A5072206821- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis Viruses Studies and Epidemiology
- Bacterial Genetics and Biotechnology
- Renal cell carcinoma treatment
- Bacteriophages and microbial interactions
- Congenital Heart Disease Studies
- Pancreatic and Hepatic Oncology Research
- Gastroesophageal reflux and treatments
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- Neurogenesis and neuroplasticity mechanisms
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- Abdominal vascular conditions and treatments
- Ultrasound in Clinical Applications
- Enzyme function and inhibition
- Venous Thromboembolism Diagnosis and Management
- FOXO transcription factor regulation
- Nosocomial Infections in ICU
- Sulfur Compounds in Biology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Respiratory Support and Mechanisms
University Medical Center Freiburg
2018-2025
University of Freiburg
2011-2025
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2012
Protein insertion into the bacterial inner membrane is facilitated by SecYEG or YidC. Although most likely constitutes major integration site, small proteins have been shown to integrate via We show that YidC can also multispanning such as mannitol permease TatC, which had considered be exclusively integrated SecYEG. Only SecA-dependent strictly require for integration, suggests SecA only interact with translocon, but not insertase. Targeting of mediated signal recognition particle (SRP),...
In December 2019, several cases of pneumonia unknown origin have been reported in China, and later, SARS-CoV2 was identified as the causative pathogen for coronavirus disease 2019 (COVID-19) [1. some COVID-19, clinical courses are more severe may be aggravated by secondary infections development an acute respiratory distress syndrome (ARDS) with a high morbidity mortality However, risk factors including patients' medication poorly described. Proton pump inhibitors (PPI) play important role...
Signal recognition particle (SRP)-dependent protein targeting is a universally conserved process that delivers proteins to the bacterial cytoplasmic membrane or endoplasmic reticulum in eukaryotes. Crucial during transfer of ribosome-nascent chain complex (RNC) from SRP Sec translocon. In eukaryotes, this step co-ordinated by SRβ subunit receptor (SR), which probably senses vacant translocon direct interaction with Bacteria lack and how they co-ordinate RNC unknown. By site-directed...
To evaluate medical versus interventional treatment (transjugular thrombus fragmentation, local thrombolysis with or without stent implantation) in patients acute non-cirrhotic, non-malignant portal vein thrombosis (PVT).This prospective, observational study enrolled 65 (<28 days since begin of symptoms, no cavernoma) PVT nine centres. Thirty received and 35 treatment. was graded into grade 1: short incomplete occlusion the vessel lumen 2: extended complete occlusion. Treatment response...
The Freiburg Index of Post-TIPS Survival (FIPS) defines a high-risk group patients with significantly reduced survival following transjugular intrahepatic portosystemic shunt (TIPS) implantation. However, the clinical hallmarks responsible for these patients' unfavorable outcome remain to be identified. Therefore, present study aimed characterize course after TIPS implantation according FIPS. A total 1359 cirrhosis allocated treatment recurrent or refractory ascites secondary prophylaxis...
Cotranslational protein targeting delivers proteins to the bacterial cytoplasmic membrane or eukaryotic endoplasmic reticulum membrane. The signal recognition particle (SRP) binds sequences emerging from ribosomal tunnel and targets ribosome-nascent-chain complex (RNC) SRP receptor, termed FtsY in bacteria. interacts with fifth cytosolic loop of SecY SecYEG translocon, but functional role interaction is unclear. By using photo-cross-linking fluorescence resonance energy transfer...
Protein targeting by the signal recognition particle (SRP) and bacterial SRP receptor FtsY requires a series of closely coordinated steps that monitor presence substrate, membrane, vacant translocon. Although influence substrate binding on FtsY-SRP complex formation is well documented, contribution membrane largely unknown. In current study, we found negatively charged phospholipids stimulate formation. Phospholipids act conserved positively amphipathic helix in induce conformational change...
Treatment with proton pump inhibitors (PPIs) has been associated development of hepatic encephalopathy (HE). As HE is a major complication after implantation transjugular intrahepatic portosystemic shunt (TIPS), we hypothesized that PPI treatment may be higher risk post-TIPS HE.We analyzed data 397 patients liver cirrhosis who received de novo TIPS at the University Medical Center Freiburg, Germany. We assessed whether medication and other patient characteristics are predictive factors for...
The aim of this prospective observational trial was to evaluate the efficacy, toxicity and quality life after stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC) assess results treatment comparison trans-arterial chemoembolization (TACE). Patients HCC, treated TACE or SBRT, over a period 12 months, enrolled study. primary endpoint feasibility; secondary endpoints were toxicity, (QOL), local progression (LP) overall survival (OS). Between 06/2016...
Endoscopic treatment of pancreatic necrosis can be challenging and time-consuming because sticky necrotic debris is sometimes difficult to remove. The over-the-scope-grasper, a new tool that has recently become available for this purpose, might also useful other indications. However, clinical data on the efficacy safety device are lacking.To evaluate technical success in multicenter setting.The over-the-scope-grasper was used nine selected endoscopic centers between November 2020 October...
Hepatic vein outflow obstruction causes congestion of the liver, leading to necrosis, fibrosis, and portal hypertension (PH). A transjugular intrahepatic portosystemic shunt (TIPS) reduces PH by providing artificial outflow. The aim study was investigate fibrosis progression in patients with Budd–Chiari syndrome (BCS) TIPS using transient elastography (TE). From 2010 2022, 25 received 80 TEs FibroScan®, Echosens, Paris, France (3.2 ± 2.1 per patient). function assessed via Doppler ultrasound...
Abstract Transarterial radioembolization (TARE) is a well‐established therapy for intermediate and advanced tumor stages of hepatocellular carcinoma (HCC). Treatment‐associated toxicities are rare. Previous studies have outlined that the prognosis after TARE determined primarily by stage liver function. The subset patients benefiting from remains to be defined. Sixty‐one with HCC treated between 2015 2020 were retrospectively included in study. Hepatic decompensation was defined as an...
Background Reelin is an extracellular glycoprotein involved in several functions of brain development, synaptogenesis and dendritic proliferation. Numerous studies found perturbation the reelin system altered serum levels neuropsychiatric patients using western blot procedure. In international literature, this first study that made use enzyme-linked immunosorbent assay to analyze protein concentration quantitatively. Rationale order possible alterations blood schizophrenia, we analyzed...
Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an established procedure to treat portal hypertension. Impact of administration aspirin on transplant-free survival after TIPS remains unknown. A multicenter retrospective analysis including patients with between 2011 and 2018 at three tertiary German Liver Centers was performed. N = 583 were included. Survival performed in a matched cohort propensity score matching. Patients grouped according whether (PSM-aspirin-cohort)...
Long-term prescription of proton pump inhibitors (PPIs) in patients with cirrhosis is common practice. However, recent years, several observational studies have reported increased complications and negative prognostic effects PPI treatment these patients. Judging the significance associations complicated by fact that a plausible underlying pathomechanism has not been identified so far. In present study, we address this important issue investigating impact on subclinical bacterial...
Prognostic assessment of patients with liver cirrhosis allocated for implantation a transjugular intrahepatic portosystemic shunt (TIPS) is challenging task in clinical practice. The aim our study was to assess the prognostic value CLIF‐C AD (Acute Decompensation) score TIPS implantation. Transplant‐free survival (TFS) and 3‐month mortality were reviewed 880 who received de novo treatment cirrhotic portal hypertension. compared Model End‐Stage Liver Disease (MELD) score, Child‐Pugh...