A5073597054- Microscopic Colitis
- Inflammatory Bowel Disease
- Hidradenitis Suppurativa and Treatments
- Amino Acid Enzymes and Metabolism
- Drug Transport and Resistance Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Genetic factors in colorectal cancer
- Clinical Nutrition and Gastroenterology
- Celiac Disease Research and Management
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Clostridium difficile and Clostridium perfringens research
- Ion Transport and Channel Regulation
- Gastroesophageal reflux and treatments
- Child and Adolescent Health
- Gastrointestinal motility and disorders
- Clinical practice guidelines implementation
- Aldose Reductase and Taurine
- Poisoning and overdose treatments
- Biotechnology and Related Fields
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Pharmaceutical Practices and Patient Outcomes
- Electronic Health Records Systems
- Gallbladder and Bile Duct Disorders
University of Copenhagen
2013-2024
Zealand University Hospital Køge
2013-2024
Zealand University Hospital
2017-2023
Danish Medicines Agency
2007
Roskilde Sygehus
2002-2006
Muslim University of Morogoro
1992-1997
Herlev Hospital
1997
Hvidovre Hospital
1994
Bispebjerg Hospital
1982-1993
Gentofte Hospital
1992
Although the reasons for secondary loss of response to infliximab (IFX) maintenance therapy in Crohn's disease vary, dose intensification is usually recommended. This study investigated cost-effectiveness interventions defined by an algorithm designed identify specific therapeutic failure.Randomised, controlled, single-blind, multicentre study. 69 patients with IFX failure were randomised (5 mg/kg every 4 weeks) (n=36) or based on serum and antibody levels using proposed (n=33). Predefined...
Abstract Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost endoscopic appearance of the colon, watery, nonbloody diarrhoea and distinct histological abnormalities, which identify three subtypes, collagenous colitis, lymphocytic incomplete microscopic colitis. With ongoing uncertainties new developments in clinical management there need for evidence‐based guidelines to improve medical care patients suffering from this disorder. Methods...
Importance The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit IL-23) for treatment ulcerative colitis are unknown. Objective To evaluate efficacy and safety when administered as an induction a maintenance therapy patients with colitis. Design, Setting, Participants Two phase 3 randomized trials were conducted. trial was conducted at 261 centers (in 41 countries) enrolled 977 from November 5, 2020, to August 4, 2022 (final follow-up on May 16,...
To describe mortality by suicide and other causes of death in a group patients who attempted suicide, to identify predictive factors.10 year follow up study based on records attempters 1980.Poisoning treatment centre at general hospital.974 aged 15 over referred the poisoning after deliberate self poisoning.Death different registered Danish cause register.In 10 years 306 died: 103 131 from natural causes, 31 accident; five were murdered, 36 cases was uncertain. The standard ratio 550. Cause...
Uncertainty remains on topography and persistence of histological subgroups microscopic colitis (MC).To assess longitudinal clinical, endoscopic, histological, therapeutic description MC including patients with incomplete findings (MCi).Retrospective review a consecutive cohort reassessment MCi.Clinical characteristics 168 lymphocytic (LC), 270 collagenous (CC) 101 MCi were similar. At colonoscopy 95% (95% CI: 91-98%) CC 98% (93-100%) LC cases had diagnostic histopathology in both left right...
Microscopic colitis (MC) is a common cause of chronic watery diarrhoea but long-term follow-up data are sparse.We performed retrospective review health records and all pathology reports in regional cohort patients with MC to describe the change pre- post-diagnostic colon biopsies.MC was diagnosed 468 collagenous (CC), 361 lymphocytic (LC) 226 incomplete (MCi). The 2014 incidence CC, LC MCi 14.5, 14.9 5 per 10(5). Biopsies from both right left were obtained 237 (51%) 200 (55%) 107 (47%) MCi....
Lymphocytic colitis is a common cause of chronic, nonbloody diarrhea. However, the effects treatment are unclear and randomized placebo-controlled trials were requested in Cochrane review. We performed randomized, placebo-controlled, multicenter study to evaluate budesonide mesalazine as induction therapy for lymphocytic colitis.Patients with active randomly assigned groups given 9 mg once daily (Budenofalk granules), 3 g (Salofalk or placebo 8 weeks double-blind, double-dummy design. The...
BackgroundProbiotic treatment may be effective in diseases involving gut microflora and intestinal inflammation. In collagenous colitis (CC), a potential pathogenic role of the has been proposed. The effect probiotic CC is unknown. Our aim was to investigate clinical with Lactobacillus acidophilus LA-5 Bifidobacterium animalis subsp. lactis BB-12 (AB-Cap-10) patients CC.
AbstractThe irritable bowel syndrome is the commonest diagnosis in gastroenterological clinics, although diagnostic criteria and investigatory programs vary. To elucidate safety prognosis of syndrome, a retrospective study was conducted. One hundred twelve consecutive patients with as final only abdominal period 1977-79 were followed up 1984. Seventeen died during follow-up period; two these considered failures (chronic pancreatitis pancreatic cancer). Of remaining 95 patients, 93 available...
Microscopic colitis (MC) is a common chronic diarrhoeal disease, and remission can be induced with budesonide. However, diarrhoea relapses frequently when budesonide tapered few patients become intolerant.To examine retrospectively the effect of azathioprine (AZA) mercaptopurine (MP) in chronic, active MC.Data on all MC who received AZA or MP years 1997-2011 at three centres representing countries were pooled for analysis. The indications thiopurine therapy frequent after short-term...
Intensification of the infliximab (IFX) regimen is recommended if treatment effect inadequate. However, rationale for this not well defined as underlying mechanisms vary. The aim study was to explore association between changes in serum IFX and anti-IFX antibodies (Abs) after intensification clinical outcomes. We performed a post hoc analysis randomized trial including 42 Crohn's disease patients with failure, all treated an intensified (5mg/kg every 4 week) 12 weeks. Trough Ab...
Microscopic colitis is a disease of unknown aetiology characterized by chronic watery diarrhoea and can be eliminated budesonide but frequently recurs when stopped. We studied whether prednisolone could induce remission in patients with disabling, due to microscopic colitis.A double-blind, randomized (3:1) trial oral 50 mg daily or placebo for 2 weeks. Remission was defined as stool weight < = 200 g/day frequency 2/day; effect > 50% reduction either weight. Six centres screened 31...
Abstract This study aimed to assess the clinical oral health outcome effects among schoolchildren participating in a school‐based education (OHE) programme. Local social, cultural and environmental conditions were determinants of OHE programme, which was compiled on basis prevailing beliefs what teachers educational authorities considered be important for schoolchildren. Consequently, practical aspects hygiene information cause prevention caries gingivitis components education. The prepared...
To widen the selection of proteins for gene expression studies in barley seeds, experiments were performed to identify whose synthesis is differentially regulated developing and germinating seed tissues. The vitro nine distinct was compared using mRNAs from isolated endosperm aleurone tissues (developing mature grain) cultured (germinating) layers treated with abscisic acid (ABA) GA(3). B C hordein polypeptides salt-soluble beta-amylase, protein Z, C, chymotrypsin inhibitors (CI-1 2),...
Summary Introduction : Azathioprine is effective for maintenance of remission in Crohn's disease, however, duration efficacy and the dose response relationship has not been fully evaluated. Aims To investigate whether patients kept by azathioprine treatment >2 years benefit from further treatment, to explore dose–response relationship. Patients methods In an open 12‐month trial, with inactive disease after (median 37 months) were randomized withdrawal or continued treatment. Primary end...
Objective: The significantly higher incidence rates of microscopic colitis (MC) in Denmark compared to Sweden remains unexplained.Methods: Consecutive patients with newly diagnosed MC the neighbouring regions Skåne 2011–2015 and Zealand 2010–2016 were prospectively identified. Data on large bowel endoscopies biopsies retrieved. Information putative factors obtained from registers literature. Interobserver agreement between pathologists both 40 blinded hematoxylin eosin (H&E)-stained colon...
Background and aim: Microscopic colitis (MC) is an inflammatory disease of the bowel, hypothetically induced by immunologic response to a luminal microbial agent. We aimed characterize microbiome composition in MC subtypes collagenous (CC) lymphocytic (LC) identify possible effect treatment. Method: Stool samples were collected from patients prior treatment, at 8 weeks (during treatment) 16 (after treatment), healthy controls, not receiving matched time-points. Microbiome was analyzed...