A5102714272- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Perovskite Materials and Applications
- Geotechnical Engineering and Underground Structures
- Photochromic and Fluorescence Chemistry
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Molecular Sensors and Ion Detection
- Organic Electronics and Photovoltaics
- Advanced Fluorescence Microscopy Techniques
- Conducting polymers and applications
- Grouting, Rheology, and Soil Mechanics
- Antimicrobial Peptides and Activities
- Surface Chemistry and Catalysis
- Photochemistry and Electron Transfer Studies
- Geotechnical Engineering and Analysis
Guangzhou Medical University
2024
Shenzhen University
2022-2024
Shanghai Institute of Organic Chemistry
2020-2024
University of Chinese Academy of Sciences
2020-2024
State Key Laboratory of Respiratory Disease
2024
Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single agent is an appealing yet significantly challenging task. Herein, precise dual-acceptor engineering strategy exploited for this attempt based on donor-acceptor (D-A) type semiconductor polymers by subtly regulating molar proportions of two employed electron acceptor moieties featuring different electronic affinity π-conjugation degrees, making full use...
Abstract The development of semiconducting polymers (SPs) with simultaneous second near‐infrared (NIR‐II) absorption and multimodal phototheranostic functions is highly desired in the field oncotherapy. Aggregation‐induced emission luminogens (AIEgens) have been acknowledged to possess unique potential integrating multiple diagnostic therapeutic modalities into one organic molecule. Nevertheless, SPs are hard achieve AIE activity due their extended π‐conjugated skeletons as well large planar...
Abstract Photoactivatable agent is a powerful tool in biomedicine studies due to high‐precision spatiotemporal control of light. However, those previously reported agents generally suffer from short wavelength, fluorescence self‐quenching effect, and the lack photosensitizing property, which severely restrict their practical applications. To address these issues, molecular engineering 1,4‐dihydropyridine derivatives conducted obtain an optimized agent, namely TPA‐DHPy‐Py, exhibits low...
Abstract Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single agent is an appealing yet significantly challenging task. Herein, precise dual‐acceptor engineering strategy exploited for this attempt based on donor‐acceptor (D‐A) type semiconductor polymers by subtly regulating molar proportions of two employed electron acceptor moieties featuring different electronic affinity π‐conjugation degrees, making...
Abstract Fluorophores lay the material basis for tissue labeling and fluorescence imaging, especially deep‐brain multiphoton microscopy (MPM) in animal models. Among various fluorescent materials, those with aggregation‐induced emission (AIE) characteristics, i.e., AIEgens, have excellent optical properties biocompatibility thus found widespread applications biomedical imaging. However, their application to MPM has so far been limited imaging depth, which undoubtedly poses a hindrance...
Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near-infrared (NIR-II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation-induced emission (AIE)...
Visualization of photothermal therapy mediated by transduction agents (PTAs) is important to promote individual treatment patients with low side effects. Photoacoustic detection has emerged as a promising noninvasive method for the visualization PTAs distribution but still limitations in temperature measurement, including poor measurement accuracy and tissue penetration depth. In this study, we developed biocompatible semiconducting polymer dots (SPD) situ coupling photoacoustic...
Abstract Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near‐infrared (NIR‐II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation‐induced emission...
Abstract Visualization of photothermal therapy mediated by transduction agents (PTAs) is important to promote individual treatment patients with low side effect. Photoacoustic detection has emerged as a promising noninvasive method for the visualization PTAs distribution, but still limitations in temperature measurement, including poor measurement accuracy and tissue penetration depth. In this study, we have developed biocompatible semiconducting polymer dots (SPD) situ coupling...
The core expansion of naphthalene diimides (NDIs) is an effective strategy to modulate frontier molecular orbital energy levels and improve device performances. Herein two new rhodanine-bridged core-extended NDIs T1 T2 were designed synthesized. rhodanine moiety could act not only as a π-spacer enlarge the conjugated system, but also electron-donating unit tune levels. As result, both showed slightly lower lying LUMO (< − 4.2 eV) by ca. 0.1 eV narrower optical band gaps (ca. 1.5 0.5...
<p indent="0mm">Two isomeric 4-methylthiophenylethynyl-substituted 1,4,5,8-naphthalene diimide (1,4,5,8-NDI) and 1,2,5,6-naphthalene (1,2,5,6-NDI) derivatives <bold>1</bold> <bold>2</bold> were designed synthesized. The physicochemical properties of and<bold> 2</bold> studied by means ultraviolet-visible (UV-vis) spectra, electrochemical measurements density functional theory (DFT) calculations. structural differences between led to their different single-molecule device performance....