A5076756131- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Muscle metabolism and nutrition
- Nutrition, Genetics, and Disease
- Inflammatory Bowel Disease
- Exercise and Physiological Responses
- Long-Term Effects of COVID-19
- Acute Lymphoblastic Leukemia research
- Oral Health Pathology and Treatment
- Obesity, Physical Activity, Diet
- COVID-19 and Mental Health
- MRI in cancer diagnosis
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer survivorship and care
- Health and Medical Studies
- Palliative Care and End-of-Life Issues
University Medical Center Freiburg
2011-2025
University of Freiburg
2016-2025
Heart and Diabetes Center North Rhine-Westphalia
2024
Institute for Exercise and Environmental Medicine
2016-2018
Orthopädische Praxis
2018
University Hospital of Bern
2018
University of Bern
2018
King's College London
2011
Pain and Rehabilitation Medicine
2003
University Hospital Magdeburg
1999
PURPOSE: To compare the effectiveness of radio-frequency (RF) thermal ablation with that percutaneous ethanol injection (PEI) for treatment small hepatocellular carcinoma (HCC) in patients cirrhosis. MATERIALS AND METHODS: A series 102 hepatic cirrhosis and either single HCC 5 cm diameter or smaller as many three HCCs each 3 (overall number lesions, 142) randomly received RF (n = 52) PEI 50) sole first-line anticancer treatment. Mean follow-up was 22.9 months ± 9.4 (SD) group 22.4 8.6 group....
Previous studies have suggested that the transjugular placement of an intrahepatic stent to establish a portosystemic shunt is effective treatment uncomplicated ascites accompanying variceal bleeding. We studied for use in patients with liver cirrhosis and refractory medical treatment.Fifty 62 consecutive (18 Child-Pugh class B disease 32 C) were treated shunt--an expandable metallic mesh placed between major branch portal vein one hepatic veins. Patients followed mean (+/- SD) 426 +/- 333...
Background Self-reported health problems following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are common and often include relatively non-specific complaints such as fatigue, exertional dyspnoea, concentration or memory disturbance sleep problems. The long-term prognosis of post-acute sequelae COVID-19/post-COVID-19 (PCS) is unknown, data finding correlating organ dysfunction pathology with self-reported symptoms in patients non-recovery from PCS scarce. We wanted...
The ketogenic diet (KD) is a very low-carbohydrate, high-fat and adequate-protein that without limiting calories induces different metabolic adaptations, eg, increased levels of circulating ketone bodies shift to lipid metabolism. Our objective was assess the impact 6-week non-energy-restricted KD in healthy adults beyond cohorts athletes on physical performance, body composition, blood parameters.Our single arm, before-and-after comparison study consisted with previous preparation period...
Hepatic hydrothorax is a complication of portal hypertension secondary to ascites. In this study, we investigated retrospectively the effects transjugular intrahepatic portosystemic shunt (TIPS) on hepatic refractory diuretic treatment.Forty patients (Child-Pugh class B, 24 patients; Child-Pugh C, 16 patients) with treatment, pleurocenteses or pleurodesis were included. The TIPS implantation was successful in all patients, who then followed for +/- 14 months (range 1 day-54 months).TIPS...
Abstract Background The present study examines changes in body weight, fat mass, metabolic and hormonal parameters overweight obese pre- postmenopausal women who participated a weight loss intervention. Methods Seventy-two subjects were included the analysis of this single arm (premenopausal: 22 women, age 43.7 ± 6.4 years, BMI 31.0 2.4 kg/m 2 ; postmenopausal: 50 58.2 5.1 32.9 3.7 ). Weight reduction was achieved by use meal replacement fat-reduced diet. In addition, from week 6 to 24...
Diagnosis of acute intestinal GVHD (aGVHD) following allogeneic hematopoietic cell transplantation is based on clinical symptoms and histological lesions. This retrospective analysis aimed to validate the 'Freiburg Criteria' for endoscopic grading aGVHD. Grade 1: no clear-cut criteria; grade 2: spotted erythema; 3: aphthous lesions; 4: confluent defects, ulcers, denudation mucosa. Having excluded patients with infectious diarrhea, we evaluated 175 consecutive between January 2001 June 2009....
To compare time-resolved three-dimensional (3D) phase-contrast magnetic resonance (MR) imaging with three-directional velocity encoding (flow-sensitive four-dimensional [4D] MR imaging), Doppler ultrasonography (US) as standard of reference, for investigating alterations in 3D portal venous hemodynamics patients liver cirrhosis compared healthy age-matched control subjects and young volunteers.This prospective study was approved by the local ethics committee, written informed consent...
Hepatocellular carcinoma (HCC) is one of the most severe sequelae chronic liver disease. The only potentially curative therapeutic options are surgical resection and orthotopic transplantation. In HCC patients, however, at clinical presentation tumors unresectable because multicentricity or poor hepatic functional reserve due to pre-existing cirrhosis not transplantable too advanced tumor stage co-morbidity. practice, therefore, percutaneous ethanol injection (PEI) transarterial...
<i>Aim:</i> To study whether an oat bran enriched diet has a specific effect in lowering total and low-density lipoprotein cholesterols, addition to caloric fat restriction. <i>Methods:</i> We performed randomized, controlled, parallel-group, single-centre which 1,994 patients from the Wehrawald Hospital (Todtmoos, Germany) were screened 235 met criteria male gender, hypercholesterolemia, overweight. All took part 4-week standardized inpatient lifestyle health program...
Abstract Background Impaired left and right ventricular function have been observed mainly in hospitalized patients with acute SARS-CoV-2 infection. The long-term cardiac sequelae not yet conclusively clarified large, well-defined cohorts. In addition, it is certain whether related to persistent cardiopulmonary symptoms or reduced exercise capacity after COVID-19. Purpose Differences structure suspected post-COVID syndrome (PCS) recovered control (CON) were analysed regard the association...
Impaired left and right ventricular (LV/RV) function during acute SARS-CoV-2 infection has been predominantly reported in hospitalized patients, but long-term cardiac sequelae large, well-characterized cohorts remain inconclusive. This study evaluated structure individuals with post-Coronavirus disease (COVID) syndrome (PCS) compared to recovered controls (CON), focusing on associations cardiopulmonary symptoms rapid physical exhaustion (RPE). multicenter, population-based included 1154...
Long- and post-COVID syndrome (PCS) affect at least 65 million individuals globally, with an estimated incidence of 10% among over 651 documented cases SARS-CoV-2 infection. PCS impacts nearly every organ system, posing significant challenges for healthcare systems patients. Despite this, effective guidelines multimodal training or rehabilitation remain absent. The app-based physical intervention long- treatment (A PILOT) study is a prospective, multicentre, two-armed, randomised controlled...
Background Preventing needlestick injuries caused by hypodermic needles is crucial for healthcare personnel. In this context, port access play an important role. However, systematic comparisons of different safety-engineered have not been conducted. Therefore, we evaluated differences in product characteristics and user preferences protection mechanisms needles. Methods Port puncture was performed using with four safety mechanisms: (a) EZ Huber™ PFM Medical, (b) Gripstick® Safety OMT, (c)...
The interrelation between physical exercise and plasma levels of homocysteine (Hcy), vitamin B(12), folic acid has not been examined. Therefore, we investigated the influence extensive endurance training acute intense on concentrations total Hcy, in 42 well-trained male triathletes. Examinations blood sampling took place before after a 30-day period as well 1 24 h competitive (sprint triathlon). Following period, no significant change Hcy could be detected for whole group. Subgroup analysis...
<i>Aim:</i> Our objective was to assess alterations in metabolic risk factors, body weight, fat mass and hormonal parameters following 6 weeks of lifestyle intervention with increased physical activity either a meal-replacement regimen or low calorie diet. <i>Research Methods Procedures:</i> 90 overweight obese subjects (age 47 ± 7.5 years, weight 90.6 11.3 kg, BMI 31.5 2.3) were included this randomized controlled clinical trial. Subjects the fat-restricted...
To evaluate the feasibility of time-resolved flow-sensitive MRI for three-dimensional (3D) visualization and quantification normal pathological portal venous (PV) hemodynamics.Portal hemodynamics were evaluated in 18 healthy volunteers 5 patients with liver cirrhosis. ECG- adaptive respiratory navigator gated 4D (time-resolved 3D three-directional velocity encoding) was performed on a 3 Tesla MR system (TRIO, Siemens, Germany). Qualitative flow analysis achieved using streamlines particle...
To determine changes in body composition, physical performance, metabolic and hormonal parameters induced by lifestyle counselling, resistance training with soy protein based supplemention middle aged males.Randomised controlled study consisting of without (RT-G) or (RTS-G) a supplement control group education only (LE-G).Forty healthy men (50-65 years, BMI 25-29.9 kg/m2).Changes weight (BW) waist circumference (WC) were measured composition (BC), fat mass (FM), lean (LBM) skin fold...