A5038573286- Genetics, Aging, and Longevity in Model Organisms
- Selenium in Biological Systems
- Diet, Metabolism, and Disease
- Circadian rhythm and melatonin
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diabetes and associated disorders
- Advanced Glycation End Products research
- Prion Diseases and Protein Misfolding
- Birth, Development, and Health
- Parasites and Host Interactions
- Immune Cell Function and Interaction
- Coenzyme Q10 studies and effects
- Tryptophan and brain disorders
- Biochemical Acid Research Studies
- Trace Elements in Health
- Aluminum toxicity and tolerance in plants and animals
- Alcohol Consumption and Health Effects
- Microbial metabolism and enzyme function
- Moringa oleifera research and applications
- Cancer, Hypoxia, and Metabolism
Friedrich Schiller University Jena
2014-2024
Abstract D -Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism activates AMP-activated protein kinase (AMPK/AAK-2) increases mitochondrial biogenesis. Consistent with concept mitohormesis, GlcN promotes increased formation reactive oxygen...
Human selenium-binding protein 1 (SELENBP1) was originally identified as a binding selenium, most likely selenite. SELENBP1 is associated with cellular redox and thiol homeostasis in several respects, including its established role methanethiol oxidase that involved degradation of methanethiol, methionine catabolite, generating hydrogen sulfide (H2S) peroxide (H2O2). As both H2S reactive oxygen species (such H2O2) are major regulators Caenorhabditis elegans lifespan stress resistance, we...
Methanethiol is a toxic gas produced through bacterial degradation of sulfur-containing amino acids. Applying novel enzymatic assay, we here identified methanethiol oxidase (MTO) that catalyzes the in nematode Caenorhabditis elegans (C. elegans). The corresponding protein, Y37A1B.5, previously characterized as C. ortholog human selenium-binding protein 1 (SELENBP1), was renamed SEMO-1 (SELENBP1 with activity). Worms rendered deficient not only showed decreased hydrogen sulfide production...
Scope The role of invariant natural killer T cells in the development nonalcoholic steatohepatitis (NASH) has not yet been fully understood. Here, effect T‐cell activator alpha‐galactosylceramide (αGalCer) on fatty liver disease and intestinal barrier function was assessed a mouse model early Western‐style diet (WSD) induced NASH. Methods results Female C57BL/6J mice were either fed liquid control or fructose‐enriched WSD for 6 wk while being treated three times weekly with αGalCer (2 μg...
Selenium (Se) is an essential trace element for humans and animals, but high-dose supplementation with Se compounds, most notably selenite, may exert cytotoxic other adverse effects. On the hand, bacteria, including Escherichia coli (E. coli), are capable of reducing selenite to red elemental that serve as a safer source. Here, we examined how diet Se-enriched E. bacteria affected vital parameters age-associated neurodegeneration in model organism Caenorhabditis elegans (C. elegans). The...
Die Aufnahme von Fruktose ist in vielen industrialisierten Ländern weltweit den letzten Jahrzehnten stark angestiegen. Dies resultiert u. a. aus einer zunehmenden Verwendung des reinen Monosaccharids oder sog. <i>„High Fructose Corn Syrup“</i> (HFCS, Maissirup auch Fruktose-Glukose-Sirup) als Süßungsmittel. Neben Problemen für Patienten mit angeborenen erworbenen Fruktosemalabsorption sowie der seltenen, genetisch bedingten hereditären Fruktoseintoleranz, wird die vermehrte industrielle und...