Amy Hartman
A5080884495- Mosquito-borne diseases and control
- HIV/AIDS Research and Interventions
- Neonatal and fetal brain pathology
- COVID-19 Impact on Reproduction
- Chemical Reactions and Isotopes
- Autism Spectrum Disorder Research
- Global Maternal and Child Health
University of Wisconsin–Madison
2019-2023
Madison Group (United States)
2023
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV- animals, infection early first trimester caused...
Congenital Zika virus (ZIKV) exposure results in a spectrum of disease ranging from severe birth defects to delayed onset neurodevelopmental deficits. ZIKV-related neuropathogenesis, predictors defects, and deficits are not well defined people. Here we assess the methodological statistical feasibility congenital ZIKV macaque model for identifying infant neurobehavior brain abnormalities that may underlie We inoculated five pregnant macaques with mock-inoculated one first trimester. Following...
Abstract In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV-animals, infection early first trimester...
Abstract Background In utero Zika virus (ZIKV) infection causes birth defects and neurodevelopmental deficits in neonates. We reasoned that a translational macaque model of congenital ZIKV could define disease pathophysiology not possible human clinical studies. Methods inoculated 5 pregnant rhesus macaques with Puerto Rican isolate (ZIKV-PRVABC59) during the first trimester, monitored plasma viral RNA (vRNA) loads, evaluated infants for their week life. Assessments included neurobehavioral...
Abstract Congenital Zika virus (ZIKV) exposure results in a spectrum of disease ranging from severe birth defects to delayed onset neurodevelopmental deficits. ZIKV-related neuropathogenesis, predictors defects, and deficits are not well defined people. Here we assess the methodological statistical feasibility congenital ZIKV macaque model for identifying infant neurobehavior brain abnormalities that may underlie We inoculated five pregnant macaques with mock-inoculated one first trimester....