A5108046731- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Diamond and Carbon-based Materials Research
- Electrospun Nanofibers in Biomedical Applications
- Fluid Dynamics and Mixing
- Metal and Thin Film Mechanics
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Graphene and Nanomaterials Applications
- Cancer, Hypoxia, and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Innovative Microfluidic and Catalytic Techniques Innovation
- Dendrimers and Hyperbranched Polymers
- Osteoarthritis Treatment and Mechanisms
- Membrane Separation Technologies
- Intermetallics and Advanced Alloy Properties
- Enzyme Catalysis and Immobilization
- Hydrogels: synthesis, properties, applications
- Force Microscopy Techniques and Applications
- Photodynamic Therapy Research Studies
- RNA modifications and cancer
- Cellular Mechanics and Interactions
- Cyclone Separators and Fluid Dynamics
Fudan University
2011-2025
Southwest Petroleum University
2022-2025
Pudong Medical Center
2019-2025
Yan'an University
2025
Beihang University
2012-2024
Beijing Proteome Research Center
2023-2024
First Affiliated Hospital of Kunming Medical University
2015-2024
Tianjin University of Science and Technology
2022-2024
Kunming Medical University
2015-2024
Southeast University
2020-2024
A stimuli-responsive polymeric prodrug-based nanotheranostic system with imaging agents (cyanine5.5 and gadolinium-chelates) a therapeutic agent paclitaxel (PTX) is prepared via polymerization conjugating chemistry. The branched PTX-Gd-based nanoparticles (BP-PTX-Gd NPs) demonstrate excellent biocompatibility, high stability under physiological conditions, but they stimuli-responsively degrade release PTX rapidly in tumor microenvironment. vitro behavior of NPs labeled fluorescent dyes...
To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction immunogenic cell death (ICD) at tumor sites can increase antigenicity and adjuvanticity to activate microenvironment so that tumors become sensitive intervention inhibitors. Herein, a self-amplified biomimetic nanosystem, mEHGZ, was constructed by encapsulation epirubicin (EPI), glucose oxidase (Gox) hemin ZIF-8...
Precisely delivering combinational therapeutic agents has become a crucial challenge for anti-tumor treatment. In this study, novel redox-responsive polymeric prodrug (molecular weight, MW: 93.5 kDa) was produced by reversible addition-fragmentation chain transfer (RAFT) polymerization. The amphiphilic block polymer-doxorubicin (DOX) employed to deliver hydrophobic photosensitizer (PS), chlorin e6 (Ce6), and the as-prepared nanoscale system [NPs(Ce6)] investigated as chemo-photodynamic...
Abstract Urea electrosynthesis from co–electrolysis of NO 3 − and CO 2 (UENC) offers a promising technology for achieving sustainable efficient urea production. Herein, diatomic alloy catalyst (CuPd 1 Rh –DAA), with mutually isolated Pd atoms alloyed on Cu substrate, is theoretically designed experimentally confirmed to be highly active selective UENC catalyst. Combining theoretical computations operando spectroscopic characterizations reveals the synergistic effect –Cu sites promote via...
It has been reported that disordered Cu metabolism is associated with several neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's (PD). However, the underlying mechanism still unclear. In this study, 4-week-old male mice were exposed to by free-drinking water for three months. Then, effects of on cognitive functions in tested Morris maze tests, potential mechanisms investigated ELISA, immunochemistry, TUNEL, Western blot tests. was found exacerbates learning memory...
Nanoprobes that offer both fluorescence imaging (FI) and magnetic resonance (MRI) can provide supplementary information hold synergistic advantages. However, synthesis of such dual-modality probes simultaneously exhibit tunability functional groups, high stability, great biocompatibility desired results remains challenging. In this study, we used an amphiphilic block polymer from (ethylene glycol) methyl ether methacrylate (OEGMA) N-(2-hydroxypropyl) methacrylamide (HPMA) derivatives as a...
Targeting metabolic vulnerability of tumor cells is a promising anticancer strategy. However, the therapeutic efficacy existing metabolism-regulating agents often compromised due to tolerance resulting from plasticity, as well their poor bioavailability and tumor-targetability. Inspired by inhibitive effect N-ethylmaleimide on mitochondrial function, dendronized-polymer-functionalized metal-phenolic nanomedicine (pOEG-b-D-SH@NP) encapsulating maleimide-modified doxorubicin (Mal-DOX)...
Cancer cells could be eradicated by promoting generation of excessive intracellular reactive oxygen species (ROS) via emerging nanomedicines. However, tumor heterogeneity and poor penetration nanomedicines often lead to diverse levels ROS production in the site, at a low level promote cell growth, thus diminishing therapeutic effect these Herein, we construct an amphiphilic block polymer-dendron conjugate-derived nanomedicine (Lap@pOEGMA-b-p(GFLG-Dendron-Ppa), GFLG-DP/Lap NPs) that...
Importance The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit IL-23) for treatment ulcerative colitis are unknown. Objective To evaluate efficacy and safety when administered as an induction a maintenance therapy patients with colitis. Design, Setting, Participants Two phase 3 randomized trials were conducted. trial was conducted at 261 centers (in 41 countries) enrolled 977 from November 5, 2020, to August 4, 2022 (final follow-up on May 16,...
Abstract Urea electrosynthesis from co‐electrolysis of CO 2 and NO 3 − (UECN) offers an innovative route for converting waste /NO into valuable urea. Herein, Zn single atoms anchored on oxygen vacancy (OV)‐rich In O 3‐x (Zn 1 /In ) are developed as a highly active selective UECN catalyst, delivering the highest urea yield rate 41.6 mmol h −1 g urea‐Faradaic efficiency 55.8% at −0.7 V in flow cell, superior to most previously reported catalysts. situ spectroscopic measurements theoretical...
Stem cell transplantation is currently implemented clinically but limited by low retention and engraftment of transplanted cells the adverse effects inflammation immunoreaction when allogeneic or xenogeneic are used. Here, we demonstrate safety efficacy encapsulating human cardiac stem (hCSCs) in thermosensitive poly(N-isopropylacrylamine-co-acrylic acid) P(NIPAM-AA) nanogel mouse pig models myocardial infarction (MI). Unlike hCSCs injected saline, injection nanogel-encapsulated does not...
Copper and its salts are abundant, inexpensive, eco-friendly have been used as the surrogates of noble metals to effect arene C–H bond activation transformations. Despite recent significant progress study, syntheses high-valent arylcopper(II–III) compounds still very rare mechanisms copper(II)-catalyzed reactions remain elusive. With use azacalix[1]arene[3]pyridines a platform, number arylcopper(II) were synthesized efficiently from reaction Cu(ClO4)2 under ambient conditions. The resulting...