A5100372245- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Luminescence Properties of Advanced Materials
- MicroRNA in disease regulation
- Advanced Battery Materials and Technologies
- CRISPR and Genetic Engineering
- Cancer Cells and Metastasis
- Cardiovascular Health and Disease Prevention
- Radiation Therapy and Dosimetry
- Molecular Sensors and Ion Detection
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Hypoxia, and Metabolism
- Nanocluster Synthesis and Applications
- Advanced Drug Delivery Systems
- Advancements in Battery Materials
Jilin Agricultural University
2025
Shandong Agricultural University
2015-2024
Tianjin University
2014-2024
Shenzhen University
2022-2024
Qingdao University
2022-2024
Affiliated Hospital of Qingdao University
2022-2024
Shandong Normal University
2024
Hebei Agricultural University
2024
Tianjin Medical University
2015-2023
Second Hospital of Tianjin Medical University
2015-2023
Computed tomography (CT) contrast and radiosensitization usually increase with particle sizes of gold nanoparticles (AuNPs), but there is a huge challenge to improve both by adjusting under the requirements in vivo application. Here, we report that AuNPs have great size-dependent enhancements on CT imaging as well radiotherapy (RT) size range 3–50 nm. It demonstrated ∼13 nm could simultaneously possess superior ability significant radioactive disruption. The Monte Carlo method further used...
Using the cytomembranes (FMs) of hybrid cells acquired from fusion cancer and dendritic (DCs), this study offers a biologically derived platform for combination immunotherapy traditional oncotherapy approaches. Due to immunoactivation implicated in cellular fusion, FMs can effectively express whole antigens immunological co-stimulatory molecules robust immunotherapy. share tumor's self-targeting character with parent cells. In bilateral tumor-bearing mouse models, FM-coated...
Cancer cells could be eradicated by promoting generation of excessive intracellular reactive oxygen species (ROS) via emerging nanomedicines. However, tumor heterogeneity and poor penetration nanomedicines often lead to diverse levels ROS production in the site, at a low level promote cell growth, thus diminishing therapeutic effect these Herein, we construct an amphiphilic block polymer-dendron conjugate-derived nanomedicine (Lap@pOEGMA-b-p(GFLG-Dendron-Ppa), GFLG-DP/Lap NPs) that...
One-for-all phototheranostics, referring to a single component simultaneously exhibiting multiple optical imaging and therapeutic modalities, has attracted significant attention due its excellent performance in cancer treatment. Benefitting from the superiority balancing diverse competing energy dissipation pathways, aggregation-induced emission luminogens (AIEgens) are proven be ideal templates for constructing one-for-all multimodal phototheranostic agents. However, this knowledge,...
Abstract The development of semiconducting polymers (SPs) with simultaneous second near‐infrared (NIR‐II) absorption and multimodal phototheranostic functions is highly desired in the field oncotherapy. Aggregation‐induced emission luminogens (AIEgens) have been acknowledged to possess unique potential integrating multiple diagnostic therapeutic modalities into one organic molecule. Nevertheless, SPs are hard achieve AIE activity due their extended π‐conjugated skeletons as well large planar...
In the risk-based security assessment, probability and severity of events are two main factors for measuring level power systems. This paper presents a method assessing line overload risk wind-integrated systems with consideration wind load-power generation correlation. The established assessment model fully considers consequence uncertainties flow fluctuations. point estimate is employed to deal function applied quantify Moreover, Cholesky decomposition, correlation between loads...
Convenient and fast testing using an immunochromatography test strip (ICTS) enables rapid yes/no decisions regarding a disease to be made. However, the fundamental limitations of ICTS, such as lack quantitative sensitive analysis, severely hampers its application in reliable medical for early detection cancer. Herein, we overcame these by integrating ICTS with quantum dot nanobeads (QD nanobeads), which were fabricated encapsulating QDs within modified poly(tert-butyl acrylate-co-ethyl...
Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application nanotechnology to medicine, and multimodality based on nanoparticles has been receiving extensive attention. This new hybrid technology could complementary information from different modalities using only a injection contrast agent. In this review, we introduce recent developments in multifunctional their...
Abstract One‐for‐all phototheranostics based on a single molecule is recognized as convenient approach for cancer treatment, whose efficacy relies precise lesion localization through multimodal imaging, coupled with the efficient exertion of phototherapy. To unleash full potential phototheranostics, advancement in both phototheranostic agents and light delivery methods essential. Herein, an integrated strategy combining versatile featuring aggregation‐induced emission, namely tBuTTBD,...
Abstract Realizing precise control of the therapeutic process is crucial for maximizing efficacy and minimizing side effects, especially strategies involving gene therapy (GT). Herein, a multifunctional Prussian blue (PB) nanotheranostic platform first designed then loaded with plasmid DNA (HSP70‐p53‐GFP) near‐infrared (NIR) light‐triggered thermo‐controlled synergistic GT/photothermal (PTT). Due to unique structure PB nanocubes, resulting PB@PEI/HSP70‐p53‐GFP nanoparticles (NPs) exhibit...
To integrate multiple diagnostic and therapeutic strategies on a single particle through simple effective methods is still challenging for nanotheranostics. Herein, we develop multifunctional nanotheranostic PB@Au core–satellite nanoparticles (CSNPs) based Prussian blue (PBNPs) gold (AuNPs), which are two kinds of intrinsic theranostic nanomaterials, magnetic resonance (MR)–computed tomography (CT) imaging synergistic photothermal radiosensitive therapy (PTT–RT). PBNPs as cores enable T1-...
Hypoxia-induced radioresistance is the primary reason for failure of tumor radiotherapy (RT). Changes within irradiated microenvironment (TME) including oxygen, reactive oxygen species (ROS) and nitric oxide (NO) are closely related to radioresistance. Therefore, there an urgent need develop new approaches overcoming hypoxic by incorporating TME regulation into current radiotherapeutic strategies.Herein, we explored a radiation-responsive nanotheranostic system enhance RT effects on tumors...
Abstract Cancer immunotherapy is revolutionary in oncology and hematology. However, a low response rate restricts the clinical benefits of this therapy owing to inadequate T lymphocyte infiltration delivery efficiency immunotherapeutic drugs. Herein, an intelligent nanovehicle (folic acid (FA)/1‐(4‐(aminomethyl) benzyl)‐2‐butyl‐1H‐imidazo[4,5‐c]quinolin‐4‐amine (IMDQ)‐oxaliplatin (F/IMO)@CuS) armed with multifunctional navigation designed for accurate cargoes tumor cells dendritic (DCs),...
The side effects of antitumor drugs and low treatment efficacy are two major challenges current chemotherapy. To address these issues, we developed a new kind smart nanocarriers that combine pH-responsive chemotherapy near-infrared (NIR) light triggered photodynamic therapy. These were based on upconversion nanoparticle (UCN)-loaded folate-conjugated polymeric lipid vesicles (UFPLVs). Merocyanine 540 (MC540), as photosensitizer, was loaded in the UFPLVs; doxorubicin hydrochloride (DOX), an...
Photodynamic therapy (PDT) based periodontal disease treatment has received extensive attention. However, the deep tissue location of plaque makes conventional PDT encounter a bottleneck. Herein, upconversion fluorescent nanomaterial with near-infrared light excitation was introduced into disease, overcoming limited penetration depth visible in PDT. Photosensitizer Ce6 molecules were combined nanoparticles (UCNPs) NaYF4:Yb,Er novel strategy. The hydrophobic UCNPs modified amphiphilic silane,...
Abstract Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single agent is an appealing yet significantly challenging task. Herein, precise dual‐acceptor engineering strategy exploited for this attempt based on donor‐acceptor (D‐A) type semiconductor polymers by subtly regulating molar proportions of two employed electron acceptor moieties featuring different electronic affinity π‐conjugation degrees, making...