31 May 2003 identify risk factors for S . Heidelberg infection in Canada. Controls were pair-matched by age group and telephone exchange 95 cases. Exposures the 7 days before illness/interview assessed using multivariate conditional logistic regression. Consumption of home-prepared chicken nuggets and/or strips [matched odds ratio (mOR) 4.0, 95% confidence interval (CI) 1.4-13.8], undercooked eggs (mOR 7.5, CI 1.5-75.5) increased illness....
In developed countries, gastrointestinal illness (GI) is typically mild and self-limiting, however, it has considerable economic impact due to high morbidity. The magnitude distribution of acute GI in British Columbia (BC), Canada was evaluated via a cross-sectional telephone survey 4,612 randomly selected residents, conducted from June 2002 2003. Respondents were asked if they had experienced vomiting or diarrhoea the 28 days prior interview. A response rate 44.3% achieved. monthly...
Under-reporting of infectious gastrointestinal illness (IGI) in British Columbia, Canada was calculated using simulation modelling, accounting for the uncertainty and variability input parameters. Factors affecting under-reporting were assessed during a cross-sectional randomized telephone survey. For every case IGI reported to province, mean 347 community cases occurred (5th 95th percentile estimates ranged from 181 611 cases, respectively). Vomiting [odds ratio (OR) 2.15, 95% confidence...
Objectives: In January 2004, an increase in gastrointestinal illness following oyster consumption was reported British Columbia. An investigation initiated to explore the association between norovirus infection and of Columbia oysters identify source contamination. Methods: The outbreak included active surveillance for human cases, two cohort studies, trace-back oysters, laboratory testing stools. Results: Enhanced identified 26 confirmed 53 clinical cases over 3 months. Oyster associated...
Abstract Background Infection by Cryptococcus gattii can lead to pulmonary or central nervous system (CNS) disease, both. Whether site of infection and disease severity are associated with C. species lineages certain underlying medical conditions, both is unclear. We conducted a retrospective cohort study identify factors mortality among cases. Methods extracted data on 258 cases from Australia, Canada the United States reported 1999 2011. unadjusted multivariable logistic regression...