A5060855605- Ion channel regulation and function
- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Genetic Neurodegenerative Diseases
- Myasthenia Gravis and Thymoma
- Muscle Physiology and Disorders
- Nerve injury and regeneration
- Peripheral Nerve Disorders
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Neurogenetic and Muscular Disorders Research
- Viral Infections and Immunology Research
- Multiple Myeloma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Myofascial pain diagnosis and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Effects of Exercise
- Biomedical and Chemical Research
- Nerve Injury and Rehabilitation
- Orthopedic Surgery and Rehabilitation
Medical University of Graz
2012-2024
University of Graz
2000-2018
Medical University of Vienna
2001-2017
Hospital of the Brothers of St. John of God
2012-2014
Cardiovascular Institute of the South
2012
Centre for Addiction and Mental Health
2012
Ludwig-Maximilians-Universität München
1990-2009
Johannes Wesling Klinikum Minden
2009
Johannes Gutenberg University Mainz
2009
University College London
2007
Cardiac troponins are often elevated in patients with skeletal muscle disease who have no evidence of cardiac disease. The goal this study was to characterize troponin concentrations myopathies and derive insights regarding the source T measurements. (cTnT) I (cTnI) were determined by using high sensitivity assays 74 hereditary acquired myopathies. Patients underwent comprehensive evaluation, including 12-lead electrocardiogram, 24-h magnetic resonance imaging, coronary artery computed...
The blocking efficacy of 4,9-anhydro-TTX (4,9-ah-TTX) and TTX on several isoforms voltage-dependent sodium channels, expressed in Xenopus laevis oocytes, was tested (Na v1.2 , Na v1.3 v1.4 v1.5 v1.6 v1.7 v1.8 ). Generally, 40–231 times more effective, when compared with 4,9-ah-TTX, a given isoform. An exception where 4,9-ah-TTX nanomole per liter concentrations sufficed to result substantial block, indicating that acts specifically at this peculiar IC 50 values for TTX/4,9-ah-TTX were as...
Objective To compare ultrasound measurement of median nerve cross-sectional area (CSA) at different anatomical landmarks and to assess the value power Doppler signals within for diagnosis carpal tunnel syndrome (CTS). Methods A prospective study 135 consecutive patients with suspected CTS undergoing two visits 3 months. final was established by clinical electrophysiological findings. CSA sonographically measured five levels forearm wrist; wrist ratios or differences were calculated....
An abnormal axonal membrane conductance might contribute to human diabetic neuropathy. To test this idea, we have compared the threshold changes produced by long-lasting (100–200 ms) de- and hyperpolarizing currents applied median motor sensory axons at wrist in 63 patients with those from 50 normal controls 27 amyotrophic lateral sclerosis (ALS) patients. Averages of electrotonus plots for showed more subexcitability during, slower recovery following, application currents. Such alterations...
Grafe, Peter, Stefan Quasthoff, Julian Grosskreutz, and Christian Alzheimer. Function of the hyperpolarization-activated inward rectification in nonmyelinated peripheral rat human axons. J. Neurophysiol. 77: 421–426, 1997. The function time-dependent, was analyzed on compound potentials axons mammalian nervous system. Isolated vagus nerves fascicles biopsied sural nerve were tested a three-chambered, Vaseline-gap organ bath at 37°C. Inward assessed by recording effects long-lasting...
<b>Background:</b> Mutations in the four-and-a-half LIM domain 1 gene (<i>FHL1</i>) cause X-linked late-onset scapuloaxioperoneal myopathy characterized by postural muscle atrophy with rigid spine syndrome pseudoathleticism/hypertrophy (XMPMA), reducing body (RBM), and scapuloperoneal myopathy. Divergences these diseases are hitherto unclear; therefore, we searched for additional families to elucidate differences similarities of allelic FHL1opathies. <b>Methods:</b> Using genotyping...
In the absence of clinical signs, elevated values cardiac isoforms troponin T (cTnT) and I (cTnI) can be found in serum samples some patients with skeletal muscle myopathies; cause is unclear. We studied messenger RNA (mRNA) expression cTnT cTnI muscles 24 histologically proven myopathies 18 whom a myopathy could excluded. For cTnT- cTnI-mRNA determination, we designed specific primer pairs for nested polymerase chain reaction. After amplification, products were digested 2 restriction...
Abstract An abnormal ratio between Na + and K conductances seems to be the cause for depolarization paralysis of skeletal muscle in primary hypokalemic periodic paralysis. Recently we have shown that „k channel opener”︁ cromakalim hyperpolarizes mammalian fibers. Now studied effects this drug on twitch force biopsies from normal diseased human muscle. Cromakalim had little effect whereas it strongly improved contraction fibers patients suffering Recordings intracellular Cl − activities...
Oxaliplatin has been proven antitumoral activity in numerous clinical trials. Peripheral sensory neuropathy with predominantly hyperpathic symptoms induced by cold is the most severe and dose-limiting toxicity resulting from oxaliplatin therapy. We demonstrated that alters sodium channel kinetics on neurons. This effect could be antagonized vitro blocker carbamazepine. Therefore a pilot study was initiated to investigate if carbamazepine prevents oxaliplatin-induced patients colorectal...
Abstract Purpose: To test if and where increased iron accumulation occurs in amyotrophic lateral sclerosis (ALS) by quantitative mapping of deposition to relate these findings white matter tract degeneration assessed diffusion tensor imaging (DTI). Materials Methods: Fifteen patients with ALS 15 age‐ gender‐matched controls underwent MRI the brain obtain R 2 * relaxation rate DTI measurements, focusing on corticospinal (CST) deep gray structures, using tract‐based spatial statistics (TBSS)....
In this study, we performed a survey of infantile and late-onset Pompe disease (IOPD LOPD) in Austria. Paediatric neuromuscular centres were contacted to provide set anonymized clinical genetic data patients with IOPD LOPD. The number receiving enzyme replacement therapy (ERT) was obtained from the pharmaceutical company providing alglucosidase alfa. We found 25 24 families, 4 21 LOPD resulting prevalence 1:350,914. most frequent manifestation lower limb-girdle phenotype combined axial...
Abstract Introduction/Aims The clinical presentation of multifocal motor neuropathy (MMN) may mimic early amyotrophic lateral sclerosis (ALS) with predominant lower neuron (LMN) involvement, posing a diagnostic challenge. Both diseases have specific treatments and prognoses, highlighting the importance diagnosis. aim this study was to assess value serum neurofilament light chain (NfL) in differentiating MMN from LMN dominant ALS. Methods NfL measured n = 37 patients age‐ sex‐matched ALS,...
Abstract Idiopathic peripheral facial nerve palsy has been associated with the reactivation of herpes simplex virus type 1 (HSV‐1) or varicella zoster (VZV). In recent studies, detection rates were found to vary strongly which may be caused by use different oral fluid collection devices in combination molecular assays lacking standardization. this single‐center pilot study, liquid phase‐based and absorption‐based was compared. Samples collected both systems from 10 patients acute idiopathic...