A5078503330- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Obstructive Sleep Apnea Research
- Mosquito-borne diseases and control
- Neuroscience of respiration and sleep
- Virology and Viral Diseases
- Maternal and fetal healthcare
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Anesthesia and Pain Management
- Global Maternal and Child Health
- Maternal and Perinatal Health Interventions
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Viral Infections and Vectors
- Gut microbiota and health
- Maternal Mental Health During Pregnancy and Postpartum
- Sleep and related disorders
- Neonatal and fetal brain pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Infant Nutrition and Health
- Prenatal Substance Exposure Effects
- Pregnancy-related medical research
- COVID-19 Impact on Reproduction
University of Wisconsin–Madison
2016-2025
Baylor College of Medicine
2014-2024
Texas Children's Hospital
2014-2024
University of Auckland
2024
Madison Group (United States)
2023
Thomas Jefferson University
2021
Northeast Ohio Medical University
2021
University of Atlanta
2021
University of South Carolina
2021
University of Alabama at Birmingham
2021
Metagenomic approaches demonstrate that the human placenta is not sterile but harbors a unique microbiome.
Emerging evidence suggests that the in utero environment is not sterile as once presumed. Work mouse demonstrated transmission of commensal bacteria from mother to fetus during gestation, though it unclear what modulates this process. We have previously shown nonhuman primate that, independent obesity, a maternal high-fat diet gestation and lactation persistently shapes juvenile gut microbiome. therefore sought interrogate population-based human longitudinal cohort whether similarly alters...
Infection with Zika virus (ZIKV) is associated human congenital fetal anomalies. To model outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals a previous study contemporary the current report clear viremia within 10–12 days, maternal was prolonged 3 of 4 pregnancies. Fetal head growth velocity last month gestation determined by ultrasound assessment circumference decreased comparison biparietal diameter...
Congenital Zika virus (ZIKV) infection impacts fetal development and pregnancy outcomes. We infected a pregnant rhesus macaque with Puerto Rican ZIKV isolate in the first trimester. The was complicated by preterm premature rupture of membranes (PPROM), intraamniotic bacterial demise 49 days post (gestational day 95). Significant pathology at maternal-fetal interface included acute chorioamnionitis, placental infarcts, leukocytoclastic vasculitis myometrial radial arteries. RNA disseminated...
We employed accepted, validated symptom-based screening measures to discern attributable risk of obstructive sleep apnea (OSA) adverse pregnancy outcomes, taking into account potential maternal confounders. Commonly OSA (Berlin and Epworth scales) were performed in the second third trimesters; neonatal outcome data thereafter obtained. The relationship between outcomes interest explored stratified multivariate models controlling for overall prevalence was 25.4%. Given a nonlinear increase by...
Obesity is associated with alterations in thyroid hormone (TH) levels obese, pregnant individuals. The maintenance of TH throughout gestation important for proper foetal development. aim this study was to measure fT3, fT4 and TSH maternal matched cord blood serum from normal weight, overweight obese gravidae determine neonatal by virtue obesity.ELISA utilized banked, (cord blood) (N = 205 pairs). Data were stratified according prepregnancy or first trimester BMI.Both fT3 consistently...
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV- animals, infection early first trimester caused...
ZIKV was first identified in 1947 Africa, but most of our knowledge is based on studies the distinct Asian genetic lineage, which caused outbreak Americas 2015 to 2016. In its recent update, WHO stated that improved understanding African-lineage pathogenesis during pregnancy must be a priority.
Abstract Background Stigma and bias experienced during prenatal care can affect quality of and, ultimately, the health pregnant women with obesity their infants. We sought to 1) better understand stigma that BMIs ≥40 kg/m 2 experience while receiving care, 2) gauge women’s interest in group education for obesity, 3) gather feedback about preferred weight-related terminology. Methods conducted thematically content-analyzed 30 semi-structured interviews who received at a university-affiliated...
Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika (ZIKV) disease, due the homology between ZIKV and DENV observation of antibody-dependent enhancement (ADE) among serotypes. To date, no study has examined impact on pathogenesis during pregnancy in a translational non-human primate model. Here we show macaques with prior DENV-2 exposure had higher burden vRNA maternal-fetal interface tissues as compared DENV-naive macaques. However, detectable...
Introduction: Measures of maternal fractional blood volume (mFBV) in the placenta holds potential to diagnose placental vasculature deficiencies. However, methods for quantitative mapping are challenging implement clinical evaluation. As a preliminary step towards human applications, this study assesses feasibility measurements using ferumoxytol enhanced variable flip angle (VFA) T1-mapping Zika-infected rhesus macaques. Methods: Seven pregnant macaques were imaged longitudinally at up 3...
<b>Objective</b> The diagnosis of coagulopathy cannot always be performed at point care. Thromboelastography (TEG) and the platelet-function analyzer (PFA-100), have emerged as reliable means for coagulation analysis. However, their utility in pregnancy remains to determined. We sought establish reference values with concomitant determination other known measures nonlaboring gravidae an effort report mean variance multiple testing modalities. <b>Study Design</b> Fifty-nine term, nonlaboring,...
Objective To evaluate nutrition-only, exercise-only, and nutrition-plus-exercise interventions for optimizing gestational weight gain (GWG) based on the 2009 Institute of Medicine (IOM) guidelines. Study PubMed, Google Scholar, 2015 Cochrane Review were searched. Analysis variance was used to determine if significant GWG differences exist between strategies, with additional subanalyses overweight (OV) or obese women IOM Results Of 66 identified studies, 31 contributed data (n = 8,558)....
Severe infection with COVID-19 virus in pregnancy offers unique management challenges for the obstetrician and critical care specialist. We report case of a woman at 26 weeks gestation acute respiratory distress syndrome secondary to treated dexamethasone, remdesivir, convalescent plasma mechanical ventilation. Cesarean delivery was performed 29 due worsening maternal status. This insight into assessment successful use treatment strategies, including plasma, early prone positioning,...