A5043218216- Microscopic Colitis
- Inflammatory Bowel Disease
- Hidradenitis Suppurativa and Treatments
- Genetic factors in colorectal cancer
- Celiac Disease Research and Management
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Diverticular Disease and Complications
- Colorectal Cancer Treatments and Studies
- Blood transfusion and management
- Clinical practice guidelines implementation
- Fermentation and Sensory Analysis
- Intraperitoneal and Appendiceal Malignancies
- Antiplatelet Therapy and Cardiovascular Diseases
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Potassium and Related Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Intestinal Malrotation and Obstruction Disorders
- Immune Cell Function and Interaction
- Therapeutic Uses of Natural Elements
- Clinical Laboratory Practices and Quality Control
- Pathogenesis and Treatment of Hiccups
- Patient-Provider Communication in Healthcare
- Intestinal and Peritoneal Adhesions
Linköping University
2014-2025
Linköping University Hospital
2013-2024
Medical University of Graz
2007-2017
University of Brescia
2015
Goethe University Frankfurt
2005-2006
Jackson Laboratory
1996
Hôpital Robert-Debré
1989
Low vitamin D status is linked to increased mortality and morbidity in patients who are critically ill. It unknown if this association causal.To investigate whether a D3 treatment regimen intended restore maintain normal over 6 months of health benefit for ICUs.A randomized double-blind, placebo-controlled, single-center trial, conducted from May 2010 through September 2012 at 5 ICUs that included medical surgical population 492 ill adult white with deficiency (≤20 ng/mL) assigned receive...
Abstract Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost endoscopic appearance of the colon, watery, nonbloody diarrhoea and distinct histological abnormalities, which identify three subtypes, collagenous colitis, lymphocytic incomplete microscopic colitis. With ongoing uncertainties new developments in clinical management there need for evidence‐based guidelines to improve medical care patients suffering from this disorder. Methods...
Background. We described three patients with collagenous colitis (CC) who developed side effects or were refractory to both budesonide and methotrexate given adalimumab (ADA) as a third-line treatment. Method/Patients. Three (two women, mean age 45 years one man, 74 old) included. Mean bowel movements per day week calculated stool weight/24 h registered prior following ADA was in doses 160 mg s.c. (baseline), 80 (week 2) 40 4). Sigmoidoscopies biopsies performed at baseline after 6 weeks...
<h3>Objective</h3> This 1-year study aimed to assess low-dose budesonide therapy for maintenance of clinical remission in patients with collagenous colitis. <h3>Design</h3> A prospective, randomised, placebo-controlled beginning an 8-week open-label induction phase which histologically confirmed active colitis received (Budenofalk, 9 mg/day initially, tapered 4.5 mg/day), after 92 were randomised (mean dose mg/day; Budenofalk 3 mg capsules, two or one capsule on alternate days) placebo a...
Lymphocytic colitis is a common cause of chronic, nonbloody diarrhea. However, the effects treatment are unclear and randomized placebo-controlled trials were requested in Cochrane review. We performed randomized, placebo-controlled, multicenter study to evaluate budesonide mesalazine as induction therapy for lymphocytic colitis.Patients with active randomly assigned groups given 9 mg once daily (Budenofalk granules), 3 g (Salofalk or placebo 8 weeks double-blind, double-dummy design. The...
Microscopic colitis (MC) is a common chronic diarrhoeal disease, and remission can be induced with budesonide. However, diarrhoea relapses frequently when budesonide tapered few patients become intolerant.To examine retrospectively the effect of azathioprine (AZA) mercaptopurine (MP) in chronic, active MC.Data on all MC who received AZA or MP years 1997-2011 at three centres representing countries were pooled for analysis. The indications thiopurine therapy frequent after short-term...
Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology CC unknown, and still poor understanding its pathogenesis. This possibly involves dysregulated inflammation immune-mediated reactions genetically predisposed individuals, but contribution genetic factors to underinvestigated. We systematically tested immune-related genes known impact risk several autoimmune diseases for their potential CC-predisposing...
Objectives: Onset of microscopic colitis (MC) in patients with ulcerative (UC) or Crohn's disease (CD), vice versa, has been reported occasionally but the subject is not well described. We therefore report a retrospective observational study such and review literature.Methods: Forty-six Swedish gastroenterology clinics were contacted about diagnoses both inflammatory bowel (IBD) MC. Publications searched on PubMed.Results: identified 31 onset MC after median (range) 20 (2–52) years diagnosis...
Bile acids in mM concentrations are known to increase chloride secretion and alter mucosal permeability animal colon. Increased is believed play an important role the development of intestinal inflammation. The aim this study was investigate influence microM dihydroxy bile on bacterial uptake normal human colon.Endoscopic biopsies from sigmoid colon 18 subjects with colonic histology were mounted modified Ussing chambers. Chenodeoxycholic acid (CDCA) deoxycholic (DCA) added compartment....
Evidence for second-line therapy in patients with microscopic colitis [MC] failing budesonide is scarce, although anti-tumour necrosis factors [anti-TNFs], methotrexate and azathioprine have been reported to be effective small cohort studies. Vedolizumab, a monoclonal antibody targeting α4β7-integrin, prevents homing of T-cells the gut. We evaluated clinical remission vedolizumab budesonide-refractory MC patients.We solicited gastroenterologists Europe Canada cases treated vedolizumab....
Epidemiological studies suggest an increasing global incidence of microscopic colitis, including collagenous colitis and lymphocytic colitis. We aimed to investigate the prevalence in Denmark.In a nationwide cohort study, we included all incident patients with recorded diagnosis or Danish Pathology Register between 2001 2016.A total 14 302 colitis-8437 [59%] 5865 [41%] colitis-were identified during study period. The December 2016 was estimated be 197.9 cases per 100 000 inhabitants....
Abstract Background and Aims Diarrhoea is a common, debilitating symptom of gastrointestinal disorders. Pathomechanisms probably involve defects in trans-epithelial water transport, but the role aquaporin [AQP] family channels diarrhoea-predominant diseases unknown. We investigated involvement AQPs pathobiology collagenous colitis [CC], which features chronic, watery diarrhoea despite overtly normal intestinal epithelial cells [IECs]. Methods assessed expression all AQP members mucosal...
Abstract Background The pathobiology of the moderate/non-destructive inflammatory bowel disease (IBD) lymphocytic colitis (LC) is poorly understood. We aimed to define an LC-specific mucosal transcriptome gain insight into LC pathology, identify unique genomic signatures, and uncover potentially druggable pathways. Methods performed bulk RNA-sequencing collagenous (CC) colonic mucosa from patients with active disease, healthy controls (n=4-10 per cohort). Differential gene expression was...
Objective: Microscopic colitis (MC), encompassing collagenous (CC) and lymphocytic (LC), is a diagnosis which relies on histopathologic criteria. This report examines the validity of having MC in Swedish pathology registers.Methods: We reviewed patient charts from 215 randomly selected individuals 15 departments five healthcare regions Sweden with relevant histopathology code for colon biopsies. Information clinical symptoms laboratory data were obtained medical chart review. sufficient 211...
Abstract Background and Aims The disease course of microscopic colitis [MC] is considered chronic but benign. However, this assumption based on mainly retrospective studies, reporting incomplete follow-up selective cohorts. Systematic, prospective unbiased data to inform patients healthcare professionals the expected real-life response therapy are warranted. Methods A prospective, pan-European, multi-centre, web-based registry was established. Incident cases MC were included. Data patient...
Collagenous colitis has become a more frequent diagnosis but the aetiology of this disease is still unknown. We describe female patient with intractable collagenous who was treated temporary loop ileostomy. She followed clinically, histopathologically, and functionally by measuring mucosal permeability before surgery, after ileostomy, bowel reconstruction. In our case report, active combined increased transcellular paracellular permeability. Diversion faecal stream decreased inflammation...
The relationship between clinical and histological parameters in collagenous colitis (CC) is poorly understood. Smoking a risk factor for CC, whereas its impact on activity outcome not well known. In post hoc analysis of pooled data from two randomized controlled trials we assessed the association demographic (gender, age, smoking habits, family history inflammatory bowel disease), variables (duration symptoms, mean number stools/watery stools per day, abdominal pain, remission) (thickness...
OBJECTIVES: Collagenous colitis is increasingly recognized as a common diarrheal disorder of inflammatory origin. Intestinal inflammation generally associated with increased mucosal permeability, but little known about barrier function in microscopic colitis. Our aim was to investigate the nonpathogenic bacteria collagenous METHODS: The study included 33 individuals, 25 (14 clinical remission, 11 active disease, and 8 these again after 6 weeks budesonide treatment) control patients. Bowel...