A5016520701- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Liver Diseases and Immunity
- Gastroesophageal reflux and treatments
- Hepatitis Viruses Studies and Epidemiology
- Nutrition and Health in Aging
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Frailty in Older Adults
- Inflammatory Bowel Disease
- Pancreatitis Pathology and Treatment
- Alcohol Consumption and Health Effects
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Renal function and acid-base balance
- HIV-related health complications and treatments
- Gastrointestinal motility and disorders
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- Autoimmune and Inflammatory Disorders
- Microscopic Colitis
- Palliative Care and End-of-Life Issues
Johannes Gutenberg University Mainz
2016-2025
University Medical Center of the Johannes Gutenberg University Mainz
2016-2025
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2016-2025
University of Michigan–Ann Arbor
2024
University Hospital of Zurich
2016
University of Zurich
2016
Essen University Hospital
2015-2016
Professional Services Group (United States)
1997
Summary Background Advanced fibrosis has been established as the most important predictor of overall mortality in patients with non‐alcoholic fatty liver disease ( NAFLD ). In contrast to cirrhosis, advanced, non‐cirrhotic is difficult identify and data from Germany are lacking. Aim To clinical factors associated fibrosis. Methods Patients were recruited prospectively enrolling European Registry. Clinical characteristics performance non‐invasive surrogate scores compared vibration‐controlled...
Nonalcoholic fatty liver disease (NAFLD), depression, and anxiety disorders are frequent diseases, data on mutual influence inconsistent. The aim of this study was to explore the incidence depression in a large primary care cohort Germany impact NAFLD over 10-year time frame. Patients with diagnosed between 2010 2015 were matched without controlling for age, sex, physician, index year, Charlson comorbidity index. outcome anxiety, first prescription antidepressant drugs. We compared 19,871...
Minimal hepatic encephalopathy (HE) and HE grade 1 (HE1) according to the West Haven criteria have recently been grouped as one entity named-covert HE- (CHE). Data regarding impact of CHE on health-related quality life (HRQoL) sleep are controversial.First, determine whether affects HRQoL cirrhotic patients second, minimal (MHE) HE1 affect a comparable extent.A total 145 consecutive were enrolled. was diagnosed clinically criteria. Critical flicker frequency Psychometric Hepatic...
Summary Background Lifestyle modifications remain the cornerstone of treatment in non‐alcoholic fatty liver disease (NAFLD). However, they requently fail related to inability patients implement lasting changes. Aims To evaluate effects a short, web‐based, individualised exercise program on non‐invasive markers hepatic steatosis, inflammation and fibrosis. Methods Patients with histologically confirmed NAFLD underwent an 8‐week, that contained bidirectional feedback. Results Forty‐four...
The prevalence of minimal hepatic encephalopathy (MHE), in particular different subgroups, remains unknown. This study aimed to analyze the MHE subgroups identify patients at high risk and pave way for personalized screening approaches.In this study, data recruited 10 centers across Europe United States were analyzed. Only without clinical signs included. was detected using Psychometric Hepatic Encephalopathy Score (PHES, cut-off < or ≤-4 depending on local norms). Clinical demographic...
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic disease. Its role in the development of extrahepatic co-morbidities under investigation. The impact NAFLD on kidney (CKD) incompletely understood. aim this study was to explore potential contribution CKD Germany.The Disease Analyzer Database covering 7.49 million cases Germany explored for patients diagnosed with between 2000 and 2015 matched 1:1 cohort without NAFLD. Matching criteria included age, sex, physician, index...
Summary Background The current management of metabolic dysfunction‐associated steatotic liver disease (MASLD) relies on lifestyle intervention. Prior studies have shown that nutritional wheat amylase trypsin inhibitors (ATI) activate toll‐like receptor 4 intestinal myeloid cells to enhance and extra‐intestinal inflammation, including the promotion murine MASLD, insulin resistance fibrosis. Aims We aimed assess impact ATI (gluten)‐free diet in as well parameters biopsy‐proven MASLD patients....
Type 2 diabetes mellitus (T2DM) is a major risk factor for advanced liver disease. The aim of this prospective cohort study was to assess the prevalence and associated factors fibrosis cirrhosis in primary care centers participating disease management program (DMP) Germany.
Systemic inflammation is a driving force for the development of hepatic encephalopathy and recent studies demonstrated that elevated Interleukin-6 (IL-6) serum levels are associated with presence minimal in patients liver cirrhosis.To test hypothesis IL-6 suitable marker to identify cirrhosis at high risk overt encephalopathy.201 were included into this prospective cohort study followed mean time 322 days. Covert was diagnosed according West-Haven criteria (hepatic grade 1) portosystemic...
(1) Background: The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect severity. aim this study was to evaluate dietary intake markers permeability in patients with NAFLD. (2) Methods: We enrolled 63 NAFLD compared them age-matched controls. (3) Results: body mass index (BMI) leptin adiponectin ratio—the latter being an indicator abdominal fat accumulation—correlated the...
Diagnosis of minimal hepatic encephalopathy (MHE) requires psychometric testing, which is time-consuming and often neglected in clinical practice. Elevated Interleukin-6 (IL-6) serum levels have been linked to MHE. The aim this study was investigate the usefulness IL-6 as a biomarker stepwise diagnostic algorithm detect MHE patients with liver cirrhosis. A total 197 prospectively recruited without signs (HE) served development cohort. Another independent cohort consisting 52 for validation...
Abstract Background and aims Minimal hepatic encephalopathy (MHE) is a frequent complication in patients with liver cirrhosis. Its impact on predicting the development of overt (OHE) survival has not been studied large multicenter studies. Methods Data from recruited at eight centers across Europe United States were analyzed. MHE was detected using psychometric score (PHES). A subset also tested simplified animal naming test (S‐ANT1). Patients followed for OHE death/liver transplantation...
Background & AimsData on the association between proton pump inhibitor (PPI) use and hepatic encephalopathy (HE) are conflicting, data from multicenter studies scarce. The aim of this study was to dissect potential PPI minimal (MHE) overt HE (OHE).MethodsData patients with cirrhosis recruited at seven centers across Europe US were analyzed. MHE defined by Psychometric Hepatic Encephalopathy Score (PHES). recorded day testing PHES. Patients followed for OHE development death/liver...
The Freiburg Index of Post-TIPS Survival (FIPS) defines a high-risk group patients with significantly reduced survival following transjugular intrahepatic portosystemic shunt (TIPS) implantation. However, the clinical hallmarks responsible for these patients' unfavorable outcome remain to be identified. Therefore, present study aimed characterize course after TIPS implantation according FIPS. A total 1359 cirrhosis allocated treatment recurrent or refractory ascites secondary prophylaxis...
Introduction and objectives Diabetes mellitus is a common comorbidity in patients with cirrhosis associated the development of hepatic encephalopathy (HE) cognitive dysfunction. The simplified Animal Naming Test (S-ANT1) has been established for detecting minimal HE (MHE). It currently unknown whether S-ANT1 results are affected by diabetes without cirrhosis. Materials methods This study analyzed data from 268 signs ≥ 1. MHE was defined using psychometric score (PHES). All were also tested...