A5016637736- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Abdominal vascular conditions and treatments
- Gastroesophageal reflux and treatments
- Systemic Lupus Erythematosus Research
- Microscopic Colitis
- HIV/AIDS drug development and treatment
- Alcoholism and Thiamine Deficiency
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Chronic Lymphocytic Leukemia Research
- Coronary Interventions and Diagnostics
- Liver Diseases and Immunity
- Metabolism and Genetic Disorders
- Migraine and Headache Studies
University Hospital Bonn
2025
University Medical Center Freiburg
2015-2024
University of Freiburg
2007-2024
Praxis
2003-2020
Orthopädische Praxis
2018
University Hospital of Bern
2018
University of Bern
2018
Institute for Exercise and Environmental Medicine
2018
Praxis für Hämatologie und Onkologie
2014
IS practice
2014
Transjugular placement of an intrahepatic stent is a new technique to establish portosystemic shunt for treatment portal hypertension. A puncture needle advanced in catheter through the inferior vena cava into hepatic vein; then branch vein punctured and expandable metallic mesh implanted shunt.We attempted stent-shunt procedure 100 112 consecutive patients with variceal bleeding due cirrhosis, who were followed mean (+/- SD) 12 +/- 6 months. Of patients, 22 had Child-Pugh class C 10 treated...
Previous studies have suggested that the transjugular placement of an intrahepatic stent to establish a portosystemic shunt is effective treatment uncomplicated ascites accompanying variceal bleeding. We studied for use in patients with liver cirrhosis and refractory medical treatment.Fifty 62 consecutive (18 Child-Pugh class B disease 32 C) were treated shunt--an expandable metallic mesh placed between major branch portal vein one hepatic veins. Patients followed mean (+/- SD) 426 +/- 333...
In uncontrolled clinical studies, ursodeoxycholic acid (UDCA) had a beneficial effect on nonalcoholic steatohepatitis (NASH). However, large controlled trial using UDCA (13-15 mg/kg/day) was unable to confirm these results. Accordingly, randomized, placebo-controlled study initiated with high dose of (23-28 mg/kg/day). The allocation patients and the evaluation liver histology were performed according modified Brunt score fatty disease activity (NAS). With score, 185 histologically proven...
Patients with cirrhosis and variceal hemorrhage have a high risk of rebleeding. We performed prospective randomized trial to compare the prevention rebleeding in patients given small-diameter covered stent vs those hepatic venous pressure gradient (HVPG)-based medical therapy prophylaxis.We an open-label study (92% Child class A or B, 70% alcoholic) treated at 10 centers Germany. were assigned randomly more than 5 days after groups small transjugular intrahepatic portosystemic stent-shunt...
Refractory ascites is a frequent complication of advanced cirrhosis and associated with hepatorenal syndrome hepatic hydrothorax. Large volume paracentesis pleurodesis are regarded as first-line treatments in patients who do not respond adequately to diuretics. These treatments, however, prevent recurrence carry the risk worsening circulatory dysfunction leading syndrome. The transjugular intrahepatic portosystemic shunt (TIPS) has been proposed an alternative paracentesis. TIPS reduces rate...
I. Diagnostik des Aszites I.1. Einleitung: Ursachen I.2. Wann soll eine diagnostische Aszitespunktion durchgeführt werden? I.3. Technik, Komplikationen und Kontraindikationen der I.3.1 Sollen Gerinnungsfaktoren vor einer substituiert I.3.2 Welche zur bestehen? I.4. bei I.4.1 Untersuchungen sind obligater Bestandteil initialen Aszitespunktion? I.4.2 optionaler I.4.3 zytologischen sollen I.5. Spezifische Patienten mit bedingt durch ein Budd-Chiari-Syndrom (BCS) oder sinusoidales...
We studied the effects of diameter covered, self-expandable, nitinol stents on survival times patients with a transjugular intrahepatic portosystemic shunt (TIPS).We collected data from 185 (median age, 55 y; 30% female) who received covered stent, February 2006 through September 2010, using online multicenter German TIPS registry. were given to 107 for refractory ascites and 78 variceal bleeding. Patients at risk hepatic encephalopathy (owing advanced prior episodes) or liver failure...
BACKGROUND A portosystemic stent shunt may impair cardiac function and haemodynamics. AIMS To investigate the effects of a transjugular intrahepatic (TIPS) on pulmonary systemic circulation in patients with alcoholic cirrhosis. PATIENTS/METHODS 17 cirrhosis recent variceal bleeding were evaluated by echocardiography catheterisation splanchnic before after TIPS. The period catheter measurement was extended to nine hours patients. portal vein investigated Doppler ultrasound RESULTS Baseline...
Hepatic hydrothorax is a complication of portal hypertension secondary to ascites. In this study, we investigated retrospectively the effects transjugular intrahepatic portosystemic shunt (TIPS) on hepatic refractory diuretic treatment.Forty patients (Child-Pugh class B, 24 patients; Child-Pugh C, 16 patients) with treatment, pleurocenteses or pleurodesis were included. The TIPS implantation was successful in all patients, who then followed for +/- 14 months (range 1 day-54 months).TIPS...
To evaluate use of the transjugular intrahepatic portosystemic shunt (TIPS) as a nonsurgical approach for management Budd-Chiari syndrome (BCS).Twelve patients with fulminant (n = 2), subacute 5), or chronic 5) BCS underwent TIPS placement. Hepatic venous obstruction was demonstrated at computed tomography and color duplex sonography. confirmed histologically in all patients. Hemodynamic parameters clinical characteristics were assessed.TIPS creation successful Treatment reduced portal...
Hepatic arterial buffer response (HABR) is considered an important compensatory mechanism to maintain perfusion of the liver by hepatic vasodilation on reduction portal venous perfusion. HABR has been suggested be impaired in patients with advanced cirrhosis. In hepatopetal flow, placement a transjugular intrahepatic portosystemic shunt (TIPS) reduces Accordingly, severe cirrhosis should have after TIPS implantation. Therefore, aim this study was investigate effect as reflected changes...
Transjugular intrahepatic portosystemic shunt (TIPS) efficiently treats complications of portal hypertension. Liver and spleen stiffness might predict clinically significant This prospective study investigated liver in patients receiving TIPS regardless indication. Of 83 included patients, 16 underwent transient elastography immediately before 30 minutes after (acute group), while 67 received shear wave 1 day 7 days (chronic group) were followed further. In blood samples obtained from...
<h3>Objective</h3> This 1-year study aimed to assess low-dose budesonide therapy for maintenance of clinical remission in patients with collagenous colitis. <h3>Design</h3> A prospective, randomised, placebo-controlled beginning an 8-week open-label induction phase which histologically confirmed active colitis received (Budenofalk, 9 mg/day initially, tapered 4.5 mg/day), after 92 were randomised (mean dose mg/day; Budenofalk 3 mg capsules, two or one capsule on alternate days) placebo a...
The implantation of a transjugular intrahepatic portosystemic shunt (TIPSS) is complex angiographic procedure performed in patients with end-stage liver disease. Numerous case reports and narrative reviews have been published so far; however, studies systematically investigating procedural shunt-related complications are lacking.To investigate mortality occurring during the index hospital stay early (4-week) period after TIPSS implantation.The study includes 389 who received between 2004...
To evaluate the use of transjugular intrahepatic portosystemic shunt (TIPS) and local, low-dose thrombolysis in treatment complete, noncavernomatous portal vein occlusion.TIPS implantation recanalization was attempted seven patients with obstruction recurrent variceal bleeding. TIPS placement followed by thrombolytic therapy to restore venous blood flow. Hemodynamic effects clinical characteristics after procedure during follow-up were assessed.The trunk successful all patients. The reduced...
The purpose of this study was to determine the potential usefulness duplex sonography in grading portal hypertension.Duplex vein system and measurement pressure portosystemic gradient were performed 375 patients before placement transjugular intrahepatic shunts. Subgroups included with recent variceal bleeding (n = 296) refractory ascites without previous 79). A matched cohort 100 hypertension also examined. Differences between groups splenic diameter, flow velocity, congestion index,...