A5040069444- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Immune cells in cancer
- Clinical Nutrition and Gastroenterology
- Vitamin D Research Studies
- Liver Diseases and Immunity
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Enhanced Recovery After Surgery
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Fibroblast Growth Factor Research
- Muscle metabolism and nutrition
- Gastrointestinal motility and disorders
- Alcohol Consumption and Health Effects
- Pharmacological Effects and Toxicity Studies
- Complementary and Alternative Medicine Studies
- Hormonal Regulation and Hypertension
- Endometriosis Research and Treatment
Martin Luther University Halle-Wittenberg
2022-2024
University of Vienna
2017-2023
Friedrich Schiller University Jena
2016-2020
University of Lübeck
2011
University Hospital Schleswig-Holstein
2011
There is a striking association between human cholestatic liver disease (CLD) and inflammatory bowel disease. However, the functional implications for intestinal microbiota inflammasome-mediated innate immune response in CLD remain elusive. Here we investigated role of gut-liver crosstalk murine Mdr2 knockout (Mdr2-/-) model resembling primary sclerosing cholangitis (PSC).Male Mdr2-/-, Mdr2-/- crossed with hepatocyte-specific deletion caspase-8 (Mdr2-/- /Casp8∆hepa) wild-type (WT) control...
Abstract The antidiabetic drug metformin has been proposed to affect non-alcoholic fatty liver disease (NAFLD) through its effects on intestinal microbiota and barrier function. However, so far most studies focused long-term more progressed stages. aim of this study was assess in two experimental settings, if the onset NAFLD is associated with changes function determine herein. C57Bl/6J mice were fed a liquid control diet (C) or fat-, fructose- cholesterol-rich (FFC) for four days six weeks...
Acute liver failure (ALF) represents an unmet medical need in Western countries. Although the link between intestinal dysbiosis and chronic disease is well-established, there little evidence for a functional role of gut-liver interaction during ALF. Here we hypothesized that may affect
Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via butyrate production. Human bariatric surgery data suggest the gut-brain axis is also involved this process, but underlying mechanisms remain unknown.We compared effect of fecal transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin (SERT) binding as well stable isotope-determined...
Recent studies have shown that patients with manifest non-alcoholic fatty liver disease (NAFLD), e.g. steatosis grade 3 or steatohepatitis without beginning fibrosis frequently show altered fecal microbiota composition and elevated bacterial endotoxin levels. However, if these alterations are signs of a progressing already found in initial stages has not yet been clarified.Twenty children simple (grade 1) diagnosed by ultrasound 29 normal weight healthy control (age <10 years) were included...
The role of nutrition and diet in the development non-alcoholic fatty liver disease (NAFLD) is still not fully understood. In present study, we determined if dietary pattern markers intestinal permeability differ between overweight children with without NAFLD. addition, a feasibility assessed effect moderate intervention only focusing on nutrients identified to groups barrier function health status. Anthropometric data, intake, metabolic parameters, inflammation, as well permeability, were...
(1) Background: The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect severity. aim this study was to evaluate dietary intake markers permeability in patients with NAFLD. (2) Methods: We enrolled 63 NAFLD compared them age-matched controls. (3) Results: body mass index (BMI) leptin adiponectin ratio—the latter being an indicator abdominal fat accumulation—correlated the...
Aging is considered a state of low grade inflammation, occurring in the absence any overt infection often referred to as 'inflammaging'. Maintaining intestinal homeostasis may be target extend healthier status older adults. Here, we report that even healthy men bacterial endotoxemia prevalent. In addition, employing multiple mouse models, also show while microbiota composition changes significantly during aging, fecal transplantation old mice does not protect against aging-associated barrier...
Serum vitamin D levels negatively correlate with obesity and associated disorders such as non-alcoholic steatohepatitis (NASH). However, the mechanisms linking low (VD) status to disease progression are not completely understood. In this study, we analyzed effect of VD treatment on NASH in mice. C57BL6/J mice were fed a high-fat/high-sugar diet (HFSD) containing amounts for 16 weeks induce obesity, liver fibrosis. The effects preventive interventional studied level histology...
Sodium butyrate (SoB) supplementation has been suggested to attenuate the development of non-alcoholic fatty liver disease (NAFLD). Here, we determined therapeutic potential SoB on NAFLD progression and molecular mechanism involved. Eight-week old C57BL/6J mice were pair-fed a fat-, fructose- cholesterol-rich diet (FFC) or control (C). After 8 weeks, some received 0.6g SoB/kg bw in their respective diets (C+SoB; FFC+SoB) maintained C FFC for next 5 weeks feeding. Liver damage, markers...
Changes in intestinal nitric oxide metabolism are discussed to contribute for the development of barrier dysfunction non-alcoholic fatty liver disease (NAFLD). To induce steatosis, female C57BL/6J mice were pair-fed with a liquid control diet (C) or fat-, fructose- and cholesterol-rich (FFC) 8 weeks. Mice received diets ± 2.49 g L-arginine/kg bw/day additional 5 Furthermore, fed C FFC weeks concomitantly treated arginase inhibitor Nω -hydroxy-nor-L-arginine (nor-NOHA, 0.01 g/kg bw). Liver...
Dietary arginine (Arg) supplementation has been proposed to have positive effects on the development of liver diseases. In present study, we investigate if an oral Arg in diet protects mice fed a fructose, fat and cholesterol enriched Western-style (WSD) from non-alcoholic steatohepatitis (NASH). Female C57BL/6J were liquid control or WSD ± (2.49 g/kg body weight/day) for 6 weeks. Indices injury, glucose metabolism intestinal permeability determined. While had no weight gain, fasting blood...
Dietary pattern and impairments of intestinal barrier function are discussed to be critical in the development metabolic impairments. Here, it is determined if an isocaloric exchange complex carbohydrates with monosaccharides affects markers permeability health healthy subjects.
Aging is a risk factor in the development of many diseases, including liver-related diseases. The two aims present study were 1) to determine how aging affects liver health mice absence any interventions and 2) if degenerations observed relation blood endotoxin levels are critical aging-associated degeneration. Endotoxin markers damage, mitochondrial dysfunction, insulin resistance, apoptosis as well Toll-like receptor 4 (Tlr-4) signaling cascade studied tissue blood, respectively, 3-...
Non-alcoholic fatty liver disease (NAFLD) is by now the most prevalent worldwide. The non-proteogenic amino acid l-citrulline (L-Cit) has been shown to protect mice from development of NAFLD. Here, we aimed further assess if L-Cit also attenuates progression a pre-existing diet-induced NAFLD and determine molecular mechanisms involved. Female C57BL/6J were either fed liquid fat-, fructose- cholesterol-rich diet (FFC) or control (C) for 8 weeks induce early stages NASH followed 5 more with...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases worldwide lacking universally accepted therapies. Studies suggest that coffee consumption associated with a reduced risk NAFLD; however, molecular mechanisms and ingredients involved remain to be fully understood. Here, we determined effects regular intake decaffeinated on development NAFLD in mice, involved. Female C57BL/6J mice (n = 6–7/ group) were pair-fed either liquid control diet (C) or fat-, fructose-...
Abstract Toll-like receptors (TLRs) in the liver compartment have repeatedly been attributed to development of non-alcoholic fatty disease (NAFLD). Knowledge on TLR expression blood cells and their relation intestinal microbiota NAFLD is limited. Here, we determined patterns peripheral mononuclear (PBMCs) patients controls, impact TLRs found altered development. Markers permeability mRNA PBMCs were 37 15 age-matched healthy controls. Fecal composition was evaluated 21 9 controls using 16S...
The number of people above the age 60 years is raising world-wide being associated with an increase in prevalence aging-associated impairments and even diseases. Recent studies suggest that aging alterations bacterial endotoxin levels these changes may add to low-grade inflammation, so-called 'inflammaging', liver degeneration. However, mechanisms involved, especially, interaction intestinal microbiota barrier development inflammation degeneration have not been fully understood. aim present...
Being overweight has been identified as the main risk factor for development of metabolic disorders in adults and children. However, recent studies suggest that normal weight individuals are also frequently affected by abnormalities with underlying mechanisms not yet fully understood. The aim present study was to determine if dietary pattern markers intestinal permeability, well inflammation, differ between healthy children suffering from abnormalities. In total, 45 aged 5–9 years were...
Absolute dietary fat intake but even more so fatty acid pattern is discussed to be critical in the development of non-alcoholic liver disease (NAFLD). Here, we determined if switching a butterfat enriched diet rapeseed oil (RO) affects progression an existing NAFLD and glucose intolerance mice.For eight weeks, female C57Bl/6J mice were either fed liquid control (C) or butterfat-, fructose- cholesterol-rich (BFC, 25E% butterfat) induce early signs steatohepatitis mice. For additional five...
Dietary fat is discussed to be critical in the development of non-alcoholic fatty liver disease. Here, we assess effect exchanging dietary source from butterfat extra virgin olive oil on progression an already existing diet-induced disease mice. Female C57BL/6J mice were fed a liquid butterfat-, fructose- and cholesterol-rich diet (BFC, 25E% butterfat) or control (C, 12%E soybean oil) for 13 weeks. In week 9, sources some BFC- C-fed switched either 12E% (OFC CO). Glucose insulin tolerance...
Abstract Purpose The consumption of highly processed food is often associated with a high intake inorganic phosphate. Hyperphosphatemia accompanied by an inflammatory status in patients chronic kidney disease. However, the immune response to phosphorus healthy individuals largely unknown. Therefore, aim present study was evaluate effect single phosphate-enriched meal on inflammasome activity and plasma levels markers. Methods analysis included 28 participants who received dose either 700 mg...