A5078501643- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Fibrosis and Remodeling
- Viral Infections and Immunology Research
- Congenital heart defects research
- Signaling Pathways in Disease
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cardiovascular Effects of Exercise
- Cancer-related molecular mechanisms research
- Antiplatelet Therapy and Cardiovascular Diseases
- Vitamin D Research Studies
- Corrosion Behavior and Inhibition
- Parathyroid Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- RNA Research and Splicing
- Mitochondrial Function and Pathology
Medical University of Graz
2013-2025
Medical University of Vienna
2019
Wilhelminen Hospital
2019
Erasmus MC
2017
University of California, Davis
2014
Cardiff Metropolitan University
2014
Cardiff University
2014
Ludwig Boltzmann Institute for Lung Vascular Research
2013-2014
Ludwig Boltzmann Institute for Translational Heart Failure Research
2013-2014
Philipps University of Marburg
2014
MicroRNAs are recently discovered regulators of gene expression and becoming increasingly recognized as important heart function. Genome-wide profiling microRNAs in human failure has not been reported previously. We measured 428 67 left ventricular samples belonging to control (n = 10), ischemic cardiomyopathy (ICM, n 19), dilated (DCM, 25), or aortic stenosis (AS, 13) diagnostic groups. miRNA between disease groups was compared by ANOVA with Dunnett's post hoc test. controlled for multiple...
Low vitamin D status is linked to increased mortality and morbidity in patients who are critically ill. It unknown if this association causal.To investigate whether a D3 treatment regimen intended restore maintain normal over 6 months of health benefit for ICUs.A randomized double-blind, placebo-controlled, single-center trial, conducted from May 2010 through September 2012 at 5 ICUs that included medical surgical population 492 ill adult white with deficiency (≤20 ng/mL) assigned receive...
Insulin-like growth factor 1 (IGF1) was considered a potential candidate for the treatment of heart failure. However, some animal studies and clinical trials have questioned whether elevating IGF1 chronically is beneficial. Secondary effects increased serum levels on other tissues may explain these unfavorable results. The aim current study to examine role in cardiac myocytes absence secondary effects, elucidate downstream signaling pathways transcriptional regulatory receptor (IGF1R)....
Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect attenuated IGF1 signaling on cardiac aging remains controversial. Methods: We performed lifelong study to assess health lifespan in 2 cardiomyocyte-specific transgenic mouse models with enhanced versus reduced receptor (IGF1R) signaling. Male mice human IGF1R overexpression or dominant negative phosphoinositide...
Background— RNA interference (RNAi) has the potential to be a novel therapeutic strategy in diverse areas of medicine. Here, we report on targeted RNAi for treatment heart failure, an important disorder humans that results from multiple causes. Successful failure is demonstrated rat model transaortic banding by targeting phospholamban, key regulator cardiac Ca 2+ homeostasis. Whereas gene therapy rests recombinant protein expression as its basic principle, uses regulatory RNAs achieve...
An important event in the pathogenesis of heart failure is development pathological cardiac hypertrophy. In cultured cardiomyocytes, transcription factor Gata4 required for agonist-induced We hypothesized that, intact organism, an regulator postnatal function and hypertrophic response to stress. To test this hypothesis, we studied mice heterozygous deletion second exon ( G4D ). At baseline, had mild systolic diastolic dysfunction associated with reduced weight decreased cardiomyocyte number....
Alternative mRNA splicing is an important mechanism for regulation of gene expression. Altered occurs in association with several types cancer, and a small number disease-associated changes have been reported heart disease. However, genome-wide approaches not used to study We hypothesized that different diseased hearts compared control hearts.
Understanding the genetic architecture of cardiac structure and function may help to prevent treat heart disease. This investigation sought identify common variations associated with inter-individual variability in function.
Caspase-9 is a critical regulator of mitochondria-mediated apoptosis. We found that adult cardiac myocytes, but not nonmyocytes, have high caspase-9 expression, and exhibit relative resistance to caspase-9-induced cell death. Thus, we hypothesized myocytes possess factors resist Through yeast two-hybrid screening human heart cDNA library, identified HS-1 associated protein-1 (HAX-1), 35-kD BH-domain containing protein localized the mitochondria as one molecules interacts with caspase-9....
The transcription factor GATA-4 protects cardiomyocytes against doxorubicin-induced cardiotoxicity. Here, we report the identification of Bcl2 as a direct target gene GATA4 that may mediate prosurvival function in cardiomyocytes. transcript and protein levels were reduced by doxorubicin neonatal rat ventricular (NRVC) mouse heart determined RT-PCR Western blot analysis. reduction was prevented overexpression NRVC transgenic heart. Also, expression increased baseline 30% 2.7-fold heart,...
A hallmark of heart failure is impaired cytoplasmic Ca(2+) handling cardiomyocytes. It remains unknown whether specific alterations in nuclear via altered excitation-transcription coupling contribute to the development and progression failure.Using tissue isolated cardiomyocytes from nonfailing failing human hearts, as well mouse rabbit models hypertrophy failure, we provide compelling evidence for structural functional changes envelope remodeling progresses. Increased size less frequent...
Abstract Background and purpose Atrial fibrillation (AF) often remains undiagnosed in cryptogenic stroke (CS), mostly because of limited availability cardiac long‐term rhythm monitoring. There is an unmet need for a pre‐selection CS patients benefitting from such work‐up. A clinical risk score was therefore developed the prediction AF after its performance evaluated over 1 year follow‐up. Methods Our proposed ranges 0 to 16 points comprises variables known be associated with occult including...
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane proton carrier that uncouples ATP synthesis. The aim of this study was to determine whether UCP2 plays a role in survival adult rat cardiac myocytes. We first studied the effects overexpression vitro. Overexpression primary cardiomyocytes led significant decline level and development acidosis but had no observable effect on cell survival. When were challenged with hypoxia-reoxygenation, cells overexpressing survived significantly...
Background and Purpose- Occult atrial fibrillation (AF) causes a relevant proportion of initially cryptogenic stroke (CS), but prolonged rhythm monitoring is difficult to apply all such patients. We hypothesized that blood biomarkers indicating heart failure (NT-proBNP [N-terminal pro-brain natriuretic peptide]) hypercoagulability (D-dimer, AT-III [antithrombin-III]) were associated with AF-related could serve predict the likelihood AF detection in CS patients early on. Methods- Over 1-year...
BACKGROUND: Atrial fibrillation detected after stroke (AFDAS) affects secondary prevention, yet identification can be challenging. Easily accessible cardiac blood biomarkers such as NT-proBNP (N-terminal pro-B-type natriuretic peptide) could guide diagnostic workup, but optimal cutoff values and the time-dependent relationship between AFDAS are unclear. We aimed (1) to externally validate earlier presented cutoffs for atrial prediction (2) assess of early in-hospital versus discharge....
Insulin-like growth factor 1 (IGF1) promotes a physiological type of cardiac hypertrophy and has therapeutic effects in heart disease. Here, we report the relationship IGF1 to GATA4, an essential transcription cell survival. In cultured neonatal rat ventricular myocytes, compared responses (10 nmol/liter) phenylephrine (PE, 20 μmol/liter), known GATA4 activator, concentrations promoting similar extent hypertrophy. PE both increased nuclear accumulation phosphorylation at Ser(105) 2.4-fold;...
X-linked myopathy with postural muscle atrophy is a novel caused by mutations in the four-and-a-half LIM domain 1 gene (FHL1). Cardiac involvement was suspected initial publications. We now systematically analyzed association of FHL1 genotype cardiac phenotype to establish potential disease.Seventeen male patients and 23 female mutation carriers were compared healthy controls. Every patient underwent comprehensive clinical cardiovascular workup. ECG abnormalities occurred frequently affected...
Adrenomedullin (ADM) is an endogenous peptide with favorable hemodynamic effects in vivo. In this study, we characterized the direct functional of ADM isolated preparations from human atria and ventricles. electrically stimulated nonfailing right atrial trabeculae, (0.0001-1 micromol/l) increased force contraction a concentration-dependent manner, maximal increase by 35 +/- 8% (at 1 micromol/l; P < 0.05). The positive inotropic effect was accompanied disproportionate calcium transients...
Non-alcoholic fatty liver disease and particularly fibrosis are related to cardiovascular may indicate an increased risk for atrial fibrillation (AF), but this association has not yet been systematically investigated in a cohort of ischemic stroke patients.We analyzed data from prospective single-center study enrolling all consecutive patients admitted our unit over 1-year period. All received thorough etiological workup. For evaluation fibrosis, we determined the Fibrosis-4 (FIB-4) index,...